Macrophage quality assures normal blood stem cells use one of these eat me signals that is
important to determine the number of hematopoietic clones that participate in adult hematopoiesis. More...
Macrophage quality assures normal blood stem cells use one of these eat me signals that is
important to determine the number of hematopoietic clones that participate in adult hematopoiesis.
Macrophages either engulf a stem cell completely (referred to as dooming) or capture portions of the
stem cell cellular material (referred to as grooming). In the latter case, the stem cell continues to divide.
This interaction is mediated by a signal called calreticulin (Calr) on the surface of hematopoietic stem and
progenitor cells (HSPCs), known as an eat-me signal. Surface Calr levels are increased in stem cells with
higher levels of reactive oxygen species (ROS), but the specific molecular cues that regulate the dooming
versus grooming behavior are still unknown. We found that b2 microglobulin (B2m) is a do not eat-me
molecule and show that both Calr and B2m must balance the eat me and do not eat me cues to quality
assure hematopoietic stem cells. Less...