Resistance to PD1 blockade in the absence of metal... (ID 634347) - BioProject

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Accession: PRJNA634347 ID: 634347

Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding (house mouse)

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71183 additional projects are related by organism.

Mechanisms of resistance to cancer immunotherapy remain poorly understood. Lymphocyte Activation Gene-3 (LAG3) signaling is regulated by A Disintegrin And Metalloprotease-10 (ADAM10) and ADAM17-mediated cell surface shedding. More...

Accession	PRJNA634347; GEO: GSE150991
Data Type	Transcriptome or Gene expression
Scope	Multiisolate
Organism	Mus musculus[Taxonomy ID: 10090] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
Publications	Andrews LP et al., "Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding.", Sci Immunol, 2020 Jul 17;5(49)
Grants	"Lymph node-targeted molecular vaccines" (Grant ID R01 EB022433, National Institute of Biomedical Imaging and Bioengineering) "Synergies among inhibitory receptors in tolerance, cancer & antiviral immunity" (Grant ID P01 AI108545, National Institute of Allergy and Infectious Diseases Extramural Activities) "Structure, Function and Mechanistic Analysis of LAG3" (Grant ID R01 AI144422, National Institute of Allergy and Infectious Diseases Extramural Activities)
Submission	Registration date: 21-May-2020 Vignali Lab, Immunology, University of Pittsburgh
Relevance	Model Organism

Project Data:

Resource Name	Number of Links
Sequence data
SRA Experiments	4
Publications
PubMed	1
PMC	1
Other datasets
BioSample	4
GEO DataSets	1

GEO Data Details

Parameter	Value
Data volume, Supplementary Mbytes	49

SRA Data Details

Parameter	Value
Data volume, Gbases	140
Data volume, Mbytes	66400

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Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding (house mouse)

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