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Conserved domains on  [gi|375137039|ref|YP_004997689|]
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putative acyltransferase [Acinetobacter pittii PHEA-2]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 11415180)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid; 1-acyl-sn-glycerol-3-phosphate acyltransferase, for example, converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position by utilizing either acyl-CoA or acyl-ACP as the fatty acyl donor;

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0008654|GO:0016746
PubMed:  18718904|18931347
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 67-266 3.42e-36

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 128.20  E-value: 3.42e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039  67 FKGFTDMMVKLGIMTYSVEGLEKLQNSRQELVIANHPTLIDVVVLIGMMQ-QANCVVKQSLWSNPFTKGPVQSAGYILN- 144
Cdd:COG0204   16 VRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPrPVRFVAKKELFKIPLLGWLLRALGAIPVd 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039 145 ----AGSQQFVEDCVKRLKENNaaSLLIFPEGTRTEKGmTLNEFQRGAANIAIRANVPIRPVIITCTPSTLTKNEKWYhv 220
Cdd:COG0204   96 rskrRAALRALRQAVEALKAGE--SLVIFPEGTRSPDG-RLLPFKTGAARLALEAGVPIVPVAIDGTERALPKGFLPR-- 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 375137039 221 psqPFHIEVKVLDAVQVSDLlddltvGPKQVRQLSRSFYKIFDEEL 266
Cdd:COG0204  171 ---PGKVTVRIGPPIDPSDL------EGEDRRELAERLRAAIEALL 207
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 67-266 3.42e-36

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 128.20  E-value: 3.42e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039  67 FKGFTDMMVKLGIMTYSVEGLEKLQNSRQELVIANHPTLIDVVVLIGMMQ-QANCVVKQSLWSNPFTKGPVQSAGYILN- 144
Cdd:COG0204   16 VRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPrPVRFVAKKELFKIPLLGWLLRALGAIPVd 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039 145 ----AGSQQFVEDCVKRLKENNaaSLLIFPEGTRTEKGmTLNEFQRGAANIAIRANVPIRPVIITCTPSTLTKNEKWYhv 220
Cdd:COG0204   96 rskrRAALRALRQAVEALKAGE--SLVIFPEGTRSPDG-RLLPFKTGAARLALEAGVPIVPVAIDGTERALPKGFLPR-- 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 375137039 221 psqPFHIEVKVLDAVQVSDLlddltvGPKQVRQLSRSFYKIFDEEL 266
Cdd:COG0204  171 ---PGKVTVRIGPPIDPSDL------EGEDRRELAERLRAAIEALL 207
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 73-243 2.75e-33

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 119.68  E-value: 2.75e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039  73 MMVKLGIMTYSVEGLEKLQNSRQELVIANHPTLIDVVVLIGMMQ-QANCVVKQSLWSNPFTKGPVQSAGYIL-----NAG 146
Cdd:cd07989    3 LLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPrPIRFVAKKELFKIPFLGWLLRLLGAIPidrgnGRS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039 147 SQQFVEDCVKRLKENNaaSLLIFPEGTRTEKGmTLNEFQRGAANIAIRANVPIRPVIITCTPSTLTKNEKWYHvpsqPFH 226
Cdd:cd07989   83 AREALREAIEALKEGE--SVVIFPEGTRSRDG-ELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPR----PGR 155

                        170
                 ....*....|....*..
gi 375137039 227 IEVKVLDAVQVSDLLDD 243
Cdd:cd07989  156 VTVRIGEPIPPEGLELA 172
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 97-207 1.52e-18

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 78.94  E-value: 1.52e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039    97 LVIANHPTLIDVVVLIGMMQQANC----VVKQSLWSNPFTKGPVQSAGYIL-----NAGSQQFVEDCVKRLKENNaaSLL 167
Cdd:smart00563   2 LVVANHQSFLDPLVLSALLPRKLGrvrfVAKKELFYVPLLGWLLRLLGAIFidrsnGRKARAALREAVELLKEGE--WLL 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 375137039   168 IFPEGTRTEKGmTLNEFQRGAANIAIRANVPIRPVIITCT 207
Cdd:smart00563  80 IFPEGTRSRPG-KLLPFKKGAARLALEAGVPIVPVAIRGT 118
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 84-204 2.75e-18

