second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 417 LGSLFNSPLYSDVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYTDTCCPASVL 496
Cdd:cd18360    1 LGLFFNSPLLADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTDSCCPASIL 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 528513308 497 QAMAILVCAEMYQVKRLQHLCEVCVCAYLQ 526
Cdd:cd18360   81 QAMALLICAEMYQVSRLQHICELYIITQLQ 110

BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical member of the Rho GTPase family of signaling proteins, which is characterized by containing a carboxyl terminal extension that harbors two BTB domains and a BACK domain and is capable of assembling cullin 3-dependent ubiquitin ligase complexes. It is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. RhoBTB3 is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) by facilitating hydroxylation and ubiquitination.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 536 TGISVIRLLRRAKCHNADQLYVWLLHFIANNYLIFSHKPDFLELSDEEREQVERLRWPSRGYLQELSEYQQRRRQiRKSR 615
Cdd:cd18532    1 TSLSVVSLLRKAKFHNADQLSTWLLHFIASNYLIFSQKPEFQDLSAEERDFVETHRWPSSMYLQELAEYRQHIHS-RKSR 79

                 ....
gi 528513308 616 CSIM 619
Cdd:cd18532   80 CSVM 83

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 417 LGSLFNSPLYSDVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYTDTCCPASVL 496
Cdd:cd18360    1 LGLFFNSPLLADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTDSCCPASIL 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 528513308 497 QAMAILVCAEMYQVKRLQHLCEVCVCAYLQ 526
Cdd:cd18360   81 QAMALLICAEMYQVSRLQHICELYIITQLQ 110

BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical member of the Rho GTPase family of signaling proteins, which is characterized by containing a carboxyl terminal extension that harbors two BTB domains and a BACK domain and is capable of assembling cullin 3-dependent ubiquitin ligase complexes. It is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. RhoBTB3 is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) by facilitating hydroxylation and ubiquitination.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 536 TGISVIRLLRRAKCHNADQLYVWLLHFIANNYLIFSHKPDFLELSDEEREQVERLRWPSRGYLQELSEYQQRRRQiRKSR 615
Cdd:cd18532    1 TSLSVVSLLRKAKFHNADQLSTWLLHFIASNYLIFSQKPEFQDLSAEERDFVETHRWPSSMYLQELAEYRQHIHS-RKSR 79

                 ....
gi 528513308 616 CSIM 619
Cdd:cd18532   80 CSVM 83

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308   428 DVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYTDTCCPASVlQAMAILVCAEM 507
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE-NVEELLELADY 79

                           90
                   ....*....|.
gi 528513308   508 YQVKRLQHLCE 518
Cdd:smart00225  80 LQIPGLVELCE 90

RhoBTB protein is an atypical member of the Rho family of small GTPases; Members of the RhoBTB subfamily of Rho GTPases are present in vertebrates, Drosophila, and Dictyostelium. RhoBTB proteins are characterized by a modular organization, consisting of a GTPase domain, a proline rich region, a tandem of two BTB (Broad-Complex, Tramtrack, and Bric a brac) domains, and a C-terminal region of unknown function. RhoBTB proteins may act as docking points for multiple components participating in signal transduction cascades. RhoBTB genes appeared upregulated in some cancer cell lines, suggesting a participation of RhoBTB proteins in the pathogenesis of particular tumors. Note that the Dictyostelium RacA GTPase domain is more closely related to Rac proteins than to RhoBTB proteins, where RacA actually belongs. Thus, the Dictyostelium RacA is not included here. Most Rho proteins contain a lipid modification site at the C-terminus; however, RhoBTB is one of few Rho subfamilies that lack this feature.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308  80 SWDILDSDWVSV-------------RSILEQADIVVIKYSVNDKLAFQQVRNGYAPRLRPLLRHwgVPVILVAVGARLN- 145
Cdd:cd01873   57 SRDVVDGVSVSLrlwdtfgdhdkdrRFAYGRSDVVLLCFSIASPNSLRNVKTMWYPEIRHFCPR--VPVILVGCKLDLRy 134

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 528513308 146 ---DEGPPCTCPLC-ASDWSSCVPHSEGLQLSRDLGATYLELPSLNNFFVGRYF 195
Cdd:cd01873  135 adlDEVNRARRPLArPIKNADILPPETGRAVAKELGIPYYETSVVTQFGVKDVF 188

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 417 LGSLFNSPLYSDVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYTDTCCPASVL 496
Cdd:cd18360    1 LGLFFNSPLLADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTDSCCPASIL 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 528513308 497 QAMAILVCAEMYQVKRLQHLCEVCVCAYLQ 526
Cdd:cd18360   81 QAMALLICAEMYQVSRLQHICELYIITQLQ 110

BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical member of the Rho GTPase family of signaling proteins, which is characterized by containing a carboxyl terminal extension that harbors two BTB domains and a BACK domain and is capable of assembling cullin 3-dependent ubiquitin ligase complexes. It is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. RhoBTB3 is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) by facilitating hydroxylation and ubiquitination.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 536 TGISVIRLLRRAKCHNADQLYVWLLHFIANNYLIFSHKPDFLELSDEEREQVERLRWPSRGYLQELSEYQQRRRQiRKSR 615
Cdd:cd18532    1 TSLSVVSLLRKAKFHNADQLSTWLLHFIASNYLIFSQKPEFQDLSAEERDFVETHRWPSSMYLQELAEYRQHIHS-RKSR 79

                 ....
gi 528513308 616 CSIM 619
Cdd:cd18532   80 CSVM 83

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308  417 LGSLFNSPLYSDVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYTDTCCPASvl 496
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLISEE-- 78

                          90       100
                  ....*....|....*....|..
gi 528513308  497 QAMAILVCAEMYQVKRLQHLCE 518
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCE 100

BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline rich region, a tandem of 2 BTB domains, and a C-terminal BACK domain. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528513308 536 TGISVIRLLRRAKCHNADQLYVWLLHFIANNYLIF-SHKPDFLELSDEEREQVERLRWPSRGYLQELSEYQQRRRQ 610
Cdd:cd18499    1 IDEDVIDLLELAQLHNADQLAAWCLHFISTNYNAFcKHRKEFKLLSPENQEYIEEHRWPPVWYLKELDEYEKKLKE 76

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308   428 DVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYTDTCCPASVlQAMAILVCAEM 507
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE-NVEELLELADY 79

                           90
                   ....*....|.
gi 528513308   508 YQVKRLQHLCE 518
Cdd:smart00225  80 LQIPGLVELCE 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528513308 417 LGSLFNSPLYSDVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYT 487
Cdd:cd18287   13 IGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYT 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 417 LGSLFNSPLYSDVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYTDTccpASVL 496
Cdd:cd18279    9 LGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGK---APNL 85

                         90       100       110
                 ....*....|....*....|....*....|.
gi 528513308 497 QAMA--ILVCAEMYQVKRLQHLCEVCVCAYL 525
Cdd:cd18279   86 DKMAddLLAAADKYALERLKVMCEDALCSNL 116

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 416 TLGSLFNSP----LYSDVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSR-----VVPIHGVSSDTFLAFLEYLY 486
Cdd:cd18296    3 DLDELPFPPeqelSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENngsipVVTLHDVSPEVFAIVLYYIY 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 528513308 487 TDtCCPASVLQAMAILVCAEMYQVKRLQHLCEV 519
Cdd:cd18296   83 TD-DTDLPPENAYDVLYVADMYLLPGLKRLCGT 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 421 FNSPLYSDVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYTDTCCpASVLQAMA 500
Cdd:cd18298    7 FNDPRTSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVD-LPPEDAIG 85

                         90
                 ....*....|....*...
gi 528513308 501 ILVCAEMYQVKRLQHLCE 518
Cdd:cd18298   86 LLDLANSYCEERLKKLCE 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 426 YSDVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYTDtCCPASVLQAMAILVCA 505
Cdd:cd18256   20 FCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTG-VVEVTVSNVQELLVAA 98

                         90       100
                 ....*....|....*....|..
gi 528513308 506 EMYQVKRLQHLCevcvCAYLQS 527
Cdd:cd18256   99 DMLQLTEVVEIC----CEFLKG 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 420 LFNSPLYSDVIFMV--QGSV--LPAHRAVLVARCDVMAAMFSGKYAEARSRVVpIHGVSSDTFLAFLEYLYTD--TCCPA 493
Cdd:cd18282    1 MFNNELMADVHFIVgpPGGTqrIPAHKYVLATGSSVFYAMFYGGLAENKNEIE-IPDVEPAAFLNLLRYLYCDeiDLEPD 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 528513308 494 SVLqamAILVCAEMYQVkrlQHLCEVCVcAYLQ 526
Cdd:cd18282   80 TVL---ATLYAAKKYLV---PHLARACV-QFLE 105

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 417 LGSLF-NSPLYSDVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYTDTCCPASV 495
Cdd:cd18352    3 LGEQYvNNATLSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITND 82

