BioProject

γδ T cells are highly conserved in all vertebrates, suggesting an important benefit. More...

γδ T cells are highly conserved in all vertebrates, suggesting an important benefit. However, γδ T cell-deficient Tcrd–/– mice display a surprisingly mild phenotype. To investigate the function of IL-17 producing γδ T cells (γδT17 cells) in experimental models for psoriasis and chronic fungal infection, we established and applied diphtheria toxin-mediated conditional γδ T cell-depletion. IFN-γ producing γδ T cell subsets reappeared quickly after depletion, while γδT17 cells recovered inefficiently and their empty homeostatic niches were filled by expanding ILC3s. Direct visualization, parabiosis, and complementary genetic labeling further revealed that γδT17 cells are motile but partially tissue-resident, long-lived and self-renewing lymphocytes. Together, this clarifies that γδT17 cells act as innate local and systemic regulators of IL-17-driven inflammation. Less...