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 78.47  E-value: 2.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039   84 VEGLEKLQNSRQELVIANHPTLIDVVVLIGMMQQANC----VVKQSLWSNPFTKGPVQSAGYI-----LNAGSQQFVEDC 154
Cdd:pfam01553   4 VHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKRGRplvfVAKKELFDIPLVGWLMRLLGCIfidrkNRKDAAGTLEYL 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 375137039  155 VKRLKENNaaSLLIFPEGTRTEKGMTLnEFQRGAANIAIRANVPIRPVII 204
Cdd:pfam01553  84 VELLREGK--LVVIFPEGTRSREGELL-PFKKGAFRLAIEAGVPIVPVAI 130
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 97-204 1.30e-15

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 71.22  E-value: 1.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039   97 LVIANHPTLIDVVVLIGMMQQANCVV-KQSLWSNPFTKGPVQSAG-YILNAGSQQ----FVEDCVKRLKENNaaSLLIFP 170
Cdd:TIGR00530  19 LVVANHQSNLDPLTLSAAFPPPIVFIaKKELKWIPFFGIMLWLTGaIFIDRENIRaiatALKAAIEVLKQGR--SIGVFP 96

                          90       100       110
                  ....*....|....*....|....*....|....
gi 375137039  171 EGTRTeKGMTLNEFQRGAANIAIRANVPIRPVII 204
Cdd:TIGR00530  97 EGTRS-RGRDILPFKKGAFHIAIKAGVPILPVVL 129
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 84-204 4.59e-10

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 57.82  E-value: 4.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039  84 VEGLEKLQNSRQELV-IANHPTLIDVVVLIGMMQQANCVVKQSLWSNPFTKGPVQSAGYI----LNAGSQQfveDCVKRL 158
Cdd:PLN02901  39 VEGLENLPSPDEPAVyVSNHQSFLDIYTLFHLGRPFKFISKTSIFLIPIIGWAMYMTGHIplkrMDRRSQL---ECLKRC 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 375137039 159 KE--NNAASLLIFPEGTRTEKGmTLNEFQRGAANIAIRANVPIRPVII 204
Cdd:PLN02901 116 MEllKKGASVFFFPEGTRSKDG-KLAAFKKGAFSVAAKTGVPVVPITL 162
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 67-266 3.42e-36

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 128.20  E-value: 3.42e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039  67 FKGFTDMMVKLGIMTYSVEGLEKLQNSRQELVIANHPTLIDVVVLIGMMQ-QANCVVKQSLWSNPFTKGPVQSAGYILN- 144
Cdd:COG0204   16 VRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPrPVRFVAKKELFKIPLLGWLLRALGAIPVd 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039 145 ----AGSQQFVEDCVKRLKENNaaSLLIFPEGTRTEKGmTLNEFQRGAANIAIRANVPIRPVIITCTPSTLTKNEKWYhv 220
Cdd:COG0204   96 rskrRAALRALRQAVEALKAGE--SLVIFPEGTRSPDG-RLLPFKTGAARLALEAGVPIVPVAIDGTERALPKGFLPR-- 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 375137039 221 psqPFHIEVKVLDAVQVSDLlddltvGPKQVRQLSRSFYKIFDEEL 266
Cdd:COG0204  171 ---PGKVTVRIGPPIDPSDL------EGEDRRELAERLRAAIEALL 207
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 73-243 2.75e-33

