BioProject

This is a prospective longitudinal study that aimed to investigate whether physical training would modify the whole blood methylation profile in healthy women. More...

This is a prospective longitudinal study that aimed to investigate whether physical training would modify the whole blood methylation profile in healthy women. A total of 43 individuals were involved in a physical training protocol during a 7-week follow-up, consisting of cardiorespiratory aerobic and muscular strength exercises. Subjects were after 7 weeks of physical training (POST 7). Primary functional outcomes included anthropometric, blood pressure, biochemical measurements, physical tests, and global health assessments. Blood samples were collected at each time point to determine the methylation profile using a DNA methylation array technique to track up to 850,000 different sites. Exercise training lowered blood pressure and triglyceride levels and improved physical performance, including maximal strength in the upper and lower body. Furthermore, physical training improved quality of life markers. By entering the differentially methylated sites into the pathway analysis, we found several pathways involved in the regulation of whole-body metabolism, including AMPK signaling, TGF-beta signaling, and insulin signaling. This study demonstrates that exercise training promotes a robust change in whole blood methylation profile and provides new insights into key regulators of exercise-induced benefits. Overall design: MethylationBrazil Assay Less...