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Conserved domains on  [gi|50294418|ref|XP_449620|]
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uncharacterized protein GVI51_M06237 [Nakaseomyces glabratus]

Protein Classification

MFS transporter( domain architecture ID 13023297)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 82-537 2.30e-89

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 279.46  E-value: 2.30e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  82 FLIVIYNGFLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINIL 161
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 162 LASVPkKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLIlLDNNNWRWLFGF 241
Cdd:cd17323  81 CALAP-NIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFI-TQSLGWRWIFWF 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 242 LCIVSGLGLIMVILLLpetlrcivgngdrqwenwsqnendmstqpvdfsspisrwsfvsdigflnpitqdsifkglyphp 321
Cdd:cd17323 159 LAIISGFCLILIFLFL---------------------------------------------------------------- 174

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 322 pkfsvwtylrimtfPPVILTSIANALLFCTYYSISVTLSHFLATEYSYSNLKIGACYVCPGVCMLLGSQIGGHLSDSMRK 401
Cdd:cd17323 175 --------------PIVLLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYR 240

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 402 SWKKENYNTEYPlEFRLILTVCGVLLAIGGSIGYGWCIQFHYHISAVLVFAGLMAFGLTWCNNTIMTYLSELLSLRVSSA 481
Cdd:cd17323 241 RLKKKNGGKPEP-EARLPPAFIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASA 319

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 50294418 482 IAVSSFFRNIAAAISSALIAKLCQKMGIGFCFLGLGLINLVSLFSILVLINNRNKW 537
Cdd:cd17323 320 LAANTLVRSIFAAIFPLFAQPMFNNLGVGWAFTLLAFISLAMIPIPFIFYKYGKKI 375
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 82-537 2.30e-89

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 279.46  E-value: 2.30e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  82 FLIVIYNGFLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINIL 161
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 162 LASVPkKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLIlLDNNNWRWLFGF 241
Cdd:cd17323  81 CALAP-NIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFI-TQSLGWRWIFWF 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 242 LCIVSGLGLIMVILLLpetlrcivgngdrqwenwsqnendmstqpvdfsspisrwsfvsdigflnpitqdsifkglyphp 321
Cdd:cd17323 159 LAIISGFCLILIFLFL---------------------------------------------------------------- 174

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 322 pkfsvwtylrimtfPPVILTSIANALLFCTYYSISVTLSHFLATEYSYSNLKIGACYVCPGVCMLLGSQIGGHLSDSMRK 401
Cdd:cd17323 175 --------------PIVLLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYR 240

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 402 SWKKENYNTEYPlEFRLILTVCGVLLAIGGSIGYGWCIQFHYHISAVLVFAGLMAFGLTWCNNTIMTYLSELLSLRVSSA 481
Cdd:cd17323 241 RLKKKNGGKPEP-EARLPPAFIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASA 319

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 50294418 482 IAVSSFFRNIAAAISSALIAKLCQKMGIGFCFLGLGLINLVSLFSILVLINNRNKW 537
Cdd:cd17323 320 LAANTLVRSIFAAIFPLFAQPMFNNLGVGWAFTLLAFISLAMIPIPFIFYKYGKKI 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
74-490 1.66e-41

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 152.44  E-value: 1.66e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  74 TSFQVSLIFLIVIYNGFLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISIS 153
Cdd:COG2814   4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 154 LMVIINILLASVPkKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLiLLDNN 233
Cdd:COG2814  84 LFALGSLLCALAP-SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL-LADLF 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 234 NWRWLFGFLCIVSGLGLIMVILLLPETLrcivgngdrqwenwsqnendmstqpvdfsspisrwsfvsdigflnpitqdsi 313
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESR---------------------------------------------------- 189

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 314 fkglyPHPPKFSVWTYLRIMTFPPVILTSIANALLFCTYYSISVTLSHFLATEYSYSNLKIGACYVCPGVCMLLGSQIGG 393
Cdd:COG2814 190 -----PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAG 264

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 394 HLSDSMRKswkkenynteyplefRLILTVCGVLLAIGgsigyGWCIQFHYHISAVLVFAGLMAFGLTWCNNTIMTYLSEL 473
Cdd:COG2814 265 RLADRFGR---------------RRLLLIGLLLLALG-----LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324

                       410
                ....*....|....*...
gi 50294418 474 LSLRV-SSAIAVSSFFRN 490
Cdd:COG2814 325 APPEArGRASGLYNSAFF 342
2_A_01_02 TIGR00880
Multidrug resistance protein;
122-260 2.26e-27

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 107.35  E-value: 2.26e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   122 SVFMATFSISPLFW----GALADKGGRKILYIISISLMVIINILLAsVPKKIGSLIFLRIIQAFASSSVISLGAGTVADL 197
Cdd:TIGR00880   1 GLLLAGYALGQLIYsplsGLLTDRFGRKPVLLVGLFIFVLSTAMFA-LSSNITVLIIARFLQGFGAAFALVAGAALIADI 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 50294418   198 TPPKDRGKAMAYFMLGPNLGPILAPIIaGLILLDNNNWRWLFGFLCIVSGLGLIMVILLLPET 260
Cdd:TIGR00880  80 YPPEERGVALGLMSAGIALGPLLGPPL-GGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_1 pfam07690
Major Facilitator Superfamily;
89-488 5.06e-26

