Effect of overexpressing a dominant negative LXRal... (ID 1140263) - BioProject

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Accession: PRJNA1140263 ID: 1140263

Effect of overexpressing a dominant negative LXRalpha mutant in HepG2 cells (human)

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Dominant negative mutatons in nuclear receptors can repress target gene expression, thus having stronger effects than simple loss of gene function. More...

Accession	PRJNA1140263; GEO: GSE273158
Data Type	Transcriptome or Gene expression
Scope	Multiisolate
Organism	Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
Publications	Lockhart SM et al., "Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health.", Nat Metab, 2024 Oct;6(10):1922-1938
Submission	Registration date: 25-Jul-2024 Metabolic Research Laboratories, University of Cambridge
Relevance	Medical

Project Data:

Resource Name	Number of Links
Sequence data
SRA Experiments	24
Publications
PubMed	1
PMC	1
Other datasets
BioSample	24
GEO DataSets	1

GEO Data Details

Parameter	Value
Data volume, Supplementary Mbytes	8

SRA Data Details

Parameter	Value
Data volume, Gbases	35
Data volume, Mbytes	11354

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Effect of overexpressing a dominant negative LXRalpha mutant in HepG2 cells
Effect of overexpressing a dominant negative LXRalpha mutant in HepG2 cells
Effect of overexpressing a dominant negative LXRalpha mutant in HepG2 cells

BioProject
1-deoxy-D-xylulose-5-phosphate synthase [Micrococcus luteus]
1-deoxy-D-xylulose-5-phosphate synthase [Micrococcus luteus]
gi|1949955430|gnl|PRJNA231221|I6H91 0|gb|QQE49939.1|

Protein
bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophospho...
bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [Micrococcus luteus]
gi|1949955429|gnl|PRJNA231221|I6H91 5|gb|QQE49938.1|

Protein
MAG: hypothetical protein AMJ62_03695 [Myxococcales bacterium SG8_38]
MAG: hypothetical protein AMJ62_03695 [Myxococcales bacterium SG8_38]
gi|931431203|gb|KPK16896.1||gnl|WGS |AMJ62_03695

Protein
MAG: hypothetical protein AMJ62_03850 [Myxococcales bacterium SG8_38]
MAG: hypothetical protein AMJ62_03850 [Myxococcales bacterium SG8_38]
gi|931431193|gb|KPK16886.1||gnl|WGS |AMJ62_03850

Protein

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Effect of overexpressing a dominant negative LXRalpha mutant in HepG2 cells (human)

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