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Conserved domains on  [gi|74004857|ref|XP_545521|]
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methionine aminopeptidase 1D, mitochondrial [Canis lupus familiaris]

Protein Classification

methionyl aminopeptidase( domain architecture ID 10099531)

methionyl aminopeptidase catalyzes the hydrolytic removal of N-terminal methionine residues

CATH:  3.90.230.10
EC:  3.4.11.18
Gene Ontology:  GO:0070006|GO:0046872|GO:0006508
PubMed:  7674922

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 94-330 2.38e-127

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


:

Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 363.74  E-value: 2.38e-127
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  94 IQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAYPSPLGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGD 173
Cdd:cd01086   1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857 174 IINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGLQVCPHFVGHG 253
Cdd:cd01086  81 IVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74004857 254 IGSYFHGHPEIWHHA-NDCDLLMEEGMAFTIEPIITEGSPEFQVLEDAWTVVSLDNQRSAQFEHTVLITSEGVQVLTK 330
Cdd:cd01086 161 IGRKFHEEPQIPNYGrPGTGPKLKPGMVFTIEPMINLGTYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILTL 238
 
Name Accession Description Interval E-value
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 94-330 2.38e-127

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 363.74  E-value: 2.38e-127
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  94 IQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAYPSPLGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGD 173
Cdd:cd01086   1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857 174 IINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGLQVCPHFVGHG 253
Cdd:cd01086  81 IVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74004857 254 IGSYFHGHPEIWHHA-NDCDLLMEEGMAFTIEPIITEGSPEFQVLEDAWTVVSLDNQRSAQFEHTVLITSEGVQVLTK 330
Cdd:cd01086 161 IGRKFHEEPQIPNYGrPGTGPKLKPGMVFTIEPMINLGTYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILTL 238
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
86-334 1.11e-115

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 334.67  E-value: 1.11e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  86 IEVKNEDQIQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAYPSPLGYGGFPKSVCTSVNNVLCHGIPD 165
Cdd:COG0024   1 IEIKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857 166 SRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGLQV 245
Cdd:COG0024  81 DRVLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857 246 CPHFVGHGIGSYFHGHPEIWHH-ANDCDLLMEEGMAFTIEPIITEGSPEFQVLEDAWTVVSLDNQRSAQFEHTVLITSEG 324
Cdd:COG0024 161 VREFVGHGIGREMHEEPQVPNYgRPGRGPRLKPGMVLAIEPMINAGTPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTEDG 240

                       250
                ....*....|
gi 74004857 325 VQVLTKLPHE 334
Cdd:COG0024 241 PEILTLPDGG 250
PRK05716 PRK05716
methionine aminopeptidase; Validated
 85-334 2.62e-109

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 318.62  E-value: 2.62e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   85 SIEVKNEDQIQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAYPSPLGYGGFPKSVCTSVNNVLCHGIP 164
Cdd:PRK05716   2 AITIKTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRDQGAIPAPLGYHGFPKSICTSVNEVVCHGIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  165 DSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGLQ 244
Cdd:PRK05716  82 SDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGVGEISPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGFS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  245 VCPHFVGHGIGSYFHGHPEIWHH-ANDCDLLMEEGMAFTIEPIITEGSPEFQVLEDAWTVVSLDNQRSAQFEHTVLITSE 323
Cdd:PRK05716 162 VVREYCGHGIGRKFHEEPQIPHYgAPGDGPVLKEGMVFTIEPMINAGKREVKTLKDGWTVVTKDGSLSAQYEHTVAVTED 241

                        250
                 ....*....|.
gi 74004857  324 GVQVLTKLPHE 334
Cdd:PRK05716 242 GPEILTLRPEE 252
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 86-331 5.08e-91

