Human neuroblastoma cell line IMR32 expressing Cas9 was transduced with the Brunello genome-wide gRNA library, followed by co-culturing with primary human lymphocytes +/- nivolumab.
More...Human neuroblastoma cell line IMR32 expressing Cas9 was transduced with the Brunello genome-wide gRNA library, followed by co-culturing with primary human lymphocytes +/- nivolumab. After 6 days, cells were harvested and gRNA frequencies were defined using next-generation sequencing. Depleted gRNAs after nivolumab represent resistance genes to nivolumab.
Less...| Accession | PRJEB79225 |
| Scope | Monoisolate |
| Submission | Registration date: 30-Sep-2024
Uppsala University |
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