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Conserved domains on  [gi|1863134206|ref|YP_009870340|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Heimyscus fumosus]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 8.28e-41

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 129.67  E-value: 8.28e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863134206  1 MTSAFLNLTLAFTLSLTGTLMFRSHLMSTLLCLEGMMLSLFIMISTTTLNSNSMISMPIPITIMVFAACEAAVGLALLVK 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1863134206 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 8.28e-41

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 129.67  E-value: 8.28e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863134206  1 MTSAFLNLTLAFTLSLTGTLMFRSHLMSTLLCLEGMMLSLFIMISTTTLNSNSMISMPIPITIMVFAACEAAVGLALLVK 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1863134206 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 1.04e-16

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 68.36  E-value: 1.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863134206  3 SAFLNLTLAFTLSLTGtLMFRSHLMSTLLCLEGMMLSLFIMISTTTLNSNSMISMPIPITIMVFAACEAAVGLALLVKVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYG-LLLRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 1863134206 83 NTYGTDYVQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 1.17e-05

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 40.05  E-value: 1.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863134206 12 FTLSLTGtLMFRSHLMSTLLCLEGMMLS---LFIMISTTTLNSNSMIsmpIPITIMVFAACEAAVGLALLVKVSNTYGTD 88
Cdd:COG0713   14 FAIGLYG-VLTRRNLIVVLMSIELMLNAvnlNLVAFSRYLGDLDGQV---FALFVIAVAAAEVAVGLAIIVALYRNRGTI 89


                 ....*...
gi 1863134206 89 YVQNLNLL 96
Cdd:COG0713   90 DVDDLNEL 97
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 8.28e-41

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 129.67  E-value: 8.28e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863134206  1 MTSAFLNLTLAFTLSLTGTLMFRSHLMSTLLCLEGMMLSLFIMISTTTLNSNSMISMPIPITIMVFAACEAAVGLALLVK 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1863134206 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.86e-27

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 95.80  E-value: 1.86e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863134206  1 MTSAFLNLTLAFTLSLTGTLMFRSHLMSTLLCLEGMMLSLFIMISTTTLNSNSMISMPIPITIMVFAACEAAVGLALLVK 80
Cdd:MTH00126   1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                         90
                 ....*....|....*...
gi 1863134206 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00126  81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.57e-25

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 89.52  E-value: 6.57e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863134206  1 MTSAFLNLTLAFTLSLTGTLMFRSHLMSTLLCLEGMMLSLFIMISTTTLNSNSMISMPIPITIMVFAACEAAVGLALLVK 80
Cdd:MTH00125   1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                         90
                 ....*....|....*...
gi 1863134206 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00125  81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.62e-20

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 78.49  E-value: 1.62e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863134206  1 MTSAFLNLTLAFTLSLTGTLMFRSHLMSTLLCLEGMMLSLFIMISTTTLNSNSMISMPIPITIMVFAACEAAVGLALLVK 80
Cdd:MTH00067   1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                         90
                 ....*....|....*...
gi 1863134206 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00067  81 TTRTHGTDHLKNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 1.04e-16

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 68.36  E-value: 1.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863134206  3 SAFLNLTLAFTLSLTGtLMFRSHLMSTLLCLEGMMLSLFIMISTTTLNSNSMISMPIPITIMVFAACEAAVGLALLVKVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYG-LLLRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 1863134206 83 NTYGTDYVQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 5-96 5.78e-12

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 56.49  E-value: 5.78e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863134206  5 FLNLTLAFTLSLTGTLMFRSHLMSTLLCLEGMMLSLFIMISTTTLNSNSMISMPIPITIMVFAACEAAVGLALLVKVSNT 84
Cdd:MTH00181   2 MFVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRT 81

                         90
                 ....*....|..
gi 1863134206 85 YGTDYVQNLNLL 96
Cdd:MTH00181  82 HGSDHLLKFNLL 93
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 3.73e-11

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 54.54  E-value: 3.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863134206  1 MTSAFLNLTLAFTLSLTGTLMFRSHLMSTLLCLEGMMLSLFIMISTTTLNSNSMISMPIPITIMVFAACEAAVGLALLVK 80
Cdd:MTH00043   1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                         90
                 ....*....|....*..
gi 1863134206 81 VSNTYGTDYVQNLNLLQ 97
Cdd:MTH00043  81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.91e-09

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 49.97  E-value: 1.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863134206  1 MTSAFLNLTLAFTLSLTGTLMFRSHLMSTLLCLEGMMLSLFIMISTTTLNSNSmiSMPIPITIMVFAACEAAVGLALLVK 80
Cdd:MTH00188   2 FFSMILVILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEK--ELYLSLVLLTFAACEASVGLALLVS 79

