1P4R: Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD

PDB ID: 1P4RDownload
MMDB ID: 26815
PDB Deposition Date: 2003/4/23
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.55  Å
Source Organism:
Similar Structures:
Biological Unit for 1P4R: dimeric; determined by author and by software (PISA)
Molecular Components in 1P4R
Label Count Molecule
Proteins (2 molecules)
2
Bifunctional Purine Biosynthesis Protein Purh
(Gene symbol: ATIC)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
2
POTASSIUM IONPOTASSIUM ION
2
2
AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDEAMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
3
2
N-[(S)-(4-{[(2-AMINO-4-HYDROXYQUINAZOLIN-6-YL)(DIHYDROXY)-LAMBDA~4~-SULFANYL]AMINO}PHENYL)(HYDROXY)METHYL]-L-GLUTAMIC ACIDN-[(S)-(4-{[(2-AMINO-4-HYDROXYQUINAZOLIN-6-YL)(DIHYDROXY)-LAMBDA~4~-SULFANYL]AMINO}PHENYL)(HYDROXY)METHYL]-L-GLUTAMIC ACID
4
1
XANTHOSINE-5'-MONOPHOSPHATEXANTHOSINE-5'-MONOPHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303