This Malaria Host-Pathogen Interaction Center (MaHPIC) is a transdisciplinary malaria systems biology research program initially supported by an NIH/NIAID contract (# HHSN272201200031C, 2012-2017; see http://www.systemsbiology.emory.edu). The MaHPIC has continued with support from the Defense Advanced Research Project Agency (DARPA) and others. The MaHPIC generates many data types (e.g., clinical, hematological, parasitological, metabolomics, functional genomics, lipidomics, proteomics, immune response, telemetry) and mathematical models, to iteratively test and develop hypotheses related to the complex host-parasite dynamics in the course of malaria in non-human primates (NHPs), and metabolomics data via collaborations with investigators conducting clinical studies in malaria endemic countries, with the overarching goal of better understanding human disease, pathogenesis, and immunity. Curation and maintenance of all data and metadata are the responsibility of the MaHPIC.
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| Nucleotide (total) | 45 |
| WGS master | 1 |
| Genomic DNA | 16 |
| SRA Experiments | 618 |
| Protein Sequences | 10733 |
| Publications |
| PubMed | 3 |
| PMC | 3 |
| Other datasets |
| BioSample | 604 |
| GEO DataSets | 14 |
| Assembly | 2 |
This project encompasses the following 18 sub-projects:
| Project Type | Number of Projects |
Genome sequencingHighest level of assembly : Chromosomes Scaffolds SRA or Trace Total |
1
1
2
4
|
BioProject
accession | Assembly
level | Name | Title |
|---|
| PRJNA907388 | SRA or Trace | 16s rRNA samples from the gut microbiome of rhesus macaques | 16s rRNA samples from the gut microbiome of rhesus macaques (Malaria Host-Pathogen Interaction...) | | PRJNA315987 | Chromosomes | An Integrated Approach to Understanding Host-Pathogen Interactions | An Integrated Approach to Understanding Host-Pathogen Interactions (Malaria Host-Pathogen Interaction...) | | PRJNA907397 | SRA or Trace | Metagenomic samples from the gut microbiome of rhesus macaques | Metagenomic samples from the gut microbiome of rhesus macaques (Malaria Host-Pathogen Interaction...) | | PRJNA377737 | Scaffolds | Plasmodium knowlesi | Plasmodium knowlesi Pk1 (A+) Malayan H strain Genome Sequencing, Assembly, and Annotation (Malaria Host Pathogen Interaction...) |
|
| transcriptome | 14 |
BioProject
accession | Organism | Title |
|---|
| PRJNA385819 | Macaca mulatta | Malaria Host Pathogen Interaction Center Experiment 04: Host and parasite gene transcript abundances, from bone marrow aspirate, of Macaca mulatta infected Plasmodium cynomolgi treated with artemether over 7 time points in a 100 day study (GSE94273) (University of Georgia) | | PRJNA385820 | Macaca mulatta | An Integrated Approach to Understanding Host-Pathogen Interactions (SuperSeries GSE94274) (University of Georgia) | | PRJNA385821 | Macaca mulatta | Malaria Host Pathogen Interaction Center: Gene and exon transcript abundances of uninfected Macaca mulatta treated with pyrimethamine over 7 time points in a 100 day study (GSE58340) (University of Georgia) | | PRJNA388645 | Macaca mulatta | Malaria Host Pathogen Interaction Center Experiment 04: Host and parasite gene transcript abundances, from whole blood, of Macaca mulatta infected Plasmodium cynomolgi treated with artemether over 7 time points in a 100 day study (GSE99486) (Emory University) | | PRJNA400137 | Macaca mulatta | Malaria Host Pathogen Interaction Center Experiment 03: Host and parasite gene transcript abundance measures from bone marrow for Macaca mulatta infected with Plasmodium coatneyi Hackeri strain from 7 time points over a 101 day study (GSE103042) (Emory University) |
List all 14 'transcriptome' projects...BioProject
accession | Organism | Title |
|---|