                         90
                 ....*....|....*...
gi 1863134206 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00188  80 LIRSHGSDYVSSLNLIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.65e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 47.53  E-value: 1.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863134206  1 MTSAFLNLTLAFTLSLTGTLMFRSHLMSTLLCLEGMMLSLFIMIstTTLNSNSMISMPIPITIMVFAACEAAVGLALLVK 80
Cdd:MTH00149   2 MFMLLLLSLFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMM--FSSSGLISFSSYLFLIILTFGACEASLGLSLLVS 79

                         90
                 ....*....|....*...
gi 1863134206 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00149  80 LIRLHGNDYVSSLSSLKF 97
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 1.17e-05

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 40.05  E-value: 1.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863134206 12 FTLSLTGtLMFRSHLMSTLLCLEGMMLS---LFIMISTTTLNSNSMIsmpIPITIMVFAACEAAVGLALLVKVSNTYGTD 88
Cdd:COG0713   14 FAIGLYG-VLTRRNLIVVLMSIELMLNAvnlNLVAFSRYLGDLDGQV---FALFVIAVAAAEVAVGLAIIVALYRNRGTI 89


                 ....*...
gi 1863134206 89 YVQNLNLL 96
Cdd:COG0713   90 DVDDLNEL 97
ND4L MTH00180
NADH dehydrogenase subunit 4L; Provisional
 12-97 3.56e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177231  Cd Length: 99  Bit Score: 38.86  E-value: 3.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863134206 12 FTLSLTGTLMFRSHLMSTLLCLEGMMLSLFIMISTTTLNSNSMISMPIPITIMVFAACEAAVGLALLVKVSNTYGTDYVQ 91
Cdd:MTH00180  13 FILGVLGIVLNRSNLIIMLMSIELMLLAISLLFLINSVAIDNLIGQIFTIMILTVAAAESAIGLAILVAYYRIRGTIAVK 92


                 ....*.
gi 1863134206 92 NLNLLQ 97
Cdd:MTH00180  93 SLNLLR 98
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 1.25e-04

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 37.42  E-value: 1.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863134206  1 MTSAFLNLTLAFTLSLTGTLMFRSHLMSTLLCLEGMMLSLFIMISTTTLNSNSMISMpIPITIMVFAACEAAVGLALLVK 80
Cdd:MTH00013   1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFANQVNGM-LAIVLLTFGACEASLGLSLLVL 79

                         90
                 ....*....|....*...
gi 1863134206 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00013  80 MTRSYGNDMLKSLTSNKC 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 12-92 1.48e-04

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 37.06  E-value: 1.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863134206 12 FTLSLTGTLMFRSHLMSTLLCLEGMMLSLFIMISTTTLNSNSMISMPIPitIMVFAACEAAVGLALLVKVSNTYGTDYVQ 91
Cdd:MTH00162  11 FFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLF--FLTFSVCEGALGLSILVSMIRSHGNDYFS 88


                 .
gi 1863134206 92 N 92
Cdd:MTH00162  89 S 89
ND4L MTH00001
NADH dehydrogenase subunit 4L; Provisional
 10-97 1.17e-03

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177099  Cd Length: 99  Bit Score: 35.04  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863134206 10 LAFTLSLTGTLMFRSHLMSTLLCLEGMMLSLFIMISTTTLNSNSMISMPIPITIMVFAACEAAVGLALLVKVSNTYGTDY 89
Cdd:MTH00001  11 ILFLLGIWGIILNRGHFIIMLVSIELVLLSTFFLFLINSIEIDLLIEQIFTIMGLTIAAAESAIGLAIMVAYYRIRGTIS 90


                 ....*...
gi 1863134206 90 VQNLNLLQ 97
Cdd:MTH00001  91 LKSLNSLR 98
PRK05715 PRK05715
NADH-quinone oxidoreductase subunit NuoK;
12-96 4.89e-03

NADH-quinone oxidoreductase subunit NuoK;


Pssm-ID: 180218  Cd Length: 100  Bit Score: 33.23  E-value: 4.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863134206  12 FTLSLTGtLMFRSHLMSTLLCLEGMMLSL---FIMISTTTLNSNSMIsmpIPITIMVFAACEAAVGLALLVKVSNTYGTD 88
Cdd:PRK05715   15 FCIGLVG-LLLRRNAIVVLMSIELMLNAVnlnFVAFSSYLGDLDGQV---FAFFVITVAAAEAAIGLAILLQLYRNRGTI 90


                  ....*...
gi 1863134206  89 YVQNLNLL 96
Cdd:PRK05715   91 DVDDLNEL 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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