FOXO1 enhances CAR T cell stemness, metabolic fitn... (ID 1096359) - BioProject

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Accession: PRJNA1096359 ID: 1096359

FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy [human_FOXO1OE_stimulation/rest_RNAseq] (human)

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This project is a component of the Overexpression of FOXO1 enhances CAR T cell polyfunctionality, metabolic fitness and efficacy against solid tumors

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6 additional projects are components of the Overexpression of FOXO1 enhances CAR T cell polyfunctionality, metabolic fitness and efficacy against solid tumors.

95218 additional projects are related by organism.

Investigating the transcriptional profile of human FOXO1 overexpressing α-lewisY CAR T cells after stimulation or after stimulation and rest Overall design: Human anti-Lewis Y CAR T cells overexpressing FOXO1 or mCherry (control) were generated from healthy donor peripheral blood mononuclear cells (PBMC). More...

Accession	PRJNA1096359; GEO: GSE263257
Data Type	Transcriptome or Gene expression
Scope	Multiisolate
Organism	Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
Publications	Chan JD et al., "FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy.", Nature, 2024 May;629(8010):201-210
Submission	Registration date: 4-Apr-2024 Beavis Lab, Cancer Immunology, Peter MacCallum Cancer Centre
Relevance	Medical

Project Data:

Resource Name	Number of Links
Sequence data
SRA Experiments	18
Publications
PubMed	1
PMC	1
Other datasets
BioSample	18
GEO DataSets	1

GEO Data Details

Parameter	Value
Data volume, Supplementary Mbytes	3

SRA Data Details

Parameter	Value
Data volume, Gbases	11
Data volume, Mbytes	1341

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FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy [human_FOXO1OE_stimulation/rest_RNAseq] (human)

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