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 271.91  E-value: 5.08e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857    86 IEVKNEDQIQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAYPSPLGYGGFPKSVCTSVNNVLCHGIPD 165
Cdd:TIGR00500   1 ISLKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHGAKPAFLGYYGFPGSVCISVNEVVIHGIPD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   166 SRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGLQV 245
Cdd:TIGR00500  81 KKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGFSV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   246 CPHFVGHGIGSYFHGHPEIWHHANDCD-LLMEEGMAFTIEPIITEGSPEFQVLEDAWTVVSLDNQRSAQFEHTVLITSEG 324
Cdd:TIGR00500 161 VREYCGHGIGRKFHEEPQIPNYGKKFTnVRLKEGMVFTIEPMVNTGTEEITTAADGWTVKTKDGSLSAQFEHTIVITDNG 240


                  ....*..
gi 74004857   325 VQVLTKL 331
Cdd:TIGR00500 241 PEILTER 247
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 95-321 8.76e-55

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 177.82  E-value: 8.76e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857    95 QGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAYpsplGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGDI 174
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGA----RGPAFPPIVASGPNAAIPHYIPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   175 INIDVTVYYN-GYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGL-QVCPHFVGH 252
Cdd:pfam00557  77 VLIDVGAEYDgGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLgEYFPHGLGH 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74004857   253 GIGSYFHGHPEIWHhaNDCDLLMEEGMAFTIEPIITEgspefqvledawtvvsLDNQRSAQFEHTVLIT 321
Cdd:pfam00557 157 GIGLEVHEGPYISR--GGDDRVLEPGMVFTIEPGIYF----------------IPGWGGVRIEDTVLVT 207
 
Name Accession Description Interval E-value
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 94-330 2.38e-127

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 363.74  E-value: 2.38e-127
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  94 IQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAYPSPLGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGD 173
Cdd:cd01086   1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857 174 IINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGLQVCPHFVGHG 253
Cdd:cd01086  81 IVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74004857 254 IGSYFHGHPEIWHHA-NDCDLLMEEGMAFTIEPIITEGSPEFQVLEDAWTVVSLDNQRSAQFEHTVLITSEGVQVLTK 330
Cdd:cd01086 161 IGRKFHEEPQIPNYGrPGTGPKLKPGMVFTIEPMINLGTYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILTL 238
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
86-334 1.11e-115

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 334.67  E-value: 1.11e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  86 IEVKNEDQIQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAYPSPLGYGGFPKSVCTSVNNVLCHGIPD 165
Cdd:COG0024   1 IEIKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857 166 SRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGLQV 245
Cdd:COG0024  81 DRVLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857 246 CPHFVGHGIGSYFHGHPEIWHH-ANDCDLLMEEGMAFTIEPIITEGSPEFQVLEDAWTVVSLDNQRSAQFEHTVLITSEG 324
Cdd:COG0024 161 VREFVGHGIGREMHEEPQVPNYgRPGRGPRLKPGMVLAIEPMINAGTPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTEDG 240

                       250
                ....*....|
gi 74004857 325 VQVLTKLPHE 334
Cdd:COG0024 241 PEILTLPDGG 250
PRK05716 PRK05716
methionine aminopeptidase; Validated
 85-334 2.62e-109

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 318.62  E-value: 2.62e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   85 SIEVKNEDQIQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAYPSPLGYGGFPKSVCTSVNNVLCHGIP 164
Cdd:PRK05716   2 AITIKTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRDQGAIPAPLGYHGFPKSICTSVNEVVCHGIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  165 DSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGLQ 244
Cdd:PRK05716  82 SDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGVGEISPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGFS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  245 VCPHFVGHGIGSYFHGHPEIWHH-ANDCDLLMEEGMAFTIEPIITEGSPEFQVLEDAWTVVSLDNQRSAQFEHTVLITSE 323
Cdd:PRK05716 162 VVREYCGHGIGRKFHEEPQIPHYgAPGDGPVLKEGMVFTIEPMINAGKREVKTLKDGWTVVTKDGSLSAQYEHTVAVTED 241

