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Conserved domains on  [gi|134119100|ref|XP_771785|]
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hypothetical protein CNBN2300 [Cryptococcus neoformans var. neoformans B-3501A]

Protein Classification

1,3-beta-glucanosyltransferase( domain architecture ID 11042787)

1,3-beta-glucanosyltransferase splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_hydro super family cl23725
Glycosyl hydrolases; A functionally diverse superfamily containing glycosyl hydrolase families ...
 13-338 2.85e-113

Glycosyl hydrolases; A functionally diverse superfamily containing glycosyl hydrolase families 1,5,10,17,44,72, and others.


The actual alignment was detected with superfamily member pfam03198:

Pssm-ID: 474034 [Multi-domain]  Cd Length: 315  Bit Score: 339.74  E-value: 2.85e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134119100   13 FLAMTAALPNITRTG-KYLYDESGNRFYIKGVAYQPegelaassdansanGGFPEPSSFYDPLSSPQNCTRDLPYLQQLG 91
Cdd:pfam03198   2 TSAAFAATPPIEIKGnKFFDSKNGEQFYIKGVDYQP--------------GGSSENSTLVDPLADADVCKRDIPYFKELG 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134119100   92 VNAVRVYSVNSSLNHDDCMKMFNDAGIYVLLDVSLPlNGSIDRSSP--SWSTNLLNEYIETIDAFRSYGNVLGYNIGNEV 169
Cdd:pfam03198  68 INTIRVYAVDPSLNHDECMKALSDAGIYVILDLNTP-KESINRADPagSYNVDYLERYFAVIDAFKNYTNVLGFFAGNEV 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134119100  170 INLVSNTNAAPFVKAAARDIKAYLKSVGSSAL-VGYAAVDgESDFRNSLAEYLTCGGDSIAVDLYGLNNYEWCGNQNINS 248
Cdd:pfam03198 147 TNDASNTDASPYVKAAIRDMKQYISKHKYRTIpVGYSAAD-DADTRVQLADYFACGDDDERADFFGINMYEWCGYSSFKT 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134119100  249 SNWNTITEGFSDLPVATYMSEFGCITSPPRLWTEVAALFASPVSDVFSGGVAFSYFPTSDDYGMVTISDNDTVTVTDDFT 328
Cdd:pfam03198 226 SGYDDRTKEFENYSIPVFFSEYGCNKVTPRPFTEVSALYSSDMTSVFSGGLVYEYSEEANNYGLVSIDGDDVVTTLADFN 305

                         330
                  ....*....|
gi 134119100  329 RLATQYNSTS 338
Cdd:pfam03198 306 NLKSEYAKIS 315
X8 pfam07983
X8 domain; The X8 domain domain contains at least 6 conserved cysteine residues that ...
 385-468 6.62e-19

X8 domain; The X8 domain domain contains at least 6 conserved cysteine residues that presumably form three disulphide bridges. The domain is found in an Olive pollen allergen as well as at the C-terminus of several families of glycosyl hydrolases. This domain may be involved in carbohydrate binding. This domain is characteriztic of GPI-anchored domains.


:

Pssm-ID: 400371  Cd Length: 76  Bit Score: 81.11  E-value: 6.62e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134119100  385 LSCKVKqSSANSPEIvGALLDYACSLlgstnssASCDPIAGNGTSGTYGQLSFCSPAIKLSYVMSTYYQI-NPEDTSCDF 463
Cdd:pfam07983   1 LWCVAK-DSVDDEDL-QDLFDYACGQ-------ADCSGIQANGTTGKYGCYSPCTVKQHLSYAFNSYYQKqGKASSACDF 71


                  ....*
gi 134119100  464 AGNAS 468
Cdd:pfam07983  72 SGSAT 76
 
Name Accession Description Interval E-value
Glyco_hydro_72 pfam03198
Glucanosyltransferase; This is a family of glycosylphosphatidylinositol-anchored beta(1-3) ...
 13-338 2.85e-113

Glucanosyltransferase; This is a family of glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferases. The active site residues in the Aspergillus fumigatus example Swiss:B0XT72 are the two glutamate residues at 160 and 261.


