BioProject

The ultimate goal of this proposal is to develop a novel platform technology for automatic surveillance and tracing of airborne SARS-CoV-2 virus particles in real time. More...

The ultimate goal of this proposal is to develop a novel platform technology for automatic surveillance and tracing of airborne SARS-CoV-2 virus particles in real time. The centerpiece of this proposal is the "Rolosense" technology, which leverages a DNA micromotor as the virus sensing and transduction material (VSTM) that can be detected by a conventional smart phone camera. This provides both geographical tracing and surveillance. Rolosense motors are comprised by a DNA-coated spherical particle (5 micrometers diameter) that hybridizes to a surface bound with complementary RNA. The particle moves at speeds of over 1 micron/minute upon the addition of RNase H, which selectively hydrolyses hybridized RNA but not single-stranded RNA. DNA motors coated with virus binding ligand (VBL)... (for more see dbGaP study page.) Less...