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Conserved domains on  [gi|428782009|ref|YP_007111773|]
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HNH endonuclease [Enterobacteria phage HK140]

Protein Classification

HNH endonuclease( domain architecture ID 10003646)

HNH endonuclease contains an HNH endonuclease signature motif and may catalyze the hydrolysis of DNA

Gene Ontology:  GO:0004519|GO:0003676|GO:0008270
PubMed:  28211904

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
6-83 7.42e-08

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


:

Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 45.74  E-value: 7.42e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 428782009   6 RVYGSRWDKARLRFLQ-QHPLCVMCEQQGRITPATVvDHIVPHKlkdalKSGNplaiskaqllfWSKENWQPLCKAHHD 83
Cdd:COG1403    1 RRPGREWPALRRAVLKrDNGRCQYCGRPFSGDALEV-DHIIPRS-----RGGT-----------DTWENLVLLCRRCNR 62
 
Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
6-83 7.42e-08

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 45.74  E-value: 7.42e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 428782009   6 RVYGSRWDKARLRFLQ-QHPLCVMCEQQGRITPATVvDHIVPHKlkdalKSGNplaiskaqllfWSKENWQPLCKAHHD 83
Cdd:COG1403    1 RRPGREWPALRRAVLKrDNGRCQYCGRPFSGDALEV-DHIIPRS-----RGGT-----------DTWENLVLLCRRCNR 62
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 13-84 1.56e-06

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 42.07  E-value: 1.56e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 428782009  13 DKARLRFLQQHPLCVMCEQQGrITPATVVDHIVPHKLKdalksgnplaiskaqlLFWSKENWQPLCKAHHDS 84
Cdd:cd00085    1 RSHRLVLLARDGLCPYCGKPG-GTEGLEVDHIIPLSDG----------------GNNDLDNLVLLCRKCHRK 55
HNHc smart00507
HNH nucleases;
14-83 6.80e-05

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 37.82  E-value: 6.80e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428782009    14 KARLRFLQQHPLCVMCEQQgrITPATVVDHIVPHKLKDAlksgnplaiskaqllfWSKENWQPLCKAHHD 83
Cdd:smart00507   1 KLRRLLLHRDGVCAYCGKP--ASEGLEVDHIIPLSDGGN----------------DDLDNLVLLCPKCHI 52
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 26-83 5.00e-03

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 32.71  E-value: 5.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 428782009   26 CVMCEQQGRITPATVVDHIVPHKLKDALksgnplaiskaqllfwSKENWQPLCKAHHD 83
Cdd:pfam01844   1 CQYCGRPFHISDALTVDHIIPLSDGGAD----------------DIENLILLCPSCHN 42
 
Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
6-83 7.42e-08

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 45.74  E-value: 7.42e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 428782009   6 RVYGSRWDKARLRFLQ-QHPLCVMCEQQGRITPATVvDHIVPHKlkdalKSGNplaiskaqllfWSKENWQPLCKAHHD 83
Cdd:COG1403    1 RRPGREWPALRRAVLKrDNGRCQYCGRPFSGDALEV-DHIIPRS-----RGGT-----------DTWENLVLLCRRCNR 62
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 13-84 1.56e-06

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 42.07  E-value: 1.56e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 428782009  13 DKARLRFLQQHPLCVMCEQQGrITPATVVDHIVPHKLKdalksgnplaiskaqlLFWSKENWQPLCKAHHDS 84
Cdd:cd00085    1 RSHRLVLLARDGLCPYCGKPG-GTEGLEVDHIIPLSDG----------------GNNDLDNLVLLCRKCHRK 55
HNHc smart00507
HNH nucleases;
14-83 6.80e-05

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 37.82  E-value: 6.80e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428782009    14 KARLRFLQQHPLCVMCEQQgrITPATVVDHIVPHKLKDAlksgnplaiskaqllfWSKENWQPLCKAHHD 83
Cdd:smart00507   1 KLRRLLLHRDGVCAYCGKP--ASEGLEVDHIIPLSDGGN----------------DDLDNLVLLCPKCHI 52
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 26-83 5.00e-03

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 32.71  E-value: 5.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 428782009   26 CVMCEQQGRITPATVVDHIVPHKLKDALksgnplaiskaqllfwSKENWQPLCKAHHD 83
Cdd:pfam01844   1 CQYCGRPFHISDALTVDHIIPLSDGGAD----------------DIENLILLCPSCHN 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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