Pssm-ID: 397351 [Multi-domain]  Cd Length: 315  Bit Score: 339.74  E-value: 2.85e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134119100   13 FLAMTAALPNITRTG-KYLYDESGNRFYIKGVAYQPegelaassdansanGGFPEPSSFYDPLSSPQNCTRDLPYLQQLG 91
Cdd:pfam03198   2 TSAAFAATPPIEIKGnKFFDSKNGEQFYIKGVDYQP--------------GGSSENSTLVDPLADADVCKRDIPYFKELG 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134119100   92 VNAVRVYSVNSSLNHDDCMKMFNDAGIYVLLDVSLPlNGSIDRSSP--SWSTNLLNEYIETIDAFRSYGNVLGYNIGNEV 169
Cdd:pfam03198  68 INTIRVYAVDPSLNHDECMKALSDAGIYVILDLNTP-KESINRADPagSYNVDYLERYFAVIDAFKNYTNVLGFFAGNEV 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134119100  170 INLVSNTNAAPFVKAAARDIKAYLKSVGSSAL-VGYAAVDgESDFRNSLAEYLTCGGDSIAVDLYGLNNYEWCGNQNINS 248
Cdd:pfam03198 147 TNDASNTDASPYVKAAIRDMKQYISKHKYRTIpVGYSAAD-DADTRVQLADYFACGDDDERADFFGINMYEWCGYSSFKT 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134119100  249 SNWNTITEGFSDLPVATYMSEFGCITSPPRLWTEVAALFASPVSDVFSGGVAFSYFPTSDDYGMVTISDNDTVTVTDDFT 328
Cdd:pfam03198 226 SGYDDRTKEFENYSIPVFFSEYGCNKVTPRPFTEVSALYSSDMTSVFSGGLVYEYSEEANNYGLVSIDGDDVVTTLADFN 305

                         330
                  ....*....|
gi 134119100  329 RLATQYNSTS 338
Cdd:pfam03198 306 NLKSEYAKIS 315
X8 pfam07983
X8 domain; The X8 domain domain contains at least 6 conserved cysteine residues that ...
 385-468 6.62e-19

X8 domain; The X8 domain domain contains at least 6 conserved cysteine residues that presumably form three disulphide bridges. The domain is found in an Olive pollen allergen as well as at the C-terminus of several families of glycosyl hydrolases. This domain may be involved in carbohydrate binding. This domain is characteriztic of GPI-anchored domains.


Pssm-ID: 400371  Cd Length: 76  Bit Score: 81.11  E-value: 6.62e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134119100  385 LSCKVKqSSANSPEIvGALLDYACSLlgstnssASCDPIAGNGTSGTYGQLSFCSPAIKLSYVMSTYYQI-NPEDTSCDF 463
Cdd:pfam07983   1 LWCVAK-DSVDDEDL-QDLFDYACGQ-------ADCSGIQANGTTGKYGCYSPCTVKQHLSYAFNSYYQKqGKASSACDF 71


                  ....*
gi 134119100  464 AGNAS 468
Cdd:pfam07983  72 SGSAT 76
X8 smart00768
Possibly involved in carbohydrate binding; The X8 domain, which may be involved in ...
 385-478 2.83e-10

Possibly involved in carbohydrate binding; The X8 domain, which may be involved in carbohydrate binding, is found in an Olive pollen antigen as well as at the C terminus of family 17 glycosyl hydrolases. It contains 6 conserved cysteine residues which presumably form three disulfide bridges.


Pssm-ID: 197867 [Multi-domain]  Cd Length: 85  Bit Score: 56.88  E-value: 2.83e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134119100   385 LSCKVKQSSanSPEIVGALLDYACSllgstnSSASCDPIAGNGTSGtygqlSFCSPAIKLSYVMSTYYQINPE-DTSCDF 463
Cdd:smart00768   1 LWCVAKPDA--DEAALQAALDYACG------QGADCTAIQPGGSCY-----SPNTVKAHASYAFNSYYQKQGQsSGACDF 67

                           90
                   ....*....|....*
gi 134119100   464 AGNASLSTNRPNTAQ 478
Cdd:smart00768  68 SGTATITTTDPSTGS 82
 
Name Accession Description Interval E-value
Glyco_hydro_72 pfam03198
Glucanosyltransferase; This is a family of glycosylphosphatidylinositol-anchored beta(1-3) ...
 13-338 2.85e-113

Glucanosyltransferase; This is a family of glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferases. The active site residues in the Aspergillus fumigatus example Swiss:B0XT72 are the two glutamate residues at 160 and 261.


