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Genome Information for Candida albicans
We explored the global transcription profile in response to MMS in C. albicans through RNAseq assay. Here, we identified 407 genes (log2 fold cut off 1.0, P<0.05) whose levels of transcription were significantly affected under the MMS treatment condition; 207 genes were upregulated, and 200 genes were down-regulated. GO term analysis revealed that a small portion of changed genes showed direct roles in DNA repair progress, but a large number of induced genes are involved in antioxidant responses, and some down-regulated genes are involved in nucleosome packing and nitrogen utilization. In addition, the changed transcription of some DNA repair genes, as well as antioxidants genes, are blocked by deleting RAD53. Taken together, treatment of the DNA damage agent MMS induces a global transcriptional change in C. albicans, but not only DNA damage response genes.
Overall design: We used 0.015% MMS to treat the Candida albicans cells and explored the global transcription profile in response to MMS in C. albicans through RNAseq assay.
| Accession | PRJNA804021; GEO: GSE196244 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Candida albicans[Taxonomy ID: 5476] Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade; Candida; Candida albicans |
| Submission | Registration date: 7-Feb-2022
Nantong University |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
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| Sequence data |
| SRA Experiments | 4 |
| Other datasets |
| BioSample | 4 |
| GEO DataSets | 1 |