| PRJNA385819 | Macaca mulatta | Malaria Host Pathogen Interaction Center Experiment 04: Host and parasite gene transcript abundances, from bone marrow aspirate, of Macaca mulatta infected Plasmodium cynomolgi treated with artemether over 7 time points in a 100 day study (GSE94273) (University of Georgia) | | PRJNA385820 | Macaca mulatta | An Integrated Approach to Understanding Host-Pathogen Interactions (SuperSeries GSE94274) (University of Georgia) | | PRJNA385821 | Macaca mulatta | Malaria Host Pathogen Interaction Center: Gene and exon transcript abundances of uninfected Macaca mulatta treated with pyrimethamine over 7 time points in a 100 day study (GSE58340) (University of Georgia) | | PRJNA388645 | Macaca mulatta | Malaria Host Pathogen Interaction Center Experiment 04: Host and parasite gene transcript abundances, from whole blood, of Macaca mulatta infected Plasmodium cynomolgi treated with artemether over 7 time points in a 100 day study (GSE99486) (Emory University) | | PRJNA400137 | Macaca mulatta | Malaria Host Pathogen Interaction Center Experiment 03: Host and parasite gene transcript abundance measures from bone marrow for Macaca mulatta infected with Plasmodium coatneyi Hackeri strain from 7 time points over a 101 day study (GSE103042) (Emory University) | | PRJNA400695 | Macaca mulatta | Malaria Host Pathogen Interaction Center Experiment 03: Host and parasite gene transcript abundance measures from whole blood for Macaca mulatta infected with Plasmodium coatneyi Hackeri strain from 7 time points over a 101 day study (GSE103259) (Emory University) | | PRJNA401436 | Macaca mulatta | Malaria Host Pathogen Interaction Center Experiment 04R: Host and parasite gene transcript abundances, from whole blood, of Macaca mulatta infected Plasmodium cynomolgi treated with artemether over 7 time points in a 100 day study (GSE103507) (Emory University) | | PRJNA408250 | Macaca mulatta | Malaria Host Pathogen Interaction Center Experiment 24: Host and parasite gene transcript abundances, from whole blood, of Macaca mulatta infected Plasmodium cynomolgi B strain treated with artemether over 3 time points in a 46 day study (GSE104101) (Emory University) | | PRJNA412080 | Macaca mulatta | Malaria Host Pathogen Interaction Center Experiment 23R: Host and parasite gene transcript abundances, from whole blood, of Macaca mulatta infected Plasmodium cynomolgi B strain treated with artemether over 7 time points in a 100 day study (GSE104223) (University of Georgia) | | PRJNA412382 | Macaca mulatta | Malaria Host Pathogen Interaction Center Experiment 25: Host and parasite gene transcript abundances, from whole blood, of Macaca mulatta infected Plasmodium cynomolgi strain ceylonensis treated with artemether over 5 time points in a 61 day study (GSE104330) (Emory University) | | PRJNA435509 | Macaca mulatta | Malaria Host Pathogen Interaction Center Experiment S01: Host and parasite gene transcript abundances, from cultured cells, of Macaca mulatta infected with Plasmodium knowlesi Pk1(A+), Pk1(B )1 , Pk1(C ) ex vivo time course (GSE110970) (Emory University) | | PRJNA508940 | Macaca mulatta | Malaria Host Pathogen Interaction Center Experiment 30 - Pilot experiment for Macaca mulatta infected with Plasmodium knowlesi Malayan strain sporozoites to produce and integrate measures of acute primary infection. (GSE123495) (Emory University) | | PRJNA524357 | Macaca mulatta | Malaria Host Pathogen Center Experiment 06: Macaca mulatta infected with Plasmodium knowlesi sporozoites to produce and integrate clinical, hematological, parasitological, omics, telemetric, and histopathological measures of acute primary infection. (GSE127079) (University of Georgia) | | PRJNA526495 | Macaca mulatta | Malaria Host Pathogen Center Experiment 07A and 07B - Macaca fascicularis infected with Plasmodium knowlesi to produce and integrate clinical, hematological, parasitological, omics, telemetric and histopathological measures of acute primary infection. (GSE128115) (University of Georgia) |
Less... |