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 109.04  E-value: 5.06e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418    89 GFLGPLAGNVFIPALPL-LQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPK 167
Cdd:pfam07690   5 AFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   168 kIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLiLLDNNNWRWLFGFLCIVSG 247
Cdd:pfam07690  85 -LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGL-LASLFGWRAAFLILAILSL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   248 LGLIMVILLLPETLRcivgngdrqwenwsqnendmstqpvdfsspisrwsfvsdigflnpitqdsifKGLYPHPPKFSVW 327
Cdd:pfam07690 163 LAAVLLLLPRPPPES----------------------------------------------------KRPKPAEEARLSL 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   328 TYLRIMTFPPVILTSIANALLFCTYYSISVTLSHFLATEYSYSNLKIGACYVCPGVCMLLGSQIGGHLSDSMRKswkken 407
Cdd:pfam07690 191 IVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGR------ 264

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   408 ynteyplEFRLILTVCGVLLAIGGSIGYGWCIQFHYHISAVLVFAGLMAFGLTWCNNTIMTYLSELLSLRVSSAIAVSSF 487
Cdd:pfam07690 265 -------RRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGS 337


                  .
gi 50294418   488 F 488
Cdd:pfam07690 338 L 338
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
91-261 3.04e-21

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 95.75  E-value: 3.04e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   91 LGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVpKKIG 170
Cdd:PRK11102   2 LMPLAIDMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALA-QTID 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  171 SLIFLRIIQAF--ASSSVIsLGAgTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLdNNNWRWLFGFLCIVSGL 248
Cdd:PRK11102  81 QLIYMRFLHGLaaAAASVV-INA-LMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLV-WFSWHAIFWVLALAAIL 157

                        170
                 ....*....|...
gi 50294418  249 GLIMVILLLPETL 261
Cdd:PRK11102 158 AAALVFFFIPETL 170
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 82-537 2.30e-89

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 279.46  E-value: 2.30e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  82 FLIVIYNGFLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINIL 161
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 162 LASVPkKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLIlLDNNNWRWLFGF 241
Cdd:cd17323  81 CALAP-NIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFI-TQSLGWRWIFWF 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 242 LCIVSGLGLIMVILLLpetlrcivgngdrqwenwsqnendmstqpvdfsspisrwsfvsdigflnpitqdsifkglyphp 321
Cdd:cd17323 159 LAIISGFCLILIFLFL---------------------------------------------------------------- 174

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 322 pkfsvwtylrimtfPPVILTSIANALLFCTYYSISVTLSHFLATEYSYSNLKIGACYVCPGVCMLLGSQIGGHLSDSMRK 401
Cdd:cd17323 175 --------------PIVLLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYR 240

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 402 SWKKENYNTEYPlEFRLILTVCGVLLAIGGSIGYGWCIQFHYHISAVLVFAGLMAFGLTWCNNTIMTYLSELLSLRVSSA 481
Cdd:cd17323 241 RLKKKNGGKPEP-EARLPPAFIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASA 319

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 50294418 482 IAVSSFFRNIAAAISSALIAKLCQKMGIGFCFLGLGLINLVSLFSILVLINNRNKW 537
Cdd:cd17323 320 LAANTLVRSIFAAIFPLFAQPMFNNLGVGWAFTLLAFISLAMIPIPFIFYKYGKKI 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
74-490 1.66e-41

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 152.44  E-value: 1.66e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  74 TSFQVSLIFLIVIYNGFLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISIS 153
Cdd:COG2814   4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 154 LMVIINILLASVPkKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLiLLDNN 233
Cdd:COG2814  84 LFALGSLLCALAP-SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL-LADLF 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 234 NWRWLFGFLCIVSGLGLIMVILLLPETLrcivgngdrqwenwsqnendmstqpvdfsspisrwsfvsdigflnpitqdsi 313
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESR---------------------------------------------------- 189

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 314 fkglyPHPPKFSVWTYLRIMTFPPVILTSIANALLFCTYYSISVTLSHFLATEYSYSNLKIGACYVCPGVCMLLGSQIGG 393
Cdd:COG2814 190 -----PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAG 264

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 394 HLSDSMRKswkkenynteyplefRLILTVCGVLLAIGgsigyGWCIQFHYHISAVLVFAGLMAFGLTWCNNTIMTYLSEL 473
Cdd:COG2814 265 RLADRFGR---------------RRLLLIGLLLLALG-----LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324

                       410
                ....*....|....*...
gi 50294418 474 LSLRV-SSAIAVSSFFRN 490
Cdd:COG2814 325 APPEArGRASGLYNSAFF 342
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 90-261 7.67e-29

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 117.68  E-value: 7.67e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  90 FLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPkKI 169
Cdd:cd17320   9 ALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALAS-SI 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 170 GSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLIlLDNNNWRWLFGFLCIVSGLG 249
Cdd:cd17320  88 EQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLL-LLFFGWRAIFVFLALLGLLL 166

                       170
                ....*....|..
gi 50294418 250 LIMVILLLPETL 261
Cdd:cd17320 167 LLLVLLFLPETL 178
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 80-266 1.82e-27

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 112.21  E-value: 1.82e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  80 LIFLIVIYNGFLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIIN 159
Cdd:COG0477  14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 160 ILLASVPkKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLiLLDNNNWRWLF 239
Cdd:COG0477  94 LLCGLAP-SPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGL-LVAALGWRWIF 171

