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Genome Information for Francisella tularensis
Francisella tularensis subsp. tularensis strain Schu S4. This subspecies is virulent in humans, and the strain is a clinical isolate that is also virulent in an animal model. More...
Francisella tularensis subsp. tularensis strain Schu S4. This subspecies is virulent in humans, and the strain is a clinical isolate that is also virulent in an animal model. Originally isolated from a human case of tularemia in 1951. Genome analysis indicates the presence of a large number of pseudogenes, many that disrupt important metabolic pathways, which is the reason for the exacting nutritional requirements of this organism. There is a duplicated pathogenicity island that has also been detected in strain LVS and mutations in the iglA, iglC, or pdpD genes affect the ability of the pathogen to survive in macrophages. The genome also contains genes for type IV pili production and capsular polysaccharide genes similar to those of Bacillus anthracis as well as numerous ABC transporters. There are a large number of insertion sequences including a mariner element, which is a transposon typically found in eukaryotes and is the first instance of this element to be found in a microbe, which may have acquired it during transit through one of the insect vectors.
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Accession | PRJNA57589 |
Data Type | RefSeq Genome |
Scope | Monoisolate |
Organism | Francisella tularensis subsp. tularensis SCHU S4[Taxonomy ID: 177416] Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales; Francisellaceae; Francisella; Francisella tularensis; Francisella tularensis subsp. tularensis SCHU S4 |
Publications | Prior RG et al., "Preliminary analysis and annotation of the partial genome sequence of Francisella tularensis strain Schu 4.", J Appl Microbiol, 2001 Oct;91(4):614-20 |
Submission | Registration date: 21-Oct-2010
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Project Data:
Resource Name | Number of Links |
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Publications |
PubMed | 1 |
No public data is linked to this project. Any recently released data that cites this project will be linked to it within a few days.
Related GenBank Project
PRJNA9 : Aquatic bacterium that cause tularemia