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Conserved domains on  [gi|326784401|ref|YP_004324645|]
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2OG-Fe(II) oxygenase [Synechococcus phage S-SSM5]

Protein Classification

2OG-Fe(II) oxygenase( domain architecture ID 10614554)

2OG-Fe(II) oxygenase belonging to the large and diverse Fe(II)- and 2-oxoglutarate (2-OG)-dependent dioxygenase superfamily that share a common reaction mechanism, using Fe(II) and the cosubstrate 2-OG in the active site to activate oxygen, resulting in the two-electron oxidation of the target substrate

CATH:  2.60.120.620
EC:  1.14.11.-
Gene Ontology:  GO:0008198|GO:0016705
PubMed:  11276424

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2OG-FeII_Oxy_3 pfam13640
2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and ...
86-179 2.98e-22

2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily.


:

Pssm-ID: 463943  Cd Length: 94  Bit Score: 85.89  E-value: 2.98e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326784401   86 IQYTVYEKGQYYNWHQDATIESVGEDNklRKLSFILQLSSPDEYQGGNIEMKTTDDNVYLVPrRRGTLIVFDSRTI--HR 163
Cdd:pfam13640   1 LQLARYGDGGFYKPHLDFFEGAEGGGQ--RRLTVVLYLNDWEEEEGGELVLYDGDGVEDIKP-KKGRLVLFPSSELslHE 77
                          90
                  ....*....|....*.
gi 326784401  164 VTEVTGGIRKTLVGWV 179
Cdd:pfam13640  78 VLPVTGGERWSITGWF 93
 
Name Accession Description Interval E-value
2OG-FeII_Oxy_3 pfam13640
2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and ...
86-179 2.98e-22

2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily.


Pssm-ID: 463943  Cd Length: 94  Bit Score: 85.89  E-value: 2.98e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326784401   86 IQYTVYEKGQYYNWHQDATIESVGEDNklRKLSFILQLSSPDEYQGGNIEMKTTDDNVYLVPrRRGTLIVFDSRTI--HR 163
Cdd:pfam13640   1 LQLARYGDGGFYKPHLDFFEGAEGGGQ--RRLTVVLYLNDWEEEEGGELVLYDGDGVEDIKP-KKGRLVLFPSSELslHE 77
                          90
                  ....*....|....*.
gi 326784401  164 VTEVTGGIRKTLVGWV 179
Cdd:pfam13640  78 VLPVTGGERWSITGWF 93
PRK05467 PRK05467
Fe(II)-dependent oxygenase superfamily protein; Provisional
91-179 1.05e-14

Fe(II)-dependent oxygenase superfamily protein; Provisional


Pssm-ID: 235483 [Multi-domain]  Cd Length: 226  Bit Score: 69.09  E-value: 1.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326784401  91 YEKGQYYNWHQDATIESV-GEDNKLRK-LSFILQLSSPDEYQGGNIEMKTTDDN--VYLVPrrrGTLIVFDSRTIHRVTE 166
Cdd:PRK05467  87 YEGGMSYGFHVDNAVRSLpGTGGRVRTdLSATLFLSDPDDYDGGELVIEDTYGEhrVKLPA---GDLVLYPSTSLHRVTP 163
                         90
                 ....*....|...
gi 326784401 167 VTGGIRKTLVGWV 179
Cdd:PRK05467 164 VTRGVRVASFFWI 176
PiuC COG3128
Predicted 2-oxoglutarate- and Fe(II)-dependent dioxygenase YbiX [General function prediction ...
91-179 4.02e-13

Predicted 2-oxoglutarate- and Fe(II)-dependent dioxygenase YbiX [General function prediction only];


Pssm-ID: 442362 [Multi-domain]  Cd Length: 225  Bit Score: 64.78  E-value: 4.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326784401  91 YEKGQYYNWHQDATIESV-GEDNKLRK-LSFILQLSSPDEYQGGNIEMKTTDDnvylvPRR----RGTLIVFDSRTIHRV 164
Cdd:COG3128   86 YEGGMHYGNHVDNAIRGLpGTGQRVRTdLSFTLFLSDPDEYDGGELVIEDTYG-----EQSvklpAGDMVLYPSTSLHRV 160
                         90
                 ....*....|....*
gi 326784401 165 TEVTGGIRKTLVGWV 179
Cdd:COG3128  161 TPVTRGERLASFFWI 175
P4Hc smart00702
Prolyl 4-hydroxylase alpha subunit homologues; Mammalian enzymes catalyse hydroxylation of ...
43-180 2.17e-08

Prolyl 4-hydroxylase alpha subunit homologues; Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglutarate and dioxygen as cosubstrates and ferrous iron as a cofactor.


Pssm-ID: 214780  Cd Length: 165  Bit Score: 51.23  E-value: 2.17e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326784401    43 KTRDSQTSWIPATNwvGGFCMSYVLKANRENYQYDIEGIDQDE-IQYTVYEKGQYYNWHQDAtieSVGEDnklRKLSFIL 121
Cdd:smart00702  33 QYRQSNGTWLELLE--RDLVIERIRQRLADFLGLLAGLPLSAEdAQVARYGPGGHYGPHVDN---FLYGD---RIATFIL 104
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 326784401   122 QLSspDEYQGGNIEMKTTDDNVYLVPR-RRGTLIVF---DSRTIHRVTEVTGGIRKTLVGWVT 180
Cdd:smart00702 105 YLN--DVEEGGELVFPGLRLMVVATVKpKKGDLLFFpsgHGRSLHGVCPVTRGSRWAITGWIR 165
 
Name Accession Description Interval E-value
2OG-FeII_Oxy_3 pfam13640
2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and ...
86-179 2.98e-22

2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily.