Pssm-ID: 397351 [Multi-domain]  Cd Length: 315  Bit Score: 339.74  E-value: 2.85e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134119100   13 FLAMTAALPNITRTG-KYLYDESGNRFYIKGVAYQPegelaassdansanGGFPEPSSFYDPLSSPQNCTRDLPYLQQLG 91
Cdd:pfam03198   2 TSAAFAATPPIEIKGnKFFDSKNGEQFYIKGVDYQP--------------GGSSENSTLVDPLADADVCKRDIPYFKELG 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134119100   92 VNAVRVYSVNSSLNHDDCMKMFNDAGIYVLLDVSLPlNGSIDRSSP--SWSTNLLNEYIETIDAFRSYGNVLGYNIGNEV 169
Cdd:pfam03198  68 INTIRVYAVDPSLNHDECMKALSDAGIYVILDLNTP-KESINRADPagSYNVDYLERYFAVIDAFKNYTNVLGFFAGNEV 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134119100  170 INLVSNTNAAPFVKAAARDIKAYLKSVGSSAL-VGYAAVDgESDFRNSLAEYLTCGGDSIAVDLYGLNNYEWCGNQNINS 248
Cdd:pfam03198 147 TNDASNTDASPYVKAAIRDMKQYISKHKYRTIpVGYSAAD-DADTRVQLADYFACGDDDERADFFGINMYEWCGYSSFKT 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134119100  249 SNWNTITEGFSDLPVATYMSEFGCITSPPRLWTEVAALFASPVSDVFSGGVAFSYFPTSDDYGMVTISDNDTVTVTDDFT 328
Cdd:pfam03198 226 SGYDDRTKEFENYSIPVFFSEYGCNKVTPRPFTEVSALYSSDMTSVFSGGLVYEYSEEANNYGLVSIDGDDVVTTLADFN 305

                         330
                  ....*....|
gi 134119100  329 RLATQYNSTS 338
Cdd:pfam03198 306 NLKSEYAKIS 315
X8 pfam07983
X8 domain; The X8 domain domain contains at least 6 conserved cysteine residues that ...
 385-468 6.62e-19

X8 domain; The X8 domain domain contains at least 6 conserved cysteine residues that presumably form three disulphide bridges. The domain is found in an Olive pollen allergen as well as at the C-terminus of several families of glycosyl hydrolases. This domain may be involved in carbohydrate binding. This domain is characteriztic of GPI-anchored domains.


Pssm-ID: 400371  Cd Length: 76  Bit Score: 81.11  E-value: 6.62e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134119100  385 LSCKVKqSSANSPEIvGALLDYACSLlgstnssASCDPIAGNGTSGTYGQLSFCSPAIKLSYVMSTYYQI-NPEDTSCDF 463
Cdd:pfam07983   1 LWCVAK-DSVDDEDL-QDLFDYACGQ-------ADCSGIQANGTTGKYGCYSPCTVKQHLSYAFNSYYQKqGKASSACDF 71


                  ....*
gi 134119100  464 AGNAS 468
Cdd:pfam07983  72 SGSAT 76
X8 smart00768
Possibly involved in carbohydrate binding; The X8 domain, which may be involved in ...
 385-478 2.83e-10

Possibly involved in carbohydrate binding; The X8 domain, which may be involved in carbohydrate binding, is found in an Olive pollen antigen as well as at the C terminus of family 17 glycosyl hydrolases. It contains 6 conserved cysteine residues which presumably form three disulfide bridges.


Pssm-ID: 197867 [Multi-domain]  Cd Length: 85  Bit Score: 56.88  E-value: 2.83e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134119100   385 LSCKVKQSSanSPEIVGALLDYACSllgstnSSASCDPIAGNGTSGtygqlSFCSPAIKLSYVMSTYYQINPE-DTSCDF 463
Cdd:smart00768   1 LWCVAKPDA--DEAALQAALDYACG------QGADCTAIQPGGSCY-----SPNTVKAHASYAFNSYYQKQGQsSGACDF 67

                           90
                   ....*....|....*
gi 134119100   464 AGNASLSTNRPNTAQ 478
Cdd:smart00768  68 SGTATITTTDPSTGS 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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