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Organizing biological data
Mast cell heterogeneity in human nasal polyps
Viral triggers of Type 1 diabetes: Effects of Coxsackie B virus infection on transcriptome of trophoblast and pancreatic beta cell lines.
IL-12 drives the expression of the inhibitory receptor NKG2A on human tumor-reactive CD8 T cells
High-fidelity PAMless base editing of hematopoietic stem cells to treat chronic granulomatous disease
Illumina MiSeq analysis validated the appropriateness of leaf-based culture media as an in situ similis culturomic strategy of plant microbiota
Human herpesvirus-6B infection and alterations of gut microbiome in patients with fibromyalgia: a pilot study
Fibromyalgia and gut microbiome
Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells
Transcriptomic profiling of LLC LeptoM vector control, Nr1h2/3 DKO and RXRa/b/g TKO upon stimulation with 1μM 9 cis-retinoic acid (RA) in vitro
Adipose-derived mesenchymal stem cells overexpressing thrombomodulin reduce thrombogenic risk and enhance therapeutic efficacy
Hepatocyte identity and zonal position determine tumourigenic potential of mutant β-catenin
Mus musculus
Smad7-based biologic targeting epidermis and stroma promotes healing of diabetic wounds in mice and pigs
GBS manuscript
Molecular characterization of Group B strep in South Africa
Restricted sugar and ketogenic diets can both alter energy balance and metabolism, but any resultant decrease in energy intake may be counteracted by compensatory reductions in energy expenditure. In healthy adults, randomization to restriction of free-sugars or overall carbohydrates (ketogenic diet) for 12 weeks reduced fat mass without changes in physical activity or resting metabolic rate, compared to a control diet. Free-sugar restriction had minimal effect on metabolism or gut microbiome other than decreased serum low-density lipoprotein cholesterol concentrations. In contrast, ketogenic diet-induced weight loss decreased glucose tolerance, coinciding with increased PDK4 and reduced AMPK and GLUT4 levels in skeletal muscle. In the first 4 weeks, the ketogenic diet reduced fasting glucose, increased apolipoprotein B, C-reactive protein and postprandial glycerol concentrations. However, despite sustained ketosis, these effects were no longer apparent by week 12, when gut microbial beta diversity was altered, possibly reflective of longer-term ketotic adaptation and/or new energy balance status. These data demonstrate that restricting either free-sugars or overall carbohydrates can reduce energy intake without altering physical activity, but with divergent effects on glucose tolerance, lipoprotein profiles and gut microbial composition.
Ketogenic diet (but not sugar restriction) alters glucose tolerance, lipid metabolism, peripheral tissue phenotype and the gut microbiome: an RCT.
Sequences within and upstream of the mouse Ets1 gene drive high level expression in B cells, but are not sufficient for consistent expression in T cells
Preventive Treatment with a CD73 Small Molecule Inhibitor Enhances Immune Surveillance in K-Ras Mutant Pancreatic Intraepithelial Neoplasia
Dual Role of Neuroplastin in Pancreatic β Cells: Regulating Insulin Secretion and Promoting Islet Inflammation
12-Lipoxygenase Inhibition Suppresses Islet Immune and Inflammatory Responses and Delays Autoimmune Diabetes in Human Gene Replacement Mice.
12-Lipoxygenase Inhibition Suppresses Islet Immune and Inflammatory Responses and Delays Autoimmune Diabetes in Human Gene Replacement Mice
IFN-ɣ derived from activated human CD4+ T cells inhibits the replication of SARS-CoV-2 depending on cell-type and viral strains.
WGBS of medial frontal cortices of P28 offspring from breeding of Dnmt3l conditional knockin and Emx1-cre mice
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