BioProject

The Natronobacterium gregoryi Argonaute (NgAgo)-guide DNA (gDNA) system was reported to have powerful genome editing capacity by Han Chunyu group. More...

The Natronobacterium gregoryi Argonaute (NgAgo)-guide DNA (gDNA) system was reported to have powerful genome editing capacity by Han Chunyu group. However, many related studies have shown no genome editing. For example, recently Liang X. group firstly demonstrated the potential of NgAgo/gDNA in inhibiting HBV replication through accelerating pgRNA degradation, but not DNA editing. Therefore, we grew this archaea and then sequenced the whole genome. The existing submissions are not updated for one year already. We tried to analyse the endogenous oligonucleotides-guide DNA and locate it in the genome. Here we sequenced the whole genome of Natronobacterium gregoryi SP2. Less...