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Accession: PRJNA1071201 ID: 1071201

Blocker-SELEX: A Structure-Guided Strategy for Developing Inhibitory Aptamers Disrupting Transcription Factor Interactions (human)

See Genome Information for Homo sapiens
Despite the well-established significance of transcription factors (TFs) in pathogenesis, their utilization as pharmacological targets has been limited by the inherent challenges mainly associated with modulating their protein-protein and protein-DNA interactions. More...
AccessionPRJNA1071201; GEO: GSE254651
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsLi T et al., "Blocker-SELEX: a structure-guided strategy for developing inhibitory aptamers disrupting undruggable transcription factor interactions.", Nat Commun, 2024 Aug 8;15(1):6751
SubmissionRegistration date: 30-Jan-2024
Hangzhou lnstitute of Medicine Chinese Academy of Sciences
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments6
Publications
PubMed1
PMC1
Other datasets
BioSample6
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes7
SRA Data Details
ParameterValue
Data volume, Gbases46
Data volume, Mbytes14978

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