                         90       100
                 ....*....|....*....|...
gi 528513308 496 LqAMAILVCAEMYQVKRLQHLCE 518
Cdd:cd18352   83 I-AKDLLRAADQYLLEGLKRLCE 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 417 LGSLFNSPLYSDVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYTDTccpASVL 496
Cdd:cd18343   12 LGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGK---APNL 88

                         90       100       110
                 ....*....|....*....|....*....|.
gi 528513308 497 QAMA--ILVCAEMYQVKRLQHLCEVCVCAYL 525
Cdd:cd18343   89 DKMAdnLLAAADKYALERLKVMCEEALCNNL 119

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 423 SPLYSDVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSR---VVPIHgvsSDTFLAFLEYLYTDTCCPASVLQAM 499
Cdd:cd18302    3 SDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCsalTMPIP---SDILEIILDYLYTDEASAVKESQNV 79

                         90       100
                 ....*....|....*....|....
gi 528513308 500 A----ILVCAEMYQVKRLQHLCEV 519
Cdd:cd18302   80 EflcnVLVIADQLLITRLKEICEV 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 417 LGSLFNSPLYSDVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYTDTcCPASVL 496
Cdd:cd18344   14 LGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGK-APHLHS 92

                         90       100       110
                 ....*....|....*....|....*....|.
gi 528513308 497 QAMA--ILVCAEMYQVKRLQHLCEVCVCAYL 525
Cdd:cd18344   93 HSMAcdVLAAADKYGLEGLKVLCEDALCRNL 123

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 426 YSDVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYTDTCCPASVLQAMAILVCA 505
Cdd:cd18358   20 FSDVTFKLDDGTINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQLSPTADLDPLELIALA 99

                         90
                 ....*....|...
gi 528513308 506 EMYQVKRLQHLCE 518
Cdd:cd18358  100 NRFCLPHLVALTE 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 417 LGSLFNSPLYSDVIFMVQ-GSVLPAHRAVLVARCDVMAAMF--SGKYAE----ARSRVVPIHGVSSDTFLAFLEYLYTDT 489
Cdd:cd18288    9 FSAMVNNPHLSDVQFQTDsGEVLYAHSFVLYARCPLLIQMVhsEGFSVEeeggVTTRRVLLGDVSGEAARCFLQYLYTAD 88

                         90       100       110
                 ....*....|....*....|....*....|
gi 528513308 490 C-CPASVLQAMAILvcAEMYQVKRLQHLCE 518
Cdd:cd18288   89 TgLPPGLSPHVSEL--ADRFGVSELVHLCE 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 417 LGSLFNSPLYSDVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYTDTcCPASVL 496
Cdd:cd18251   14 LVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYTSE-LELSLD 92

                         90       100       110
                 ....*....|....*....|....*....|.
gi 528513308 497 QAMAILVCAEMYQVKRLQHLCevcvCAYLQS 527
Cdd:cd18251   93 NVQETLTAACQLQIPEVIGFC----CDFLMS 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 417 LGSLFNSPLYSDVIFMV-QGSV---LPAHRAVLVARCDVMAAMFSGKYAEaRSRVVPIHGVSSDTFLAFLEYLYTD--TC 490
Cdd:cd18281   13 FAFLFNNETLSDVHFIVgKGDNeqrIPAHKFVLSIGSAVFDAMFNGGMAT-TSAEIELPDVEPAAFLALLRFLYSDevQI 91

                         90       100
                 ....*....|....*....|....*..
gi 528513308 491 CPASVlqaMAILVCAEMYQVKRLQHLC 517
Cdd:cd18281   92 GPETV---MTTLYTAKKYAVPALESAC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 428 DVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYT-DTCCPASVLQamAILVCAE 506
Cdd:cd18237   23 DVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTaRISVNSNNVQ--SLLDAAN 100

                         90
                 ....*....|.
gi 528513308 507 MYQVKRLQHLC 517
Cdd:cd18237  101 QYQIEPVKKMC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 417 LGSLFNSPLYSDVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYTDTCCpASVL 496
Cdd:cd18253    9 FNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVK-ITTE 87

                         90       100
                 ....*....|....*....|.
gi 528513308 497 QAMAILVCAEMYQVKRLQHLC 517
Cdd:cd18253   88 NVQYLFETSSLFQISPLRDAC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528513308 427 SDVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYT 487
Cdd:cd18234    2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYT 62

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513308 428 DVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYT-----------DTCCPASVL 496
Cdd:cd18255   20 DVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTseltldldciqDVLGAAVHL 99

                         90
                 ....*....|....
gi 528513308 497 QAMAILV-CAEMYQ 509
Cdd:cd18255  100 QMLPVVElCEEFLK 113