                       170       180
                ....*....|....*....|....*..
gi 50294418 240 gFLCIVSGLGLIMVILLLPETLRCIVG 266
Cdd:COG0477 172 -LINAPLGLLALVLRLRLPESRGLLLA 197
2_A_01_02 TIGR00880
Multidrug resistance protein;
122-260 2.26e-27

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 107.35  E-value: 2.26e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   122 SVFMATFSISPLFW----GALADKGGRKILYIISISLMVIINILLAsVPKKIGSLIFLRIIQAFASSSVISLGAGTVADL 197
Cdd:TIGR00880   1 GLLLAGYALGQLIYsplsGLLTDRFGRKPVLLVGLFIFVLSTAMFA-LSSNITVLIIARFLQGFGAAFALVAGAALIADI 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 50294418   198 TPPKDRGKAMAYFMLGPNLGPILAPIIaGLILLDNNNWRWLFGFLCIVSGLGLIMVILLLPET 260
Cdd:TIGR00880  80 YPPEERGVALGLMSAGIALGPLLGPPL-GGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_1 pfam07690
Major Facilitator Superfamily;
89-488 5.06e-26

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 109.04  E-value: 5.06e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418    89 GFLGPLAGNVFIPALPL-LQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPK 167
Cdd:pfam07690   5 AFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   168 kIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLiLLDNNNWRWLFGFLCIVSG 247
Cdd:pfam07690  85 -LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGL-LASLFGWRAAFLILAILSL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   248 LGLIMVILLLPETLRcivgngdrqwenwsqnendmstqpvdfsspisrwsfvsdigflnpitqdsifKGLYPHPPKFSVW 327
Cdd:pfam07690 163 LAAVLLLLPRPPPES----------------------------------------------------KRPKPAEEARLSL 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   328 TYLRIMTFPPVILTSIANALLFCTYYSISVTLSHFLATEYSYSNLKIGACYVCPGVCMLLGSQIGGHLSDSMRKswkken 407
Cdd:pfam07690 191 IVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGR------ 264

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   408 ynteyplEFRLILTVCGVLLAIGGSIGYGWCIQFHYHISAVLVFAGLMAFGLTWCNNTIMTYLSELLSLRVSSAIAVSSF 487
Cdd:pfam07690 265 -------RRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGS 337


                  .
gi 50294418   488 F 488
Cdd:pfam07690 338 L 338
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 98-473 9.91e-26

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 108.79  E-value: 9.91e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  98 VFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKkIGSLIFLRI 177
Cdd:cd17324  17 VIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS-FALLLLARA 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 178 IQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLI--LLDnnnWRWLFGFLCIVSGLGLIMVIL 255
Cdd:cd17324  96 LAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLgqLLG---WRAAFLAIAVLALLAALLLWR 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 256 LLPETLRcivgngdrqwenwsqnendmstqpvdfsspisrwsfvsdigflNPITQDSIFKGlyphppkfsvwtYLRIMTF 335
Cdd:cd17324 173 LLPSLPP-------------------------------------------KKPGSLGLLSS------------LLLLLRN 197

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 336 PPVILTSIANALLFCTYYSISVTLSHFLATEYSYSNLKIGACYVCPGVCMLLGSQIGGHLSDsmrKSWKKenynteyple 415
Cdd:cd17324 198 PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLAD---RGGRR---------- 264

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 50294418 416 frlILTVCGVLLAIGGSIGYGwciqFHYHISAVLVFAGLMAFGLTWCNNTIMTYLSEL 473
Cdd:cd17324 265 ---ALLIALLLLAAALLLLTL----LGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL 315
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 90-531 3.70e-25

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 107.28  E-value: 3.70e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  90 FLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKkI 169
Cdd:cd17325   6 FLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS-Y 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 170 GSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLiLLDNNNWRWLFGFLCIVSGLG 249
Cdd:cd17325  85 WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGL-LADALGYRAPFLVCAALALLA 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 250 LIMVILLLPETLRcivgngdrqwenwsqNENDMSTQPVDFSSPIsrwsfvsdigflnpitqdsifkglyphppkfsvwty 329
Cdd:cd17325 164 LVLALLLLPEPRP---------------PPNKRAVSAARLRSGL------------------------------------ 192

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 330 LRIMTFPPVILTSIANALLFCTYYSISVTLSHFLATEYSYSNLKIGACYVCPGVCMLLGSQIGGHLSDSMRKswkkenyn 409
Cdd:cd17325 193 RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGR-------- 264

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 410 teyplefRLILTVCGVLLAIGgsigyGWCIQFHYHISAVLVFAGLMAFGLTWCNNTIMTYLSELLSLRV-SSAIAVSSFF 488
Cdd:cd17325 265 -------KPLILIGLLLSAVA-----LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGrGTAMGLFNTA 332

                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 50294418 489 RNIAAAISSALIAKLCQKMGIGFCFLGLGLINLVSLFSILVLI 531
Cdd:cd17325 333 FSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
69-536 4.51e-25

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 106.49  E-value: 4.51e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  69 PYSAYTSFQVSLIFLIVIYNGFLGplagNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILY 148
Cdd:COG2271   3 APSRYRWRILALLFLAYFLNYLDR----SNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 149 IISISLMVIINILLASVPkKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLi 228
Cdd:COG2271  79 AIGLLLWGLATLLFGFAT-SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGW- 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 229 LLDNNNWRWLFGflcIVSGLGLIMVILllpetlrcivgngdrqwenwsqnendmstqpvdfsspisrwsfvsdigflnpi 308
Cdd:COG2271 157 LLAAFGWRAAFL---ILGLPGLLLALL----------------------------------------------------- 180

