BioProject

We report here, as part as of our ongoing research, the synthesis, and the solution spectra (FT-IR, 1H-NMR, GC-Mass) of the C2-5-bromosalicylaldehyde-C6-aniline double schiff bases derivative of chitosan was synthesized from the condensation reaction of equimolar amounts of 5-bromosalicylaldehyde, chitosan and aniline in DMSO. More...

We report here, as part as of our ongoing research, the synthesis, and the solution spectra (FT-IR, 1H-NMR, GC-Mass) of the C2-5-bromosalicylaldehyde-C6-aniline double schiff bases derivative of chitosan was synthesized from the condensation reaction of equimolar amounts of 5-bromosalicylaldehyde, chitosan and aniline in DMSO. The chitin and the phenyl rings deviate from co-planarity with an inter and intra-molecular (–C2-N=CH–) and bond (–C6–C=N–). The title compound C69H118BrN10O41 is not planner, with dihedral angle between the planes of the three aryl rings. From the FT-IR testing of 5BSCA biomaterial there are CH=N, C=N, broad of OH, NH groups were the absorption peak occurs in the area 1650.02 cm-1 , 3009.96 cm-1, 3938.60 cm-1 and 3441.33 cm-1. The 1H-NMR peak of the schiff base ligand displayed the phenolic OH singlet at 10.137 ppm of -C=N- proton of aniline and chitosan, the signal due to 5-bromosalicylaldehyde at 9.917 ppm is shifted to azomethane (-CH=N-) proton resonated at 8.87 ppm. From TG-DSC curve the thermal stability of the new compound was calculated as164.9°C. The Schiff base ligand of the GC-Mass spectrum presented a molecular ion peak recorded at m/z 1821 g/mol which is corresponding to its molecular weight. The structure is heterocyclic derivative constituting a stimulating class of compound with synthetic flexibility and effective biological activities. The derivatives have remarkable pharmacological activities like anti-bacterial, anti-fungal, anti-oxidant, anti-cancer, anti-inflammatory compound. Less...