To identify transcriptional networks that might underlie the accumulation of transitional cells in the absence of mitochondrial complex I function, we performed bulk RNA-sequencing of lung epithelial cells isolated from conditional Ndufs2 knockout mice that express yeast NADH dehydrogenase (NDI1), as well as from conditional Ndufs2 knockout mice without NDI1 expression and from control mice, at P35.
| Accession | PRJNA940730 |
| Data Type | Raw sequence reads |
| Scope | Multispecies |
| Publications | Han S et al., "Mitochondrial integrated stress response controls lung epithelial cell fate.", Nature, 2023 Aug;620(7975):890-897 |
| Grants | - "Modulating mitochondrial function to promote proteostasis in the aging lung" (Grant ID P01 AG049665, National Institute on Aging)
- "Mitochondrial metabolic regulation of lung epithelium: alveolar generation and regeneration" (Grant ID K08 HL143138, National Heart, Lung, and Blood Institute)
- "Single-Cell Transcriptomic Analysis to Identify Drivers of Pulmonary Fibrosis" (Grant ID K08 HL146943, National Heart, Lung, and Blood Institute)
- "Metabolic Regulation of Acute Lung Injury" (Grant ID P01 HL071643, National Heart, Lung, and Blood Institute)
- "Wnt-beta-catenin cross interactions in alveolar macrophages and epithelial cells in persistence of SSc-ILD" (Grant ID R01 HL134800, National Heart, Lung, and Blood Institute)
- "Mitochondrial metabolism and ROS regulate cancer" (Grant ID R35 CA197532, National Cancer Institute)
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| Submission | Registration date: 3-Mar-2023
Dongguk University |
| Relevance | Model Organism |
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| SRA Experiments | 30 |
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| BioSample | 30 |