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 309 tqdsifkglyphppkfsvwtylrimtfpPVILTSIANALLFCTYYSISVTLSHFLATEYSYSNLKIGACYVCPGVCMLLG 388
Cdd:COG2271 181 ----------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVG 232

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 389 SQIGGHLSDSMRKSWKkenynteyplefrlILTVCGVLLAIGGSIGYGWCIqfhyHISAVLVFAGLMAFGLTWCNNTIMT 468
Cdd:COG2271 233 SLLGGWLSDRLGRRRK--------------LVLAIGLLLAALALLLLALLP----SPALAIALLFLAGFGLGGAFGLLWA 294

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50294418 469 YLSELLSLR-VSSAIAVSSFFRNIAAAISSALIAKLCQKMGIGFCFLGLGLINLVSLFSILVLINNRNK 536
Cdd:COG2271 295 LAAELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 90-253 8.11e-25

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 106.10  E-value: 8.11e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  90 FLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPkKI 169
Cdd:cd17321   6 FLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP-SL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 170 GSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLiLLDNNNWRWLFGFLCIVSGLG 249
Cdd:cd17321  85 AFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGL-LLELFGWRWIFLINVPIGLVA 163


                ....
gi 50294418 250 LIMV 253
Cdd:cd17321 164 LLLA 167
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 90-490 5.27e-24

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 103.80  E-value: 5.27e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  90 FLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISIsLMVIINILLASVPKKI 169
Cdd:cd17474   9 LLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGL-LLFGIGGLLCGLSDSF 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 170 GSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLDnnNWRWLFGFLCIVSGLG 249
Cdd:cd17474  88 ALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI--SWRYPFFLLAALIPVA 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 250 LIMVILLLPETLRcivgngdrqwenwsqnendmstqpvdfsspisrwsfvsdigflnpitqdsifKGlyPHPPKFSVWTY 329
Cdd:cd17474 166 FLAILFLLPEPKE----------------------------------------------------KA--KSSSATKLRDL 191

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 330 LRIMTFPPVILTSIANALLFCTYYSISVTLSHFLATEYSYSNLKIGACYVCPGVCMLLGSQIGGHLSdsmrkswkKENYN 409
Cdd:cd17474 192 KKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLL--------KKRFG 263

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 410 TEYPLEFRLILTvCGVLLAIGGSIGYGWciqfhyhisaVLVFAGLMAFGLTWCNNTIMTYLSELLSLRV-SSAIAVSSFF 488
Cdd:cd17474 264 ARRILVIGLLLY-ALSLLLLGFVPSLAL----------LLIAIVLFGLGLGLNLPLLTTLVTELAPEEErGTASSLYNFV 332


                ..
gi 50294418 489 RN 490
Cdd:cd17474 333 RF 334
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
91-261 3.04e-21

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 95.75  E-value: 3.04e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   91 LGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVpKKIG 170
Cdd:PRK11102   2 LMPLAIDMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALA-QTID 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  171 SLIFLRIIQAF--ASSSVIsLGAgTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLdNNNWRWLFGFLCIVSGL 248
Cdd:PRK11102  81 QLIYMRFLHGLaaAAASVV-INA-LMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLV-WFSWHAIFWVLALAAIL 157

                        170
                 ....*....|...
gi 50294418  249 GLIMVILLLPETL 261
Cdd:PRK11102 158 AAALVFFFIPETL 170
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 102-256 7.99e-20

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 91.48  E-value: 7.99e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 102 ALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISIsLMVIINILLASVPKKIGSLIFLRIIQAF 181
Cdd:cd17503  18 ALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTAL-ALFTLGSLLCGLAPNLASLIIFRILQGF 96

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50294418 182 ASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGlILLDNNNWRWLFGFLCIVSGLGLIMVILL 256
Cdd:cd17503  97 GGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGG-WLTDNLSWRWIFYINLPIGILALLLAPLL 170
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 91-261 1.02e-19

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 91.29  E-value: 1.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418    91 LGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPkKIG 170
Cdd:TIGR00710  16 LGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSN-NIE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   171 SLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLdNNNWRWLFGFLCIVSGLGL 250
Cdd:TIGR00710  95 TLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILV-WLSWHAIFAFLSLAGILLS 173

                         170
                  ....*....|.
gi 50294418   251 IMVILLLPETL 261
Cdd:TIGR00710 174 ALIFFILPETL 184
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 102-490 1.64e-18

