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Accession: PRJNA1168965 ID: 1168965

Effect of inhibiting Neurl1b in repopulating hepatocytes in Fah-/-;dCas9 liver injury and repopulation model (house mouse)

See Genome Information for Mus musculus
To study the mechanism of NEURL1B in regulating hepatocyte mitosis, we profiled the ribosome bounded mRNA of control and Neurl1b-inhibited repopulating hepatocytes by using TRAP-seq (translating ribosome affinity purification followed by high-throughput RNA sequencing) Overall design: To inverstigate the effect of inhibiting Neurl1b on repopulating hepatocytes, we expressed FAH, GFP-L10a fusion protein and sgRNA agasint Neurl1b in Fah-/-;dCas9 hepatocytes, we then profiled ribosome bounding mRNAs by TRAP-seq (translating ribosome affinity purification followed by high-throughput RNA sequencing)
AccessionPRJNA1168965; GEO: GSE278809
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
SubmissionRegistration date: 4-Oct-2024
Mayo Clinic
RelevanceModel Organism
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments6
Other datasets
BioSample6
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes3
SRA Data Details
ParameterValue
Data volume, Gbases17
Data volume, Mbytes6289

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