BioProject

Marine sponges are prolific sources of unique bioactive natural products. The sponge Theonella swinhoei is represented by several distinct variants with largely non-overlapping chemistry. More...

Marine sponges are prolific sources of unique bioactive natural products. The sponge Theonella swinhoei is represented by several distinct variants with largely non-overlapping chemistry. For the Japanese chemotype Y harboring diverse complex polyketides and peptides, we previously provided genomic and functional evidence that a single symbiont, the filamentous, multicellular organism ‘Candidatus Entotheonella factor’, produces almost all of these compounds. To obtain further insights into the chemistry of ‘Entotheonella’, we investigated another phylotype, ‘Candidatus Entotheonella serta’, present in the T. swinhoei WA sponge chemotype, a source of theonellamide- and misakinolide-type compounds. The data suggest that both compound families, which were among the earliest model substances to study bacterial producers in sponges, originate from the same bacterium in T. swinhoei WA. They also add evidence that metabolic richness and variability could be a more general feature of ‘Entotheonella’ symbionts.

Note that this upload does not precisely match the statistics presented in Table S1 of the attached paper due to NCBI's minimum contig length. Less...