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2 additional projects are components of the Genetic models reveal cis and trans immune-regulatory activities for lincRNA-Cox2 in vivo.
Here we compare gene expression profiles between lungs and spleens following LPS in vivo injection into Wild type, lincRNA-Cox2 knockout and lincRNA-Cox2 mutant mice
The aim of the experiment is to determine the cis and trans functions for lincRNA-Cox2 following in vivo LPS challenge within the spleen and lung
Overall design: Lungs and spleens were extracted from 8 week old wild type, lincRNA-Cox2 knockout and mutant mice following 6h of LPS treatment (20mg/kg) and placed directly in Trizol. RNA was isolated and sequenced
| Accession | PRJNA478239; GEO: GSE116354 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Mus musculus[Taxonomy ID: 10090] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus |
| Publications | - Robinson EK et al., "lincRNA-Cox2 Functions to Regulate Inflammation in Alveolar Macrophages during Acute Lung Injury.", J Immunol, 2022 Apr 15;208(8):1886-1900
- Elling R et al., "Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2.", Cell Rep, 2018 Nov 6;25(6):1511-1524.e6
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| Submission | Registration date: 27-Jun-2018
Carpenter Lab, Molecular Cell and Developmental Biology, University of California Santa Cruz |
| Relevance | Model Organism |
Project Data:
| Resource Name | Number
of Links |
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| Sequence data |
| SRA Experiments | 30 |
| Publications |
| PubMed | 2 |
| PMC | 2 |
| Other datasets |
| BioSample | 30 |
| GEO DataSets | 1 |