Effect of mutant GNAS expression in doxycycline-in... (ID 1150614) - BioProject

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Accession: PRJNA1150614 ID: 1150614

Effect of mutant GNAS expression in doxycycline-inducible murine pancreatic cancer cell lines (house mouse)

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This project is a component of the IPMN model mice with Kras;Gnas mutation

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2 additional projects are components of the IPMN model mice with Kras;Gnas mutation.

71031 additional projects are related by organism.

We investigated the transcriptomic effect of GNAS(R201C) expression in murine cell lines derived from the Kras;Gnas model of pancreatic intraductal papillary mucinous neoplasms where transgenic mutant GNAS is doxycycline inducible (LGKC; p48(Cre), Kras(LSL-G12D), Rosa26(LSL-rtTA)), Tg(TetO-GNAS(R201C)) using bulk RNA-seq. More...

Accession	PRJNA1150614; GEO: GSE275403
Data Type	Transcriptome or Gene expression
Scope	Multiisolate
Organism	Mus musculus[Taxonomy ID: 10090] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
Publications	Makino Y et al., "Metabolic reprogramming by mutant GNAS creates an actionable dependency in intraductal papillary mucinous neoplasms of the pancreas.", Gut, 2024 Sep 25;
Submission	Registration date: 21-Aug-2024 Maitra laboratory, Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
Relevance	Model Organism

Project Data:

Resource Name	Number of Links
Sequence data
SRA Experiments	16
Publications
PubMed	1
Other datasets
BioSample	16
GEO DataSets	1

GEO Data Details

Parameter	Value
Data volume, Supplementary Mbytes	1

SRA Data Details

Parameter	Value
Data volume, Gbases	122
Data volume, Mbytes	42847

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Effect of mutant GNAS expression in doxycycline-inducible murine pancreatic cancer cell lines (house mouse)

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