                        250
                 ....*....|.
gi 74004857  324 GVQVLTKLPHE 334
Cdd:PRK05716 242 GPEILTLRPEE 252
PLN03158 PLN03158
methionine aminopeptidase; Provisional
 55-332 6.44e-109

methionine aminopeptidase; Provisional


Pssm-ID: 215607 [Multi-domain]  Cd Length: 396  Bit Score: 322.94  E-value: 6.44e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   55 PAAVSSAHPVPEHIKKPDYVTTGI-----VPDWGDSIEVKNEDQIQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVH 129
Cdd:PLN03158  99 PYPISPRRVVPDHIPKPDWALDGTpkiepNSDLQHSVEIKTPEQIQRMRETCRIAREVLDAAARAIKPGVTTDEIDRVVH 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  130 QEIIRHDAYPSPLGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEV 209
Cdd:PLN03158 179 EATIAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPDARKLEDGDIVNVDVTVYYKGCHGDLNETFFVGNVDEASRQLVKC 258

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  210 ARRCRDEAIAACRAGAPFSVIGNTISHITHQNGLQVCPHFVGHGIGSYFHGHPEIWHHA-NDCDLLMEEGMAFTIEPIIT 288
Cdd:PLN03158 259 TYECLEKAIAIVKPGVRYREVGEVINRHATMSGLSVVKSYCGHGIGELFHCAPNIPHYArNKAVGVMKAGQVFTIEPMIN 338

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 74004857  289 EGSPEFQVLEDAWTVVSLDNQRSAQFEHTVLITSEGVQVLT-KLP 332
Cdd:PLN03158 339 AGVWRDRMWPDGWTAVTADGKRSAQFEHTLLVTETGVEVLTaRLP 383
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 83-329 1.99e-97

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 288.66  E-value: 1.99e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   83 GDSIEVKNEDQIQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAYPSPLGYGGFPKSVCTSVNNVLCHG 162
Cdd:PRK12896   5 GRGMEIKSPRELEKMRKIGRIVATALKEMGKAVEPGMTTKELDRIAEKRLEEHGAIPSPEGYYGFPGSTCISVNEEVAHG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  163 IPDSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNG 242
Cdd:PRK12896  85 IPGPRVIKDGDLVNIDVSAYLDGYHGDTGITFAVGPVSEEAEKLCRVAEEALWAGIKQVKAGRPLNDIGRAIEDFAKKNG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  243 LQVCPHFVGHGIGSYFHGHP-EIWHHANDCD-LLMEEGMAFTIEPIITEGSPEFQVLEDAWTVVSLDNQRSAQFEHTVLI 320
Cdd:PRK12896 165 YSVVRDLTGHGVGRSLHEEPsVILTYTDPLPnRLLRPGMTLAVEPFLNLGAKDAETLDDGWTVVTPDKSLSAQFEHTVVV 244


                 ....*....
gi 74004857  321 TSEGVQVLT 329
Cdd:PRK12896 245 TRDGPEILT 253
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 86-331 5.08e-91

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 271.91  E-value: 5.08e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857    86 IEVKNEDQIQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAYPSPLGYGGFPKSVCTSVNNVLCHGIPD 165
Cdd:TIGR00500   1 ISLKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHGAKPAFLGYYGFPGSVCISVNEVVIHGIPD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   166 SRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGLQV 245
Cdd:TIGR00500  81 KKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGFSV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   246 CPHFVGHGIGSYFHGHPEIWHHANDCD-LLMEEGMAFTIEPIITEGSPEFQVLEDAWTVVSLDNQRSAQFEHTVLITSEG 324
Cdd:TIGR00500 161 VREYCGHGIGRKFHEEPQIPNYGKKFTnVRLKEGMVFTIEPMVNTGTEEITTAADGWTVKTKDGSLSAQFEHTIVITDNG 240


                  ....*..
gi 74004857   325 VQVLTKL 331
Cdd:TIGR00500 241 PEILTER 247
PRK12318 PRK12318
methionyl aminopeptidase;
86-331 1.17e-79