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 119.68  E-value: 2.75e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039  73 MMVKLGIMTYSVEGLEKLQNSRQELVIANHPTLIDVVVLIGMMQ-QANCVVKQSLWSNPFTKGPVQSAGYIL-----NAG 146
Cdd:cd07989    3 LLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPrPIRFVAKKELFKIPFLGWLLRLLGAIPidrgnGRS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039 147 SQQFVEDCVKRLKENNaaSLLIFPEGTRTEKGmTLNEFQRGAANIAIRANVPIRPVIITCTPSTLTKNEKWYHvpsqPFH 226
Cdd:cd07989   83 AREALREAIEALKEGE--SVVIFPEGTRSRDG-ELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPR----PGR 155

                        170
                 ....*....|....*..
gi 375137039 227 IEVKVLDAVQVSDLLDD 243
Cdd:cd07989  156 VTVRIGEPIPPEGLELA 172
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 97-207 1.52e-18

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 78.94  E-value: 1.52e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039    97 LVIANHPTLIDVVVLIGMMQQANC----VVKQSLWSNPFTKGPVQSAGYIL-----NAGSQQFVEDCVKRLKENNaaSLL 167
Cdd:smart00563   2 LVVANHQSFLDPLVLSALLPRKLGrvrfVAKKELFYVPLLGWLLRLLGAIFidrsnGRKARAALREAVELLKEGE--WLL 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 375137039   168 IFPEGTRTEKGmTLNEFQRGAANIAIRANVPIRPVIITCT 207
Cdd:smart00563  80 IFPEGTRSRPG-KLLPFKKGAARLALEAGVPIVPVAIRGT 118
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 84-204 2.75e-18

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 78.47  E-value: 2.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039   84 VEGLEKLQNSRQELVIANHPTLIDVVVLIGMMQQANC----VVKQSLWSNPFTKGPVQSAGYI-----LNAGSQQFVEDC 154
Cdd:pfam01553   4 VHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKRGRplvfVAKKELFDIPLVGWLMRLLGCIfidrkNRKDAAGTLEYL 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 375137039  155 VKRLKENNaaSLLIFPEGTRTEKGMTLnEFQRGAANIAIRANVPIRPVII 204
Cdd:pfam01553  84 VELLREGK--LVVIFPEGTRSREGELL-PFKKGAFRLAIEAGVPIVPVAI 130
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 97-204 1.30e-15

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 71.22  E-value: 1.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039   97 LVIANHPTLIDVVVLIGMMQQANCVV-KQSLWSNPFTKGPVQSAG-YILNAGSQQ----FVEDCVKRLKENNaaSLLIFP 170
Cdd:TIGR00530  19 LVVANHQSNLDPLTLSAAFPPPIVFIaKKELKWIPFFGIMLWLTGaIFIDRENIRaiatALKAAIEVLKQGR--SIGVFP 96

                          90       100       110
                  ....*....|....*....|....*....|....
gi 375137039  171 EGTRTeKGMTLNEFQRGAANIAIRANVPIRPVII 204
Cdd:TIGR00530  97 EGTRS-RGRDILPFKKGAFHIAIKAGVPILPVVL 129
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 83-229 3.09e-12

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 63.59  E-value: 3.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039  83 SVEGLEKLQNSRQELVIANHPTLIDVVVLIGMMQ-----QANCVVKQSLWSN--PFTKG---PVQSAGYILNAGSQQFVe 152
Cdd:cd06551   15 EVKGPPPPPGGGPVLFVSNHSSWWDGLILFLLLErglrrDVYGLMDEELLERypFFTRLgafSVDRDSPRSAAKSLKYV- 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 375137039 153 dcVKRLKENNAAsLLIFPEGTRTEKGMTLNEFQRGAANIAIRANVPIRPVIITCTPstltknekWYHVPSQPFHIEV 229
Cdd:cd06551   94 --ARLLSKPGSV-VWIFPEGTRTRRDKRPLQFKPGVAHLAEKAGVPIVPVALRYTF--------ELFEQFPEIFVRI 159
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 84-204 4.59e-10

