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IDs: 4687648 [UID] 4687648 [GenBank] 1533128 [RefSeq]
HPV60 was originally isolated from a keratinous plantar cyst composed of the wall of the squamous cell layer and the horny inner substance in the lower dermis displaying cytoplasmic amorphous eosinophilic inclusions and vacuolated structure with or without pyknotic ... nuclei. These morphological changes are not characteristic of skin lesions associated with other HPV types (1, 2, 3, 4, and 7). HPV 60 was found in three out of three other plantar cysts with similar pathological changes; a fourth cyst without the associated pathological changes as negative for HPV60. These results strongly suggest that HPV 60 has unique biological properties which can induce a plantar cyst. The HPV60 genome appeared to be in an episomal form. HPV 60 showed no similarity with other known prototypes (HPVs 1-59) by Southern blot analysis under stringent conditions. Phylogenetically, it is associated with HPV 4, 48, 50, and 65, a group of primarily cutaneous types. more
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