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 244.73  E-value: 1.17e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   86 IEVKNEDQIQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAYPSPLGYGG--FPKSVCTSVNNVLCHGI 163
Cdd:PRK12318  41 IIIKTPEQIEKIRKACQVTARILDALCEAAKEGVTTNELDELSRELHKEYNAIPAPLNYGSppFPKTICTSLNEVICHGI 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  164 PDSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGL 243
Cdd:PRK12318 121 PNDIPLKNGDIMNIDVSCIVDGYYGDCSRMVMIGEVSEIKKKVCQASLECLNAAIAILKPGIPLYEIGEVIENCADKYGF 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  244 QVCPHFVGHGIGSYFHGHPEIWHHANDCDLLMEEGMAFTIEPIITEGSPE-FQVLEDAWTVVSLDNQRSAQFEHTVLITS 322
Cdd:PRK12318 201 SVVDQFVGHGVGIKFHENPYVPHHRNSSKIPLAPGMIFTIEPMINVGKKEgVIDPINHWEARTCDNQPSAQWEHTILITE 280


                 ....*....
gi 74004857  323 EGVQVLTKL 331
Cdd:PRK12318 281 TGYEILTLL 289
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 95-321 8.76e-55

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 177.82  E-value: 8.76e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857    95 QGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAYpsplGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGDI 174
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGA----RGPAFPPIVASGPNAAIPHYIPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   175 INIDVTVYYN-GYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGL-QVCPHFVGH 252
Cdd:pfam00557  77 VLIDVGAEYDgGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLgEYFPHGLGH 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74004857   253 GIGSYFHGHPEIWHhaNDCDLLMEEGMAFTIEPIITEgspefqvledawtvvsLDNQRSAQFEHTVLIT 321
Cdd:pfam00557 157 GIGLEVHEGPYISR--GGDDRVLEPGMVFTIEPGIYF----------------IPGWGGVRIEDTVLVT 207
PRK12897 PRK12897
type I methionyl aminopeptidase;
86-331 1.18e-48

type I methionyl aminopeptidase;


Pssm-ID: 171806  Cd Length: 248  Bit Score: 163.67  E-value: 1.18e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   86 IEVKNEDQIQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAYPSPLGYGGFPKSVCTSVNNVLCHGIPD 165
Cdd:PRK12897   2 ITIKTKNEIDLMHESGKLLASCHREIAKIMKPGITTKEINTFVEAYLEKHGATSEQKGYNGYPYAICASVNDEMCHAFPA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  166 SRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGLQV 245
Cdd:PRK12897  82 DVPLTEGDIVTIDMVVNLNGGLSDSAWTYRVGKVSDEAEKLLLVAENALYKGIDQAVIGNRVGDIGYAIESYVANEGFSV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  246 CPHFVGHGIGSYFHGHPEIWHHANDCD-LLMEEGMAFTIEPIITEGSPEFQVLEDAWTVVSLDNQRSAQFEHTVLITSEG 324
Cdd:PRK12897 162 ARDFTGHGIGKEIHEEPAIFHFGKQGQgPELQEGMVITIEPIVNVGMRYSKVDLNGWTARTMDGKLSAQYEHTIAITKDG 241


                 ....*..
gi 74004857  325 VQVLTKL 331
Cdd:PRK12897 242 PIILTKL 248
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 94-324 3.68e-40

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 140.28  E-value: 3.68e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  94 IQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAYPSPlgyggfpkSVCTSVNNV--LCHGIPDSRPLQD 171
Cdd:cd01066   1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGGYPAG--------PTIVGSGARtaLPHYRPDDRRLQE 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857 172 GDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGL-QVCPHFV 250
Cdd:cd01066  73 GDLVLVDLGGVYDGYHADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLgPNFGHRT 152

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74004857 251 GHGIGSYFHGHPEIWHHANDcdlLMEEGMAFTIEPIItegspefqvledawtvvSLDNQRSAQFEHTVLITSEG 324
Cdd:cd01066 153 GHGIGLEIHEPPVLKAGDDT---VLEPGMVFAVEPGL-----------------YLPGGGGVRIEDTVLVTEDG 206
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
88-334 9.83e-40