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 88.20  E-value: 1.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   102 ALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINiLLASVPKKIGSLIFLRIIQAF 181
Cdd:TIGR00711  24 AIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS-LLCGVAPNLELMIIFRVIQGF 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   182 ASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLIlLDNNNWRWLFGFLCIVSGLGLIMVILLLPE-- 259
Cdd:TIGR00711 103 GGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWI-IENYHWRWIFLINVPIGIIVVVVAFFILPRdk 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   260 -----------TLRCIVGNGDRQWENWSQNEND-MSTQPVDFSSPISRWSF----VSDIGFLNPITQDSIFKglyphppk 323
Cdd:TIGR00711 182 paasenfdflgLLLLSVGLGSLLYGLSEGPERGwFDSNEILILSITGLVAIiafvVWELTDDNPLVDLRLFK-------- 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   324 fsvwtyLRIMTFppvilTSIANALLFCTYYSISVTLSHFLATEYSYSNLKIGACYVCPGVCMLLGSQIGGHLSDSmrksw 403
Cdd:TIGR00711 254 ------YRNFTI-----GCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDK----- 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   404 kkenynteypLEFRLILTVCGVLLAIG-GSIGYGWCIQFHYHISAVLVFagLMAFGLTWCNNTIMTY-LSELLSLRVSSA 481
Cdd:TIGR00711 318 ----------IDPRKLVTIGLILYAVGfYWRAFTFTPDTPFLAIALPQF--IRGFGMGCFFMPLTTIaLSGLPPHKIARG 385


                  ....*....
gi 50294418   482 IAVSSFFRN 490
Cdd:TIGR00711 386 SSLSNFTRQ 394
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 102-267 9.11e-18

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 84.93  E-value: 9.11e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 102 ALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVpKKIGSLIFLRIIQAF 181
Cdd:cd17319  25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFA-TSLTSLYVLRFLLGV 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 182 ASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLdNNNWRWLFGFLCIVSGLGLIMVILLLPETL 261
Cdd:cd17319 104 AEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLL-LFGWRWAFIIEGLLGLLLAVLWWFYLRQVW 182


                ....*.
gi 50294418 262 RCIVGN 267
Cdd:cd17319 183 GLALGY 188
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 94-490 3.55e-17

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 83.24  E-value: 3.55e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  94 LAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPkKIGSLI 173
Cdd:cd06174  10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP-SFWLLL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 174 FLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAG-LILLDNNNWRWLFGFLCIVSGLGLIM 252
Cdd:cd06174  89 LGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGiLASSLGFGWRAVFLIAAALALLAAIL 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 253 VILLLPETLRCIVGNGDRQwenwsqnendmstqpvdfsspisrwsfvsdigflnpitqdsifkglyphPPKFSVWTYLRI 332
Cdd:cd06174 169 LLLVVPDPPESARAKNEEA-------------------------------------------------SSKSVLKLLKRV 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 333 MTFPPVILTSIANALLFCTYYSISVTLSHFLATEYSYSNLKIGACYVCPGVCMLLGSQIGGHLSDsmrkswkkenynteY 412
Cdd:cd06174 200 LKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSD--------------R 265

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50294418 413 PLEFRLILTVCGVLLAIGGSIGYgwciqFHYHISAVLVFAGLMAFGLTWCNNTIMTYLSELLSLR-VSSAIAVSSFFRN 490
Cdd:cd06174 266 LIGRKPLLLIGLLLMALGLALLL-----LAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEiRGTAFGLLNTFGF 339
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 90-260 1.80e-16

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 81.10  E-value: 1.80e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  90 FLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPkKI 169
Cdd:cd17489   6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT-SV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 170 GSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIaGLILLDNNNWRWLFgFLCIVSGLG 249
Cdd:cd17489  85 ALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPAL-GLFLYQHLGFAVLF-IVAAVLALL 162

                       170
                ....*....|.
gi 50294418 250 LIMVILLLPET 260
Cdd:cd17489 163 ALLLVFLVKDP 173
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
101-260 2.03e-15

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 78.00  E-value: 2.03e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 101 PALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPkKIGSLIFLRIIQA 180
Cdd:COG2223  26 VLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV-SYWLLLLLGLLLG 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 181 FASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLiLLDNNNWRWLFGFLCIVSGLGLIMVILLLPET 260
Cdd:COG2223 105 IGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPL-LIAAFGWRNAFLILGILLLVVAVLAWLFLRDP 183
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 82-257 4.94e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 76.85  E-value: 4.94e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  82 FLIVIYNGFLGPLAGNVFIPALPL-LQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIInI 160
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA-L 279

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 161 LLASVPKKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLiLLDNNNWRWLFG 240
Cdd:cd17325 280 LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGF-LYDAFGFATPFL 358

                       170
                ....*....|....*..
gi 50294418 241 FLCIVSGLGLIMVILLL 257
Cdd:cd17325 359 AAAALLLLAAVLFLLLR 375
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 100-262 1.66e-13

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 72.23  E-value: 1.66e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 100 IPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMvIINILLASVPKKIGSLIFLRIIQ 179
Cdd:cd17504  16 SPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIY-TAGSLLAAFAPNLPVLIAGRALQ 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 180 AfASSSVISLGAGTVADLTPPKDRGKAM----AYFMLGPNLGPILAPIIAglillDNNNWRWLFGFLCIVSGLGLIMVIL 255
Cdd:cd17504  95 G-IGGAVFPLAFALVREEFPPERVPVAQgilsATFGIGAGIGLPLGGWIV-----QHLGWRWIFWTAAPVAVLLAALVPL 168


                ....*..
gi 50294418 256 LLPETLR 262
Cdd:cd17504 169 IDLRLLR 175
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 103-257 5.04e-13

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 70.73  E-value: 5.04e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 103 LPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKkIGSLIFLRIIQAFA 182
Cdd:cd17328  22 LPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPN-FWQLLLFRALVGIG 100

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50294418 183 SSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLDNNNWRWLFgflcIVSG-LGLIMVILLL 257
Cdd:cd17328 101 EASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAF----RVTGvLGVLLAILLL 172
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 102-265 9.22e-13