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 57.82  E-value: 4.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039  84 VEGLEKLQNSRQELV-IANHPTLIDVVVLIGMMQQANCVVKQSLWSNPFTKGPVQSAGYI----LNAGSQQfveDCVKRL 158
Cdd:PLN02901  39 VEGLENLPSPDEPAVyVSNHQSFLDIYTLFHLGRPFKFISKTSIFLIPIIGWAMYMTGHIplkrMDRRSQL---ECLKRC 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 375137039 159 KE--NNAASLLIFPEGTRTEKGmTLNEFQRGAANIAIRANVPIRPVII 204
Cdd:PLN02901 116 MEllKKGASVFFFPEGTRSKDG-KLAAFKKGAFSVAAKTGVPVVPITL 162
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 77-239 1.19e-08

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 53.76  E-value: 1.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039  77 LGIMTYSVEGLEKLQNSRQeLVIANHPTLIDVVVLIgMMQQANCVVKQSLWSNPFTKGPVQSAGYIL----NAGSQQFVe 152
Cdd:cd07991    8 FGFYVIKVHGKPDPPEAPR-IIVANHTSFIDPLILF-SDLFPSIVAKKELGKLPFIGTILRALGCIFvdrsEPKDRKKV- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039 153 dcVKRLKE----NNAASLLIFPEGTRTeKGMTLNEFQRGAANIAiranVPIRPVII--TCTPSTLTKN-------EKWYH 219
Cdd:cd07991   85 --VEEIKEratdPNWPPILIFPEGTTT-NGKALIMFKKGAFEPG----VPVQPVAIryPNKFVDAFWNssgysslMYLFR 157

                        170       180
                 ....*....|....*....|.
gi 375137039 220 VPSQPF-HIEVKVLDAVQVSD 239
Cdd:cd07991  158 LLTQPAnVLEVEFLPVYTPSE 178
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 82-204 3.58e-07

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 49.59  E-value: 3.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039  82 YSVEGLEKLQNSRQELVIANHPTL-IDVVVLIGMMQQAN------CVVKQSLWSNPFTKGPVQSAGYIlnAGSqqfVEDC 154
Cdd:cd07987    8 YEVRGLENIPDEGPALLVHPHGGLpIDGALLAAAFLLLFpgrlprALADHFLFPLPGLRDLLRRLGAV--PGS---RENC 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 375137039 155 VKRLKENNAasLLIFPEGTR------TEKGMTLNEFQRGAANIAIRANVPIRPVII 204
Cdd:cd07987   83 VRLLREGEL--VLIFPGGARealkskREEYYLLWKKRKGFARLALRAGAPIVPVFT 136
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 84-204 3.88e-06

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 48.00  E-value: 3.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039   84 VEGLEKLQNSRQELVIANHPTLIDVVVLIGMMQQA-NCVVKQSLWSNPFTKG--------PVQSAGyilnagSQQFVEDC 154
Cdd:PRK08633  431 VEGRENIPAKGGALLLGNHVSWIDWALLQAASPRPiRFVMERSIYEKWYLKWffklfgviPISSGG------SKESLEFI 504

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 375137039  155 VKRLKENNAasLLIFPEGTRTEKGMtLNEFQRGAANIAIRANVPIRPVII 204
Cdd:PRK08633  505 RKALDDGEV--VCIFPEGAITRNGQ-LNEFKRGFELIVKGTDVPIIPFYI 551
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 97-177 1.46e-05

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 44.54  E-value: 1.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039  97 LVIANHPTLIDVVVLIGMMQQAN------CVVKQSL-------WSNpftkgpvQSAGYI-LN---AGSQQFVEDCVKRLK 159
Cdd:cd07990   27 LIISNHRSEVDWLVLWMLADRFGrlgrlkIVLKDSLkypplggWGW-------QLGEFIfLKrkwEKDEKTIKRQLKRLK 99

                         90       100
                 ....*....|....*....|
gi 375137039 160 E-NNAASLLIFPEGTR-TEK 177
Cdd:cd07990  100 DsPEPFWLLIFPEGTRfTEE 119
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 97-267 1.97e-05

