We show that base editing can rescue the function and survival of cone photoreceptors in a mouse model of inherited retinal degeneration, which has been a major challenge in the treatment of inherited blindness.
| Accession | PRJNA739996 |
| Data Type | Raw sequence reads |
| Scope | Multispecies |
| Grants | - "Medical Scientist Training Program" (Grant ID T32 GM007250, National Institute of General Medical Sciences)
- "Pre-doctoral Training Program in Molecular Therapeutics" (Grant ID T32 GM008803, National Institute of General Medical Sciences)
- "CRISPR/Cas9-Mediated Correction of Abca4 Mutations in a Stargardt Mouse Model" (Grant ID F30 EY029136, National Eye Institute)
- "Retinoids in Vision" (Grant ID R01 EY009339, National Eye Institute)
- "Use of systems pharmacology to prevent rod and cone photoreceptor degeneration" (Grant ID R24 EY027283, National Eye Institute)
- "Cole Eye Institute Vision Science Training Program" (Grant ID T32 EY024236, National Eye Institute)
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| Submission | Registration date: 22-Jun-2021
University of California, Irvine |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| SRA Experiments | 33 |
| Other datasets |
| BioSample | 4 |