BioProject

COVID-19, a global pandemic due to its rapid progression, is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). More...

COVID-19, a global pandemic due to its rapid progression, is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There are different assays for COVID-19, including nucleic acid, serological, antigen, and ancillary tests used in hospitals. In this study we will develop a biochip assay that can simultaneously detect SARS-CoV-2 protein and RNA from biofluids by using surface markers, while simultaneously detecting/quantifying target proteins and RNA at single virus resolution. Amplification of the signals will be achieved by targeting different regions of the viral RNA (e.g., viral nucleocapsid N1, N2), and a tyramide signal amplification (TSA) assay for viral surface proteins. To demonstrate the clinical utility of the technology, it will be tested with different... (for more see dbGaP study page.) Less...