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 141.50  E-value: 9.83e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  88 VKNEDQIQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAYpsplgYGGFPKSVCTSVNNVLCHGIPDSR 167
Cdd:COG0006  73 IKSPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRRGAE-----GPSFDTIVASGENAAIPHYTPTDR 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857 168 PLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGLQVC- 246
Cdd:COG0006 148 PLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYGEYf 227

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857 247 PHFVGHGIGSYFHGHPEIwhhANDCDLLMEEGMAFTIEPIITegspefqvLEDAWTVvsldnqRSaqfEHTVLITSEGVQ 326
Cdd:COG0006 228 PHGTGHGVGLDVHEGPQI---SPGNDRPLEPGMVFTIEPGIY--------IPGIGGV------RI---EDTVLVTEDGAE 287


                ....*...
gi 74004857 327 VLTKLPHE 334
Cdd:COG0006 288 VLTRLPRE 295
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 94-287 2.43e-27

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 106.44  E-value: 2.43e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  94 IQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAY-PSplgyggFPKSVCTSVNNVLCHGIPDSRPLQDG 172
Cdd:cd01092   1 IELLRKAARIADKAFEELLEFIKPGMTEREVAAELEYFMRKLGAEgPS------FDTIVASGPNSALPHGVPSDRKIEEG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857 173 DIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTI-SHITHQNGLQVCPHFVG 251
Cdd:cd01092  75 DLVLIDFGAIYDGYCSDITRTVAVGEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDKAArDVIEEAGYGEYFIHRTG 154

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 74004857 252 HGIGSYFHGHPEIwhhANDCDLLMEEGMAFTIEPII 287
Cdd:cd01092 155 HGVGLEVHEAPYI---SPGSDDVLEEGMVFTIEPGI 187
PRK07281 PRK07281
methionyl aminopeptidase;
117-329 3.97e-22

methionyl aminopeptidase;


Pssm-ID: 180918  Cd Length: 286  Bit Score: 94.14  E-value: 3.97e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  117 VDMTteEIDALVHQEIIRHDAYPSPLGYGG----FPKSVCTSVNNVLCHGIPDSRPLQDGDIINIDV------------- 179
Cdd:PRK07281  35 VDMW--EVEEYVRRRCKEENVLPLQIGVDGammdYPYATCCGLNDEVAHAFPRHYILKEGDLLKVDMvlsepldksivdv 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  180 --------------TVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGLQV 245
Cdd:PRK07281 113 sklnfdnveqmkkyTESYRGGLADSCWAYAVGTPSDEVKNLMDVTKEAMYRGIEQAVVGNRIGDIGAAIQEYAESRGYGV 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  246 CPHFVGHGIGSYFHGHPEIWHHANDC-DLLMEEGMAFTIEPIITEGSPEFQV-LEDAWTVVSLDNQRSAQFEHTVLITSE 323
Cdd:PRK07281 193 VRDLVGHGVGPTMHEEPMVPNYGTAGrGLRLREGMVLTIEPMINTGTWEIDTdMKTGWAHKTLDGGLSCQYEHQFVITKD 272


                 ....*.
gi 74004857  324 GVQVLT 329
Cdd:PRK07281 273 GPVILT 278
met_pdase_II TIGR00501
methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. ...
 99-290 1.16e-17

methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. The role of this protein in general is to produce the mature amino end of cytosolic proteins by removing the N-terminal methionine. This model describes type II, among which the eukaryotic members typically have an N-terminal extension not present in archaeal members. It can act cotranslationally. The enzyme from rat has been shown to associate with translation initiation factor 2 (IF-2) and may have a role in translational regulation. [Protein fate, Protein modification and repair]


