See
Genome Information for Homo sapiens
Here we performed single-cell RNA sequencing of more than 30,000 of cells from HPV16+ and HPV- cervical cancer patients. We comprehensively revealed the heterogeneity of both the malignant cell populations and immune lineages in HPV+ and HPV- CC, as well as the cellular crosstalks with potential relevance to tumor progression. Moreover, our results demonstrated that distinct interaction patterns in HPV+ and HPV- groups could mediate similar functions or pathways, and we further constructed a three-cell interaction resource.
Overall design: Four fresh samples were obtained from patients with cervical cancer who underwent concurrent chemoradiotherapy
>>> Submitter declares that the raw data have not been submitted due to patient privacy concerns. <<<
| Accession | PRJNA721342; GEO: GSE171894 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Publications | Lin Z et al., "Decoding the tumor microenvironment and molecular mechanism: unraveling cervical cancer subpopulations and prognostic signatures through scRNA-Seq and bulk RNA-seq analyses.", Front Immunol, 2024;15:1351287 |
| Submission | Registration date: 12-Apr-2021
Harbin Medical University |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
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| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| BioSample | 4 |
| GEO DataSets | 1 |