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Genome Information for Homo sapiens
Recently, single cell RNA sequencing has been used to analyze cell-cell interactions between colon cancer cells and stromal cells.
More...Recently, single cell RNA sequencing has been used to analyze cell-cell interactions between colon cancer cells and stromal cells. However, the important cancer microenvironment during early cancer development from adenomas, especially the mechanism of immune tolerance acquisition, is unclear. In this study, we investigated immune tolerance and the formation of the tumor microenvironment at the adenoma-cancer interface by integrating single-cell and spatial transcriptome analyses obtained from public databases. By integrating scRNA-seq of colorectal cancer and spatial transcriptome analysis in carcinoma in adenoma tissues, we investigated immune tolerance and tumor microenvironment formation at the adenoma-tumor interface, and thereby searching for new therapeutic target molecules.The Data Access Committee of the National Bioscience Database Center (NBDC) approved that this personal data was made published according to the NBDC Guidelines for Human Data Sharing (https://humandbs.biosciencedbc.jp/en/guidelines/data-sharing-guidelines) as the NBDC Research ID hum0356 and the application ID J-DS000637-002.
Less...| Accession | PRJDB16055 |
| Data Type | Genome sequencing |
| Scope | Monoisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Publications | Hashimoto M et al., "Spatial and single-cell colocalisation analysis reveals MDK-mediated immunosuppressive environment with regulatory T cells in colorectal carcinogenesis.", EBioMedicine, 2024 May;103:105102 |
| Grants | - "Clarification of the bona-fide evolution from early to advanced CRC to establish the eradication methods." (Grant ID JPK19H03715, Japan Society for the Promotion of Science)
- "Aberrant Regulation of Protein Translation Start Sites in Colorectal Cancer Identified by Genome Evolution Models" (Grant ID JPK19K09176, Japan Society for the Promotion of Science)
- "Multi-regional analysis and the simulation of evolution elucidate the intra-tumor diversity of colorectal cancer." (Grant ID JPK20H05039, Japan Society for the Promotion of Science)
- "Establishment of early diagnosis of colorectal cancer recurrence by a new approach implementing ctDNA methylation detection" (Grant ID JPK20K08930, Japan Society for the Promotion of Science)
- "Clinical Significance of Evolutionary Phylogenetic Tree for Colorectal Cancer ctDNA for Early Postoperative Recurrence Diagnostic System Development and Recurrence" (Grant ID JPK21K07179, Japan Society for the Promotion of Science)
- "Elucidation of molecular genetic diversity creation mechanism of intractable cancer linked to microenvironmental diversity and development of new cancer therapies and predictive medical technologies" (Grant ID 19cm0106504h0004, Japan Agency for Medical Research and Development)
- "Establishment of novel preventive treatment strategies by understanding the mechanism of colorectal cancer micrometastasis formation" (Grant ID 20ck0106541h0001, Japan Agency for Medical Research and Development)
- "Establishment of a ctDNA detection method targeting intractable cancer-specific epigenomic mutations" (Grant ID 20cm0106475h0001, Japan Agency for Medical Research and Development)
- "Establishment of a ctDNA detection method targeting intractable cancer-specific epigenomic mutations" (Grant ID 22ama221501h0001, Japan Agency for Medical Research and Development)
- "A super sensitive circulating tumor DNA monitoring using individualized digital PCR" (Grant ID 23ck0106825h0001, Japan Agency for Medical Research and Development)
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| Submission | Registration date: 18-Apr-2024
Department of Surgery, Kyushu University Beppu Hospital |
Project Data:
| Resource Name | Number
of Links |
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| Publications |
| PubMed | 1 |
| PMC | 1 |
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