BioProject

The experimental pathophysiology of organophosphorus (OP) chemical exposure has been extensively reported. More...

The experimental pathophysiology of organophosphorus (OP) chemical exposure has been extensively reported. Here, we describe for the first time an altered fecal microbiota and urine metabolome that follows intoxication with soman, a lipophilic G class chemical warfare nerve agent. Non-anaesthetized Sprague-Dawley male rats were subcutaneously administered soman at 0.8 - 1.0 of the median lethal dose (LD50) and evaluated for signs of toxicity. Animals were stratified based on seizing activity to evaluate effects of soman exposure on fecal bacterial biota. Less...