Deep mutational scanning of alpha-synuclein was performed to identify sequence and structural determinants of its activity, specifically yeast toxicity. DNA sequencing allows use of barcoding to expedite library screening.
| Accession | PRJNA564806 |
| Data Type | Raw sequence reads |
| Scope | Multispecies |
| Grants | - "Project 3: Assembly and structures of Abeta peptides." (Grant ID P01 AG002132, National Institute on Aging)
- "Rewiring of the human protein homeostasis network in normal and disease contexts" (Grant ID DP2 GM119139, National Institute of General Medical Sciences)
- "Deciphering the relationship between structure, dynamics and function in helical bundle proteins" (Grant ID R35 GM122603, National Institute of General Medical Sciences)
- "Molecular and Cellular Basis of Cardiovascular Disease" (Grant ID T32 HL007731, National Heart, Lung, and Blood Institute)
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| Submission | Registration date: 10-Sep-2019
University of California, San Francisco |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| SRA Experiments | 23 |
| Other datasets |
| BioSample | 1 |