Pssm-ID: 129592  Cd Length: 295  Bit Score: 81.76  E-value: 1.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857    99 QACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAYPsplgygGFPKSVctSVNNVLCHGIP---DSRPLQDGDII 175
Cdd:TIGR00501  10 EAGKIHSKVRREAADRIVPGVKLLEVAEFVENRIRELGAEP------AFPCNI--SINECAAHFTPkagDKTVFKDGDVV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   176 NIDVTVYYNGYHGDTSETFLVGNVdecGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGLQVCPHFVGHGIG 255
Cdd:TIGR00501  82 KLDLGAHVDGYIADTAITVDLGDQ---YDNLVKAAKDALYTAIKEIRAGVRVGEIGKAIQEVIESYGVKPISNLTGHSMA 158

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 74004857   256 SY-FHGHPEIWHHANDCDLLMEEGMAFTIEPIITEG 290
Cdd:TIGR00501 159 PYrLHGGKSIPNVKERDTTKLEEGDVVAIEPFATDG 194
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 94-290 7.78e-17

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 79.22  E-value: 7.78e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  94 IQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAYPsplgygGFPKSVctSVNNVLCHGIP---DSRPLQ 170
Cdd:cd01088   1 LEKYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGAGP------AFPVNL--SINECAAHYTPnagDDTVLK 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857 171 DGDIINIDVTVYYNGYHGDTSETFLVGNVdecGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGLQVCPHFV 250
Cdd:cd01088  73 EGDVVKLDFGAHVDGYIADSAFTVDFDPK---YDDLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGFKPIRNLT 149

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 74004857 251 GHGIGSY-FHGHPEIWHHANDCDLLMEEGMAFTIEPIITEG 290
Cdd:cd01088 150 GHSIERYrLHAGKSIPNVKGGEGTRLEEGDVYAIEPFATTG 190
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 94-330 3.97e-15

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 73.76  E-value: 3.97e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  94 IQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAypsPLGYGgfPKSVCTSVNNVLcHGIPDSRPLQDGD 173
Cdd:cd01087   1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGA---RLAYS--YIVAAGSNAAIL-HYVHNDQPLKDGD 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857 174 IINIDVTVYYNGYHGDTSETFLV-GNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIgNTISHITHQNGLQV------- 245
Cdd:cd01087  75 LVLIDAGAEYGGYASDITRTFPVnGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDI-HLLAHRVLAEGLKElgilkgd 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857 246 -------------CPHFVGHGIGSYFH--GHPeiwHHANDCDLLMEEGMAFTIEP---IItegsPEFQVLEDAWTVVSL- 306
Cdd:cd01087 154 vdeivesgayakfFPHGLGHYLGLDVHdvGGY---LRYLRRARPLEPGMVITIEPgiyFI----PDLLDVPEYFRGGGIr 226

                       250       260
                ....*....|....*....|....*.
gi 74004857 307 --DNqrsaqfehtVLITSEGVQVLTK 330
Cdd:cd01087 227 ieDD---------VLVTEDGPENLTR 243
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 63-299 3.10e-09

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 57.80  E-value: 3.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   63 PVPEHIKKPDYVTTGIVPDWGDSIEVKNEDQIQGLRQACQLARHV------LLLAGKSLkVDMtTEEIDALVhQEIIRHD 136
Cdd:PTZ00053 127 PVGEIQEYPGENSSRTSSEEKRELEKLSEEQYQDLRRAAEVHRQVrryaqsVIKPGVKL-IDI-CERIESKS-RELIEAD 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  137 AypspLGYG-GFPKSVctSVNNVLCHGIP---DSRPLQDGDIINIDVTVYYNGYHGDTSET--FlvgnvDECGKKLVEVA 210
Cdd:PTZ00053 204 G----LKCGwAFPTGC--SLNHCAAHYTPntgDKTVLTYDDVCKLDFGTHVNGRIIDCAFTvaF-----NPKYDPLLQAT 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  211 RRCRDEAIAACRAGAPFSVIGNTI-----SHITHQNGlQVCP-----HFVGHGIGSY-FHGHPEIWHHANDCDLLMEEGM 279
Cdd:PTZ00053 273 KDATNTGIKEAGIDVRLSDIGAAIqevieSYEVEIKG-KTYPiksirNLNGHSIGPYiIHGGKSVPIVKGGENTRMEEGE 351

