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Accession: PRJNA1021544 ID: 1021544

Cryptic splicing mediates genetic and therapeutic perturbation of human gene expression levels

Nascent RNA sequencing in 86 YRI LCLs. Cut&Tag from 95 YRI LCLs.

Nonsense-mediated decay (NMD) is an RNA surveillance mechanism that degrades transcripts containing premature termination codons. More...

AccessionPRJNA1021544
Data TypeRaw sequence reads
ScopeMultispecies
PublicationsFair B et al., "Global impact of unproductive splicing on human gene expression.", Nat Genet, 2024 Sep;56(9):1851-1861
Grants
  • "Investigating the co-transcriptional impact of genetic variation on gene regulation and disease" (Grant ID R01GM130738, National Institute of Health)
  • "Novel methods to detect and interpret splicing quantitative trait loci" (Grant ID R01HG011067, National Institute of Health)
SubmissionRegistration date: 27-Sep-2023
University of Chicago
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments210
Publications
PubMed1
PMC1
Other datasets
BioSample95
GEO DataSets3
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes173
SRA Data Details
ParameterValue
Data volume, Gbases4,909
Data volume, Tbytes1.52

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