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Organizing biological data
Effect of Col1a2 mutation in the gene expression of immature and mature osteoblasts in a mouse model of osteognesis imperfecta (OI)
Single-cell RNA sequencing analysis of the effect of 4-octyl itaconate administration on gene expression in immune cells isolated from traumatic brain injury mice brain
Genetic Landscape and Phenotypic Spectrum of Osteogenesis Imperfecta in the Kazakhstani Pediatric Population
The IFITM5 mutation in osteogenesis imperfecta type V is associated with an ERK/SOX9-dependent osteoprogenitor differentiation defect
Effect of 4-octyl itaconate on gene expression of dendritic cells
Multi-Omic analyses reveal aberrant differentiation trajectory with WNT1 Loss-of-Function in type XV osteogenesis imperfecta
Trancsriptomic analyses reveal aberrant differentiation trajectory with WNT1 Loss-of-Function in type XV osteogenesis imperfecta
Mus musculus
Itaconate alleviates anesthesia/surgery-induced cognitive impairment by activating a Nrf2-dependent anti-neuroinflammation and neurogenesis via gut-brain axis
Fgf9 promotes adipogenesis and reduces osteogenesis by regulating mesenchymal stromal cells differentiation in adult bone marrow
OSTEOGENESIS IMPERFECTA
In this study, our objective is to broaden the understanding of the genetic and clinical characteristics of OI by investigating rare pathogenic variants (PVs) not only within the well-established COL1A1 and COL1A2, which are responsible for more than 85-90% of all cases but also in other genes involved in OI. To achieve this, we performed next-generation sequencing (NGS) analysis on OI patients from the Puglia Region in South Italy, a population with limited genetic data on OI
OSTEOGENSIS IMPERFECTA
NGS DATA for OSTEOGENESIS IMPERFECTA affected patients
Expanding the Genetic and Clinical Spectrum of Osteogenesis Imperfecta: Identification of Novel Rare Pathogenic Variants in Type I Collagen-Encoding Genes
Acod1-mediated effect on osteoclast differentiation
Itaconate enhances oncolytic virotherapy via multitarget inhibition of antiviral and inflammatory pathways
Single-cell RNA-sequencing of the mouse Dorsomedial Hypothalamic Nucleus (DMH)
Altered cartilage gene expression in Aga2 OI mouse negatively impacts linear growth through Sox9 and FGF signaling
Effect of Irg1-Itaconate on Nrf2-transcripting genes in macrophages by using chromatin immunoprecipitation-sequencing (ChIP-seq) assays.
Effects of Irg1-itaconate or Hemin on gene expression in macrophages [RNA-seq]
Effect of Sclerostin Inactivation in a Mouse Model of Severe Dominant Osteogenesis Imperfecta
RNA-seq Transcriptomic Analysis of 4-octyl itaconate Repressing Myogenic Differentiation
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