                        250       260
                 ....*....|....*....|
gi 74004857  280 AFTIEPIITEGSPefQVLED 299
Cdd:PTZ00053 352 LFAIETFASTGRG--YVNED 369
PRK09795 PRK09795
aminopeptidase; Provisional
 87-334 3.61e-09

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 57.25  E-value: 3.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   87 EVKNEDQIQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDAYPSplgygGFPKSVCTSVNNVLCHGIPDS 166
Cdd:PRK09795 126 QIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKA-----SFDTIVASGWRGALPHGKASD 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  167 RPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKK-----LVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQN 241
Cdd:PRK09795 201 KIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAEShplfnVYQIVLQAQLAAISAIRPGVRCQQVDDAARRVITEA 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  242 GL-QVCPHFVGHGIGSYFHGHPEIwhhANDCDLLMEEGMAFTIEPIITegspefqvledawtvvsLDNQRSAQFEHTVLI 320
Cdd:PRK09795 281 GYgDYFGHNTGHAIGIEVHEDPRF---SPRDTTTLQPGMLLTVEPGIY-----------------LPGQGGVRIEDVVLV 340

                        250
                 ....*....|....
gi 74004857  321 TSEGVQVLTKLPHE 334
Cdd:PRK09795 341 TPQGAEVLYAMPKT 354
PRK15173 PRK15173
peptidase; Provisional
 88-334 4.56e-09

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 57.03  E-value: 4.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   88 VKNEDQIQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHdaypSPLGYGGFPK-SVCTSVNNVLchgIPDS 166
Cdd:PRK15173  95 IKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSK----SETHFSRFHLiSVGADFSPKL---IPSN 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  167 RPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGLqvc 246
Cdd:PRK15173 168 TKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTMEVIKKSGL--- 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  247 PHF----VGHGIGSY--FHGHPEIWHHANDCdllMEEGMAFTIEpiitegSPEFQVledawtvvsldNQRSAQFEHTVLI 320
Cdd:PRK15173 245 PNYnrghLGHGNGVFlgLEESPFVSTHATES---FTSGMVLSLE------TPYYGY-----------NLGSIMIEDMILI 304

                        250
                 ....*....|....
gi 74004857  321 TSEGVQVLTKLPHE 334
Cdd:PRK15173 305 NKEGIEFLSKLPRD 318
PRK14575 PRK14575
putative peptidase; Provisional
 88-334 9.59e-09

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 56.25  E-value: 9.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   88 VKNEDQIQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHdaypSPLGYGGFPK-SVCTSVNNVLchgIPDS 166
Cdd:PRK14575 178 IKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSK----SETHFSRFHLiSVGADFSPKL---IPSN 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  167 RPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGLqvc 246
Cdd:PRK14575 251 TKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTMEVIKKSGL--- 327

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  247 PHF----VGHGIGSY--FHGHPEIWHHANDCdllMEEGMAFTIEpiitegSPEFQVledawtvvsldNQRSAQFEHTVLI 320
Cdd:PRK14575 328 PNYnrghLGHGNGVFlgLEESPFVSTHATES---FTSGMVLSLE------TPYYGY-----------NLGSIMIEDMILI 387

                        250
                 ....*....|....
gi 74004857  321 TSEGVQVLTKLPHE 334
Cdd:PRK14575 388 NKEGIEFLSKLPRD 401
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 147-329 1.80e-08

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 54.26  E-value: 1.80e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857 147 FPksVCTSVNNVLCHGIP----DSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGK--KLVEVARRCRDEAIAA 220
Cdd:cd01089  59 FP--TCISVNNCVCHFSPlksdATYTLKDGDVVKIDLGCHIDGYIAVVAHTIVVGAEAETPVtgKKADVIAAAHYALEAA 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857 221 CRAGAPfsviGNTISHIThQNGLQVCPHFVGHGI-GSYFHghpeiwhhandcdlLMEEGMAFtiepiiTEGSPEFQVLED 299
Cdd:cd01089 137 LRLLRP----GNQNSDIT-EAIQKVIVDYGCTPVeGVLSH--------------QLKRVVSS------GEGKAKLVECVK 191