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 44.62  E-value: 1.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039  97 LVIANHPTLIDVVVLIGMMQQANCVV-KQSLWSNPFTKGPVQSAGYIL-----NAGSQQFVEDCVKRLKENNAaSLLIFP 170
Cdd:PRK15018  68 IYIANHQNNYDMVTASNIVQPPTVTVgKKSLLWIPFFGQLYWLTGNLLidrnnRTKAHGTIAEVVNHFKKRRI-SIWMFP 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039 171 EGTRTeKGMTLNEFQRGAANIAIRANVPIRPVIITCTPSTLTKNEKWYHVpsqpfhIEVKVLDAVQVSDLlddltvGPKQ 250
Cdd:PRK15018 147 EGTRS-RGRGLLPFKTGAFHAAIAAGVPIIPVCVSTTSNKINLNRLHNGL------VIVEMLPPIDVSQY------GKDQ 213

                        170
                 ....*....|....*..
gi 375137039 251 VRQLSRSFYKIFDEELS 267
Cdd:PRK15018 214 VRELAAHCRSIMEQKIA 230
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 83-202 2.50e-05

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 44.17  E-value: 2.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039  83 SVEGLEKLQNSRQELVIANHP-TLIDVVVLIGMM-QQANCVVKQSLWSNPFTKGPVQSAGYI------------LNAGSQ 148
Cdd:cd07992   17 TVVGRENVPKDGPVIFLGNHPnALIDPLLLAATLrRPVRFLAKADLFKNPLIGWLLESFGAIpvyrpkdlarggIGKISN 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039 149 QFVEDCVKRLKENNAAsLLIFPEGTrTEKGMTLNEFQRGAANIAIRA------NVPIRPV 202
Cdd:cd07992   97 AAVFDAVGEALKAGGA-IGIFPEGG-SHDRPRLLPLKAGAARMALEAleagqkDVKIVPV 154
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
22-204 3.00e-05

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 44.96  E-value: 3.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039   22 ATGFSFASFgLGGMAIASVIAPVLNATTsDPQkrqqraqNVIKHSFKGFTDMMVKLgimtySVEGLEKLQNSRQELVIA- 100
Cdd:PRK06814  395 ALGFSIPWI-ILFIALANLIVAILILRL-LPT-------NLLRDIFSILFRAFYRV-----EVKGLENLQKAGKKAVIAa 460

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039  101 NHPTLID----VVVLIGMMQQA-NCVVKQSLWSNPFTKgpVQSAgYILNAGSQQFVEDCVKRLKENNaaSLLIFPEGTRT 175
Cdd:PRK06814  461 NHVSFLDgpllAAYLPEEPTFAiDTDIAKAWWVKPFLK--LAKA-LPVDPTNPMATRTLIKEVQKGE--KLVIFPEGRIT 535

                         170       180       190
                  ....*....|....*....|....*....|.
gi 375137039  176 EKG--MTLNEfqrGAANIAIRANVPIRPVII 204
Cdd:PRK06814  536 VTGslMKIYD---GPGMIADKAGAMVVPVRI 563
PLN02833 PLN02833
glycerol acyltransferase family protein
 99-196 9.22e-03

glycerol acyltransferase family protein


Pssm-ID: 215447  Cd Length: 376  Bit Score: 37.06  E-value: 9.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375137039  99 IANHPTLIDVVVLIGMMQQANCVVKQSLWSNPFTKGPVQSAGYI-LNAGSQQFVEDCVKRLKE--NNAAS--LLIFPEGT 173
Cdd:PLN02833 168 VANHTSMIDFIVLEQMTPFAVIMQKHPGWVGFLQNTILESVGCIwFNRTEAKDREVVAKKLRDhvQDPDRnpLLIFPEGT 247

                         90       100       110
                 ....*....|....*....|....*....|
gi 375137039 174 RTEKGMTLnEFQRGAAN-------IAIRAN 196
Cdd:PLN02833 248 CVNNEYTV-MFKKGAFElgctvcpIAIKYN 276
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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