BioProject

In this study, it was found that in the midgut of adult Drosophila, the chloride channel ClC-c ClC-c was only expressed in stem /progenitor cells, and inhibition of ClC-c in Drosophila midgut ISCs leads to stem cell loss and inhibitions of stem cell proliferation. More...

In this study, it was found that in the midgut of adult Drosophila, the chloride channel ClC-c ClC-c was only expressed in stem /progenitor cells, and inhibition of ClC-c in Drosophila midgut ISCs leads to stem cell loss and inhibitions of stem cell proliferation. To investigate the mechanism with which ClC-c regulates the proliferation of ISCs in Drosophila melanogaster, RNA-seq was performed on dissected midguts with ClC-c depleted in esg+ cells (esgts> ClC-c RNAi) and control (esgts> WT) midguts carrying just esgts-Gal4. A number of genes that have been reported to regulate intestinal stem or progenitor cell proliferation in Drosophila were significantly down-regulated in midguts with ClC-c depleted in esg+ cells. Less...