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Genome Information for Homo sapiens
To uncover the mechanisms of MDM2 inhibitor resistance that are mediated by IL-1, we performed RNAseq on three primary AML patient cells treated with idasanutlin in the presence or absence of IL-1beta. These three leukemia samples were chosen because they exhibit high blast counts and are protected by IL-1beta when treated with idasanutlin, as determined by apoptosis assay. We observed that a majority of the major p53 pathway targets remained upregulated in the presence of IL-1beta. We next performed differential expressed gene (DEG) analysis following IL-1beta treatment with and without idasanutlin. IL-1beta treatment upregulated 3295, 1353, and 680 genes with >=1 Log2FC, in each of the three patient samples, and a significant majority of these genes (82%, 62.4%, and 47.6%)... (for more see dbGaP study page.)
Accession | PRJNA1047202; dbGaP: phs003479 |
Type | Umbrella project (Subtype:Authorized Access) |
Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
Submission | Registration date: 30-Nov-2023 NCI |
Relevance | Medical |
CEBP-Beta/IL-1-Beta/ TNF-alpha Feedback Loop Drives Drug Resistance to BCL2 and MDM2 Inhibitors in Monocytic Leukemia Cells encompasses the following sub-project:
Project Type | Number of Projects |
Phenotype or Genotype | 1 |
BioProject accession | Organism | Title |
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PRJNA1047203 | Homo sapiens | CEBP-Beta/IL-1-Beta/ TNF-alpha Feedback Loop Drives Drug Resistance to BCL2 and MDM2 Inhibitors in Monocytic Leukemia Cells (OREGON HEALTH & SCIENCE UNIVERSITY) |
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