BioProject

Pancreatic ductal adenocarcinoma is one of the most malignant tumors because of its high metastatic ability. More...

Pancreatic ductal adenocarcinoma is one of the most malignant tumors because of its high metastatic ability. The glutamine-deficient microenvironment contributes to PDAC metastasis; however, the underlying molecular mechanisms remain unclear. Gln deficiency in tumor progression is a long-term outcome, and PDAC cells proliferate within these microenvironments. We thus generated -QQ PANC-1 cells, which were cultured in the glutamine-deprivation medium for three months. -QQ cells were compared with parental PANC-1 cells in this project. Less...