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 69.55  E-value: 9.22e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 102 ALPLLQKEFNVSETTInATVSVFMATF---SISPLFWGALADKGGRKILYIISISLMVIINILLASVPkKIGSLIFLRII 178
Cdd:cd17316  21 VAPVLAAEFSLGLSLL-QTGLLFAAGFlgrPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLP-TPILLLVLRFL 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 179 QAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLI---LLDNNNWRWLFgflcIVSGLGLIMVIL 255
Cdd:cd17316  99 QGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLiplLSGDWGWRILF----LIGALPALLALL 174

                       170
                ....*....|
gi 50294418 256 LLPETLRCIV 265
Cdd:cd17316 175 LRRRTLLLIL 184
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 95-254 1.21e-12

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 69.49  E-value: 1.21e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  95 AGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASvPKKIGSLIF 174
Cdd:cd17370 214 LGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFAL-GSSLWLLLL 292

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 175 LRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLiLLDNNNWRWLFGFLCIVSGLGLIMVI 254
Cdd:cd17370 293 GFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGY-LWDLISPSAAFLFSAVLALIALLLLL 371
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 82-257 1.45e-12

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 69.12  E-value: 1.45e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  82 FLIVIYNGFLGPLagnvfipaLPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINIL 161
Cdd:cd17478   6 FLNDFYQGFLPAL--------LPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 162 LASVPKkIGSLIFLRIIQAFASSSVISLGAGTVAdLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLdnnnwRWLFGF 241
Cdd:cd17478  78 LGFAPN-YWLLLLLVALAGIGSAAFHPEGARLAS-QAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVA-----LFGGLG 150

                       170
                ....*....|....*.
gi 50294418 242 LCIVSGLGLIMVILLL 257
Cdd:cd17478 151 LLILLIIPGLAVALLL 166
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 90-253 1.78e-12

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 68.74  E-value: 1.78e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  90 FLGPLAGNVFIPALPLLQKEFNvSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMvIINILLASVPKKI 169
Cdd:cd17502   6 FLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIF-ELGSLLCGLAPNM 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 170 GSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLIlLDNNNWRWLFGFLCIVSGLG 249
Cdd:cd17502  84 TMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAF-TDHLSWRWCFYINLPIGGLA 162


                ....
gi 50294418 250 LIMV 253
Cdd:cd17502 163 LALL 166
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 99-263 3.28e-12

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 68.17  E-value: 3.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418    99 FIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPkKIGSLIFLRII 178
Cdd:TIGR00881  14 FALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST-SLWVMAALWAL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   179 QAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLDNNNWRWLF---GFLCIVsgLGLIMVIL 255
Cdd:TIGR00881  93 NGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFivpGIIAII--VSLICFLL 170


                  ....*...
gi 50294418   256 LLPETLRC 263
Cdd:TIGR00881 171 LRDSPQSC 178
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
91-260 8.14e-12

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 67.22  E-value: 8.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   91 LGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPkKIG 170
Cdd:PRK11043  17 LGFLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVE-SAA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  171 SLIFLRIIQAF-ASSSVISLGAgTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIaGLILLDNNNWRWLFGFLCIVsGLG 249
Cdd:PRK11043  96 QLLVLRFVQAVgVCSAAVIWQA-LVIDRYPAQKANRVFATIMPLVALSPALAPLL-GAWLLNHFGWQAIFATLFAI-TLL 172

                        170
                 ....*....|.
gi 50294418  250 LIMVILLLPET 260
Cdd:PRK11043 173 LILPTLRLKPS 183
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 90-258 1.29e-11

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 66.06  E-value: 1.29e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  90 FLGPLAGNVFIPALPLLQKEFNV---SETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVP 166
Cdd:cd17330   6 FLDALGFGIVFPVLPFYVREFNKlgaSGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSR 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 167 KKIGsLIFLRIIQAFASSSVISLGAgTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLiLLDNNNWRWLFGFLCIVS 246
Cdd:cd17330  86 NLWL-LFLARFLDGLTGGNVSVAQA-YIADITDEEERAKAFGIISAAFGLGFILGPALGGF-LSTPYGYALPFLVAAALA 162

                       170
                ....*....|..
gi 50294418 247 GLGLIMVILLLP 258
Cdd:cd17330 163 LLNLVLVLFFLP 174
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 66-271 1.56e-11

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 66.23  E-value: 1.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418    66 RDIPYSAYTSFQVSLIFLIVIYNGFLGPLAGNvfipALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRK 145
Cdd:TIGR00895   7 RKQPLSRYQWRAIILSFLIMLMDGYDLAAMGF----AAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   146 ILYIISIsLMVIINILLASVPKKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIA 225
Cdd:TIGR00895  83 RVLLWSI-LLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLA 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 50294418   226 GlILLDNNNWRWLFGFLCIVSGLGLIMVILLLPETLRCIVGNGDRQ 271
Cdd:TIGR00895 162 G-WLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPET 206
Sugar_tr pfam00083
Sugar (and other) transporter;
119-268 1.67e-11

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 66.53  E-value: 1.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   119 ATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKK--IGSLIFLRIIQAFASSSVISLGAGTVAD 196
Cdd:pfam00083  50 LIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKwsVYQLIVGRVLVGIGVGGASVLAPMYISE 129

