NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|66820897|ref|XP_643998|]
View 

hypothetical protein DDB_G0274833 [Dictyostelium discoideum AX4]

Protein Classification

MAPKK1_Int domain-containing protein( domain architecture ID 10556417)

MAPKK1_Int domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MAPKK1_Int pfam08923
Mitogen-activated protein kinase kinase 1 interacting; Mitogen-activated protein kinase kinase ...
 2-129 2.15e-38

Mitogen-activated protein kinase kinase 1 interacting; Mitogen-activated protein kinase kinase 1 interacting protein is a small subcellular adaptor protein required for MAPK signaling and ERK1/2 activation. The overall topology of this domain has a central five-stranded beta-sheet sandwiched between a two alpha-helix and a one alpha-helix layer.


:

Pssm-ID: 462635  Cd Length: 119  Bit Score: 125.92  E-value: 2.15e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66820897     2 EKVDEFLeYIKVSILDKSivdTSLILSDRDGFVLGKIIDKSSsADNVIDNSLISTFSSATDQASKLHAGNNKSIVSFFED 81
Cdd:pfam08923   1 DDVKRFL-YKKLSSVDGL---HAIFITDRDGVPLLKVGDDSS-PDSALRPSFISTFATATDQASKLGLGKNKSIISYYED 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 66820897    82 RIIVHINVSNVILSIITDTESNVGLILGSQDDLIRSLtslsNSIQSDI 129
Cdd:pfam08923  76 YQVVQFNKLPLILSFIASTNCNTGLILSLEQELFPLL----NELKSVV 119
 
Name Accession Description Interval E-value
MAPKK1_Int pfam08923
Mitogen-activated protein kinase kinase 1 interacting; Mitogen-activated protein kinase kinase ...
 2-129 2.15e-38

Mitogen-activated protein kinase kinase 1 interacting; Mitogen-activated protein kinase kinase 1 interacting protein is a small subcellular adaptor protein required for MAPK signaling and ERK1/2 activation. The overall topology of this domain has a central five-stranded beta-sheet sandwiched between a two alpha-helix and a one alpha-helix layer.


Pssm-ID: 462635  Cd Length: 119  Bit Score: 125.92  E-value: 2.15e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66820897     2 EKVDEFLeYIKVSILDKSivdTSLILSDRDGFVLGKIIDKSSsADNVIDNSLISTFSSATDQASKLHAGNNKSIVSFFED 81
Cdd:pfam08923   1 DDVKRFL-YKKLSSVDGL---HAIFITDRDGVPLLKVGDDSS-PDSALRPSFISTFATATDQASKLGLGKNKSIISYYED 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 66820897    82 RIIVHINVSNVILSIITDTESNVGLILGSQDDLIRSLtslsNSIQSDI 129
Cdd:pfam08923  76 YQVVQFNKLPLILSFIASTNCNTGLILSLEQELFPLL----NELKSVV 119
COG2018 COG2018
Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family [Signal ...
 26-108 9.05e-03

Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family [Signal transduction mechanisms];


Pssm-ID: 441621  Cd Length: 123  Bit Score: 33.67  E-value: 9.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66820897  26 ILSDRDGFVlgkiIDKSSSADNVIDNSL---ISTFSSATDQASK-LHAGNNKSIVSFFEDRIIVHINVS-NVILSIITDT 100
Cdd:COG2018  24 VLVSADGLL----IASSLGLDDDDAERLaamAAGLLSLARRAAReLGAGEVEQVVVEGERGYLLVTAAGdGAVLAVLADP 99


                ....*...
gi 66820897 101 ESNVGLIL 108
Cdd:COG2018 100 DADLGLVR 107
 
Name Accession Description Interval E-value
MAPKK1_Int pfam08923
Mitogen-activated protein kinase kinase 1 interacting; Mitogen-activated protein kinase kinase ...
 2-129 2.15e-38

Mitogen-activated protein kinase kinase 1 interacting; Mitogen-activated protein kinase kinase 1 interacting protein is a small subcellular adaptor protein required for MAPK signaling and ERK1/2 activation. The overall topology of this domain has a central five-stranded beta-sheet sandwiched between a two alpha-helix and a one alpha-helix layer.


Pssm-ID: 462635  Cd Length: 119  Bit Score: 125.92  E-value: 2.15e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66820897     2 EKVDEFLeYIKVSILDKSivdTSLILSDRDGFVLGKIIDKSSsADNVIDNSLISTFSSATDQASKLHAGNNKSIVSFFED 81
Cdd:pfam08923   1 DDVKRFL-YKKLSSVDGL---HAIFITDRDGVPLLKVGDDSS-PDSALRPSFISTFATATDQASKLGLGKNKSIISYYED 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 66820897    82 RIIVHINVSNVILSIITDTESNVGLILGSQDDLIRSLtslsNSIQSDI 129
Cdd:pfam08923  76 YQVVQFNKLPLILSFIASTNCNTGLILSLEQELFPLL----NELKSVV 119
COG2018 COG2018
Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family [Signal ...
 26-108 9.05e-03

Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family [Signal transduction mechanisms];


Pssm-ID: 441621  Cd Length: 123  Bit Score: 33.67  E-value: 9.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66820897  26 ILSDRDGFVlgkiIDKSSSADNVIDNSL---ISTFSSATDQASK-LHAGNNKSIVSFFEDRIIVHINVS-NVILSIITDT 100
Cdd:COG2018  24 VLVSADGLL----IASSLGLDDDDAERLaamAAGLLSLARRAAReLGAGEVEQVVVEGERGYLLVTAAGdGAVLAVLADP 99


                ....*...
gi 66820897 101 ESNVGLIL 108
Cdd:COG2018 100 DADLGLVR 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH