BioProject

PGG is a natural product exhibits anti-cancer effects on different type of cancers including liver cancer cell lines. More...

PGG is a natural product exhibits anti-cancer effects on different type of cancers including liver cancer cell lines. In present study we identified a set of genes affected by PGG treatment in Huh7 cells. Some of them, for example, control cell cycle and cell proliferation. We used microarrays to delineate the mechnism of action of PGG on GNMT expression in HCC. We identified distinct classes of up-regulated and down-regulated genes after PGG treatment in Huh7 cells. Overall design: Huh7 cells were seeded for 24 hours. Cells were then treated with PGG 6 hr, PGG 48 hr and PBS 48 hr. Cells were harvested for RNA extraction and hybridization on Affymetrix Microarray. Differentially expression genes between PGG treatment and PBS control were identified for functional study. Less...