BioProject

Objective: Evaluate performance of antigen detection rapid diagnostic test (Ag-RDT) for detection of SARS-CoV-2 in relation to onset of infection for symptomatic and asymptomatic participants. More...

Objective: Evaluate performance of antigen detection rapid diagnostic test (Ag-RDT) for detection of SARS-CoV-2 in relation to onset of infection for symptomatic and asymptomatic participants.

Design, Setting, and Participants: Prospective cohort study conducted from October 2021 to February 2022 among participants > 2 years-old from across the US who enrolled using a smartphone app. During each testing encounter, participants self-collected one nasal swab and performed Ag-RDT at home; at-least fifteen minutes later, a second nasal swab was self-collected and shipped for SARS-CoV-2 RT-PCR at a central lab. Both nasal swabs were collected 7 times at 48-hour intervals (over approximately 14 days) followed by an extra nasal swab collection with home Ag-RDT test 48-hours after their last PCR sample. Each participant was assigned to one of the three emergency use authorized (EUA) Ag-RDT tests used in this study. This analysis was limited to participants who were asymptomatic and tested negative by antigen and molecular test on their first day of study participation. Less...