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Accession: PRJNA534038 ID: 534038

Delineating the molecular pathways regulated by IFN-gamma and IL-17 in the small intestines of humanized mice during staphylococcal superantigen-induced toxic shock syndrome (house mouse)

See Genome Information for Mus musculus
RNASeq identified several pathways that were differentially expressed/regulated in the small intestines that correlated with intestinal failure during toxic shock syndrome caused by staphylococcal superantigen in a humanized mouse model Overall design: To study the changes in gene expression in the small intestines during staphylococcal superantigen-induced toxic shock syndrome by RNA-Seq
AccessionPRJNA534038; GEO: GSE130125
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
PublicationsKale SD et al., ""Small" Intestinal Immunopathology Plays a "Big" Role in Lethal Cytokine Release Syndrome, and Its Modulation by Interferon-γ, IL-17A, and a Janus Kinase Inhibitor.", Front Immunol, 2020;11:1311
SubmissionRegistration date: 22-Apr-2019
Biocomplexity Institute, Virginia Tech
RelevanceModel Organism
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments21
Publications
PubMed1
PMC1
Other datasets
BioSample21
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes8
SRA Data Details
ParameterValue
Data volume, Gbases107
Data volume, Mbytes41609

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  • Delineating the molecular pathways regulated by IFN-gamma and IL-17 in the small...
    Delineating the molecular pathways regulated by IFN-gamma and IL-17 in the small intestines of humanized mice during staphylococcal superantigen-induced toxic shock syndrome
    Delineating the molecular pathways regulated by IFN-gamma and IL-17 in the small intestines of humanized mice during staphylococcal superantigen-induced toxic shock syndrome
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