Pssm-ID: 463943  Cd Length: 94  Bit Score: 85.89  E-value: 2.98e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326784401   86 IQYTVYEKGQYYNWHQDATIESVGEDNklRKLSFILQLSSPDEYQGGNIEMKTTDDNVYLVPrRRGTLIVFDSRTI--HR 163
Cdd:pfam13640   1 LQLARYGDGGFYKPHLDFFEGAEGGGQ--RRLTVVLYLNDWEEEEGGELVLYDGDGVEDIKP-KKGRLVLFPSSELslHE 77
                          90
                  ....*....|....*.
gi 326784401  164 VTEVTGGIRKTLVGWV 179
Cdd:pfam13640  78 VLPVTGGERWSITGWF 93
PRK05467 PRK05467
Fe(II)-dependent oxygenase superfamily protein; Provisional
91-179 1.05e-14

Fe(II)-dependent oxygenase superfamily protein; Provisional


Pssm-ID: 235483 [Multi-domain]  Cd Length: 226  Bit Score: 69.09  E-value: 1.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326784401  91 YEKGQYYNWHQDATIESV-GEDNKLRK-LSFILQLSSPDEYQGGNIEMKTTDDN--VYLVPrrrGTLIVFDSRTIHRVTE 166
Cdd:PRK05467  87 YEGGMSYGFHVDNAVRSLpGTGGRVRTdLSATLFLSDPDDYDGGELVIEDTYGEhrVKLPA---GDLVLYPSTSLHRVTP 163
                         90
                 ....*....|...
gi 326784401 167 VTGGIRKTLVGWV 179
Cdd:PRK05467 164 VTRGVRVASFFWI 176
PiuC COG3128
Predicted 2-oxoglutarate- and Fe(II)-dependent dioxygenase YbiX [General function prediction ...
91-179 4.02e-13

Predicted 2-oxoglutarate- and Fe(II)-dependent dioxygenase YbiX [General function prediction only];


Pssm-ID: 442362 [Multi-domain]  Cd Length: 225  Bit Score: 64.78  E-value: 4.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326784401  91 YEKGQYYNWHQDATIESV-GEDNKLRK-LSFILQLSSPDEYQGGNIEMKTTDDnvylvPRR----RGTLIVFDSRTIHRV 164
Cdd:COG3128   86 YEGGMHYGNHVDNAIRGLpGTGQRVRTdLSFTLFLSDPDEYDGGELVIEDTYG-----EQSvklpAGDMVLYPSTSLHRV 160
                         90
                 ....*....|....*
gi 326784401 165 TEVTGGIRKTLVGWV 179
Cdd:COG3128  161 TPVTRGERLASFFWI 175
EGL9 COG3751
Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain ...
87-178 3.38e-11

Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442965 [Multi-domain]  Cd Length: 195  Bit Score: 59.19  E-value: 3.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326784401  87 QYTVYEKGQYYNWHQDAtiesvGEDNKLRKLSFILQLSS-PDEYQGGNIEMKTTDDN---VYLVPrRRGTLIVFDSRTI- 161
Cdd:COG3751  102 HFARYPPGGFYKRHLDA-----FRGDLNRRLSLVLYLNPdWQPEWGGELELYDDDGSeeeVTVAP-RFNRLVLFLSEEFp 175
                         90
                 ....*....|....*..
gi 326784401 162 HRVTEVTGGiRKTLVGW 178
Cdd:COG3751  176 HEVLPVGRE-RLSIAGW 191
P4Hc smart00702
Prolyl 4-hydroxylase alpha subunit homologues; Mammalian enzymes catalyse hydroxylation of ...
43-180 2.17e-08

Prolyl 4-hydroxylase alpha subunit homologues; Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglutarate and dioxygen as cosubstrates and ferrous iron as a cofactor.


Pssm-ID: 214780  Cd Length: 165  Bit Score: 51.23  E-value: 2.17e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326784401    43 KTRDSQTSWIPATNwvGGFCMSYVLKANRENYQYDIEGIDQDE-IQYTVYEKGQYYNWHQDAtieSVGEDnklRKLSFIL 121
Cdd:smart00702  33 QYRQSNGTWLELLE--RDLVIERIRQRLADFLGLLAGLPLSAEdAQVARYGPGGHYGPHVDN---FLYGD---RIATFIL 104
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 326784401   122 QLSspDEYQGGNIEMKTTDDNVYLVPR-RRGTLIVF---DSRTIHRVTEVTGGIRKTLVGWVT 180
Cdd:smart00702 105 YLN--DVEEGGELVFPGLRLMVVATVKpKKGDLLFFpsgHGRSLHGVCPVTRGSRWAITGWIR 165
2OG-FeII_Oxy_4 pfam13661
2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and ...
86-178 4.88e-04

2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily.


Pssm-ID: 433386  Cd Length: 98  Bit Score: 37.71  E-value: 4.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326784401   86 IQYTVYEKGQYYNWHQDaTIESvgednklRKLSFILQLSSP-DEYQGGNIEMKTTDDNVY-------LVPrRRGTLIVFD 157
Cdd:pfam13661   1 MSCSRYEKGDFLLCHDD-VIEG-------RRIAFILYLVENwKPDDGGALDLYDTDGHGQpaditksIVP-TWNKLVFFE 71
                          90       100
                  ....*....|....*....|....*
gi 326784401  158 SRTIHRVTEV----TGGIRKTLVGW 178
Cdd:pfam13661  72 VSPGHSFHQVaevvAEKPRLSISGW 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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