See
Genome Information for Homo sapiens
We report that knock out of all mAtg8s (HexaKO) reduced the differential gene expression 451 and upregulated the expression of 294 genes, in addition of several previous known TFEB targets
Overall design: We comapred the differential gene expression in in HeLa wild type and HeLa cells depleted for ATG3, GABARAPs ( GABARAP GABARAPL1 and GABARAPL2) and all six mAtg8s (LC3A, LC3B,LC3C, GABARAP, GABARAPL1, GABARAPL2)
| Accession | PRJNA628988; GEO: GSE149533 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Publications | Kumar S et al., "Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens.", Nat Cell Biol, 2020 Aug;22(8):973-985 |
| Grants | - "Autophagy, Inflammation and Metabolism (AIM) in Disease Center" (Grant ID P20 GM121176, National Institute of General Medical Sciences)
- "Autophagy Against Tuberculosis and HIV" (Grant ID R01 AI111935, National Institute of Allergy and Infectious Diseases Extramural Activities)
- "Pattern Recognition Receptors and Autophagy in Mtb Control in AIDS" (Grant ID R37 AI042999, National Institute of Allergy and Infectious Diseases Extramural Activities)
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| Submission | Registration date: 28-Apr-2020
MGM, University of new Mexico l |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
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| Sequence data |
| SRA Experiments | 6 |
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| BioSample | 6 |
| GEO DataSets | 1 |