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 74004857 300 -----AWTVV-SLDNQRSAQFEHTVLITSEGVQVLT 329
Cdd:cd01089 192 hgllfPYPVLyEKEGEVVAQFKLTVLLTPNGVTVLT 227
PRK14576 PRK14576
putative endopeptidase; Provisional
 88-331 8.18e-08

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 53.48  E-value: 8.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   88 VKNEDQIQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIrhdAYPSPlgygGFPKSVCTSV-NNVLCHGIPDS 166
Cdd:PRK14576 177 IKSPWEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTAAFKAAVM---SFPET----NFSRFNLISVgDNFSPKIIADT 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  167 RPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGLqvc 246
Cdd:PRK14576 250 TPAKVGDLIKFDCGIDVAGYGADLARTFVLGEPDKLTQQIYDTIRTGHEHMLSMVAPGVKLKAVFDSTMAVIKTSGL--- 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  247 PHF----VGHGIGsYFHGHPEIWHHANDCDLLMEEGMAFTIEpiitegSPEFQVledawtvvsldNQRSAQFEHTVLITS 322
Cdd:PRK14576 327 PHYnrghLGHGDG-VFLGLEEVPFVSTQATETFCPGMVLSLE------TPYYGI-----------GVGSIMLEDMILITD 388


                 ....*....
gi 74004857  323 EGVQVLTKL 331
Cdd:PRK14576 389 SGFEFLSKL 397
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 89-285 6.00e-07

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 50.88  E-value: 6.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   89 KNEDQIQGLRQACQLARHVLLLAGKSLKVDMTTEEIDALVHQEIIRHDA-YPSplgyggFPKSVCTSVNNVLCHGIPDSR 167
Cdd:PRK10879 174 KSPEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEIHHEFNRHGArYPS------YNTIVGSGENGCILHYTENES 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857  168 PLQDGDIINIDVTVYYNGYHGDTSETFLVGNvdecgkKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQ------N 241
Cdd:PRK10879 248 EMRDGDLVLIDAGCEYKGYAGDITRTFPVNG------KFTPAQREIYDIVLESLETSLRLYRPGTSIREVTGEvvrimvS 321

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74004857  242 GL--------------------QVCPHFVGHGIGSYFHghpEIWHHANDCDLLMEEGMAFTIEP 285
Cdd:PRK10879 322 GLvklgilkgdvdqliaenahrPFFMHGLSHWLGLDVH---DVGVYGQDRSRILEPGMVLTVEP 382
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 147-242 7.34e-05

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 44.11  E-value: 7.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857   147 FPksVCTSVNNVLCHGIP----DSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDE---CGKK--LVEVARRCRDEA 217
Cdd:TIGR00495  78 FP--TCISVNNCVGHFSPlksdQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEepvTGRKadVIAAAHLAAEAA 155

                          90       100
                  ....*....|....*....|....*
gi 74004857   218 IAACRAGAPFSVIGNTISHITHQNG 242
Cdd:TIGR00495 156 LRLVKPGNTNTQVTEAINKVAHSYG 180
Creatinase cd01090
Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea.
 161-292 2.81e-03

Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea.


Pssm-ID: 238523 [Multi-domain]  Cd Length: 228  Bit Score: 38.67  E-value: 2.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74004857 161 HGIPDSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQ 240
Cdd:cd01090  69 HNPVTNRKVQRGDILSLNCFPMIAGYYTALERTLFLDEVSDAHLKIWEANVAVHERGLELIKPGARCKDIAAELNEMYRE 148

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 74004857 241 NGLQVCPHF-VGHGIG--SYFHGHPEIWHHANDCDLLMEEGMAFTIEPIIT--EGSP 292
Cdd:cd01090 149 HDLLRYRTFgYGHSFGvlSHYYGREAGLELREDIDTVLEPGMVVSMEPMIMlpEGQP 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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