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50294418   197 LTPPKDRGKAMAYFMLGPNLGPILAPIIaGLILLDNNN---WRWLFGfLCIVSGLGLIMVILLLPETLRCIVGNG 268
Cdd:pfam00083 130 IAPKKLRGALGSLYQLAITFGILLAYIF-GLGLNKTSNsdgWRIPLG-LQLVPALLLIIGLLFLPESPRWLVEKG 202
emrD PRK11652
multidrug transporter EmrD;
78-261 2.34e-11

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 65.70  E-value: 2.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   78 VSLIFLIVIYNGfLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMvI 157
Cdd:PRK11652   7 VNLLFMLVLLVA-VGQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIF-I 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  158 INILLASVPKKIGSLIFLRIIQAfasssvISLGAGTVADLTPPKDR------GKAMAYFMLGPNLGPILAPIIAGLiLLD 231
Cdd:PRK11652  85 LGTLVALFAHSLTVLIAASAIQG------LGTGVGGVMARTLPRDLyegtqlRHANSLLNMGILVSPLLAPLIGGL-LTT 157

                        170       180       190
                 ....*....|....*....|....*....|
gi 50294418  232 NNNWRWLFGFLCIVSGLGLIMVILLLPETL 261
Cdd:PRK11652 158 LFGWRACYLFLLLLGAGVTFSMARWMPETR 187
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
104-256 9.64e-11

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 63.75  E-value: 9.64e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 104 PLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKKIGSLIFLRIIQAFAS 183
Cdd:COG2223 230 PYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLAL 309

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 50294418 184 SSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLDNNNWRWLFGFLCIVSGLGLIMVILL 256
Cdd:COG2223 310 GGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLL 382
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 101-256 1.77e-10

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 63.41  E-value: 1.77e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 101 PALPLLQKEFNVSETTINATVSVFMATfSISPLFWGALADKGGRKILYIISiSLMVIINILLASVPKKIGSLIFLRIIQA 180
Cdd:cd06179  19 AVLPFIVADLGPSSNSTWISTAWSLAQ-AVLGPIVGRLSDLFGRRWFFIGG-NLLGVVGSIVAGTAKSVNMLIGGQALIG 96

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50294418 181 FASSSVISLGAGtVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLDNNN-WRWLFGFLCIVSGLGLIMVILL 256
Cdd:cd06179  97 IGAGTQGLGAAV-ASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAgWRWIFYINAIFNALALILLFFF 172
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 76-254 3.46e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 62.06  E-value: 3.46e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  76 FQVSLIFLIVIYNGFLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKG-GRKILYIISISL 154
Cdd:cd06174 200 LKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLL 279

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 155 MVIINILLASVPKKIgSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLDNNN 234
Cdd:cd06174 280 MALGLALLLLAPSLL-LLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG 358

                       170       180
                ....*....|....*....|
gi 50294418 235 WRWLFGFLCIVSGLGLIMVI 254
Cdd:cd06174 359 LTGAFLVLAVLLLLAAILLL 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
82-217 8.46e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 60.37  E-value: 8.46e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  82 FLIVIYNGFLGPLAGNVFIPALPL-LQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIInI 160
Cdd:COG2814 209 LLLLLLLAFLLGFGFFALFTYLPLyLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG-L 287

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 50294418 161 LLASVPKKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLG 217
Cdd:COG2814 288 LLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_1 pfam07690
Major Facilitator Superfamily;
82-222 1.05e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 60.12  E-value: 1.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418    82 FLIVIYNGFLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIIN-- 159
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAlg 281

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 50294418   160 ILLASVPKKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAP 222
Cdd:pfam07690 282 LLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 98-260 1.23e-09

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 60.39  E-value: 1.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  98 VFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKkIGSLIFLRI 177
Cdd:cd17371  17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQN-YWQLLILRA 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 178 IQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGL---ILLDNNNWRWLFgFLCIVSGLGLIMVI 254
Cdd:cd17371  96 LAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALlfpLLPPEIAWRVLF-LLGALPALLVLFIR 174


                ....*.
gi 50294418 255 LLLPET 260
Cdd:cd17371 175 RFVKEP 180
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 102-267 1.82e-09

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 59.49  E-value: 1.82e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 102 ALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADK-GGRKILYIISI--SLMVIINILLASVPkkIGSLIFLRII 178
Cdd:cd17380  21 AIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRfGGKKVLLLAVAlwSLATLLTPLLAYSS--LPLLILSRIL 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 179 ----QAFASSSVISLGAGTVadltPPKDRGKAMAYFMLGPNLGPILAPIIaGLILLDNNNWRWLFGFLCIVSGLGLIMVI 254
Cdd:cd17380  99 lglgEGVHFPSMTSLFSRWV----PVSERSRAVSIVTAGSYLGTLLGGLI-GPLLLEYYGWPSVFYFFGLLGLLWALVWL 173

                       170
                ....*....|...
gi 50294418 255 LLLPETLRCIVGN 267
Cdd:cd17380 174 IYLPPVWAIIVAH 186
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 101-266 4.27e-09

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 58.35  E-value: 4.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 101 PALPLLQKEFNVSETTI--NATVSVFMATFSISPLFWGALADKGGRKILYIISiSLMVIINILLASVPKKIGSLIFLRII 178
Cdd:cd17315  18 GALLYIAKDLGFGLSTSlqGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIA-AVLYVIGALLSALAPNVWVLIVGRFL 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 179 QAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIA-GLILLDNNNWRWLFGfLCIVSGLGLIMVILLL 257
Cdd:cd17315  97 LGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGlALSLSPPGWWRLMFA-LAAVPALLQLLLMFFL 175


                ....*....
gi 50294418 258 PETLRCIVG 266
Cdd:cd17315 176 PESRALLVG 184
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 78-261 4.51e-09

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 58.37  E-value: 4.51e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  78 VSLIFLIVIYNGFLGPLAGNVFipalPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVI 157
Cdd:cd17365   1 LALCFLIIVLDGFDLAVMGFVA----PALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 158 INILLASVPkKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAgLILLDNNNWRW 237
Cdd:cd17365  77 FTLLTAFAQ-SVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLA-AALIPAFGWRS 154

                       170       180
                ....*....|....*....|....
gi 50294418 238 LFgflcIVSGLGLIMVILLLPETL 261
Cdd:cd17365 155 VF----LLGGVPPLILLPLLRGTL 174
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 84-260 5.62e-09

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 58.01  E-value: 5.62e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  84 IVIYNGFLGPLAGNVFIPALPL-LQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILL 162
Cdd:cd17329   3 VLLIGSFLNRLGFFMVWPFMAIyLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 163 AsVPKKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLDnnNWRWLFGFL 242
Cdd:cd17329  83 G-FAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY--SFRLLFLAA 159

                       170
                ....*....|....*...
gi 50294418 243 CIVSGLGLIMVILLLPET 260
Cdd:cd17329 160 AVLFLLAALVLLFLLPET 177
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 78-257 9.54e-09

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 57.28  E-value: 9.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  78 VSLIFLIVIYNGFLGPLAGNVFIPalplLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVI 157
Cdd:cd17355   5 LAVTFLILILSWGIRYYFGVFIIP----IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 158 INILLASVPkKIGSLIFLRIIQAFASSSVISLGAG-TVADLTPPKDRGKAMAYFMLGPNLG-PILAPIIAGLIllDNNNW 235
Cdd:cd17355  81 GLVLLALAT-SLWQLYLLWGLLGGGGAGTLAAVAFaTVAAWWFERRRGLALGILTAGGGLGsLVFLPLGAALI--EAFGW 157

                       170       180
                ....*....|....*....|..
gi 50294418 236 RWLFGFLCIVSGLGLIMVILLL 257
Cdd:cd17355 158 RTALLVLALLALLVLVPVLLLL 179
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 79-251 1.08e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 57.23  E-value: 1.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  79 SLIFLIVIYngFLGPLAGNVFIPALP-LLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVI 157
Cdd:cd17316 178 RTLLLILLW--FFISFGYYGLTTFLPtYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 158 INILLASVPKKIGSLIFL-RIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLDNNN-- 234
Cdd:cd17316 256 LALPLFYLLSGSPTLLLLlLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGtg 335

                       170
                ....*....|....*...
gi 50294418 235 -WRWLFGFLCIVSGLGLI 251
Cdd:cd17316 336 vPALILALLAIVALIVAL 353
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 83-260 1.92e-08

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 56.48  E-value: 1.92e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  83 LIVIYNGFLGP-LAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKilYIISISLMV--IIN 159
Cdd:cd17345   5 FLGIFIGYAGYyLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPK--RFLAIGLILsaIIN 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 160 ILLASVPKKIGSLIFLrIIQAFASSSVISLGAG----TVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLIL--LDNN 233
Cdd:cd17345  83 ILIGFVPSATSSVGLM-FILLFLNGWFQGMGWPpsgrTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLaiFGDG 161

                       170       180
                ....*....|....*....|....*..
gi 50294418 234 NWRWLFGFLCIVSGLGLIMVILLLPET 260
Cdd:cd17345 162 WWRGAFIFPAIIAIIVAVIVLFLGKDT 188
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 136-263 2.00e-08

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 56.46  E-value: 2.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 136 GALADKGGRKILyIISISLMVIINILLASVPKKIGSLIFLRIIQ-AFASSSVISlgaGTVADLTPPKDRGKAMAY----- 209
Cdd:cd17472  53 GLLSDRIGRKPV-ILFGLLLFIAGSLLAAYATSIYGLILGRALQgSGAISSVVM---ALLADLTREENRTKAMALigasi 128

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 50294418 210 ---FMLGPNLGPILAPIIaglilldnnNWRWLFGFLCIVSGLGLIMVILLLPETLRC 263
Cdd:cd17472 129 giaFAISMVLGPLLAAHL---------GVSGLFLITAILSLVSLLILLFFVPDPPKI 176
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 100-262 3.04e-08

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 55.72  E-value: 3.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 100 IPALPLLQKEFNVSETTINATVSVFMATFSI-----SPLFwGALADKGGRKILYIISISLMVIINILLASVPKkIGSLIF 174
Cdd:cd17388  19 MPVLPTLLREFVGDSADAATHYGVLLALYALmqfifAPIL-GALSDRFGRRPVLLLSLAGAALDYLLMAFAPT-LWWLYL 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 175 LRIIQAFASSSViSLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGliLLDNNNWRWLFGFLCIVSGLGLIMVI 254
Cdd:cd17388  97 GRIIAGITGATG-AVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGG--LLGEISPRAPFLVAAGLNGLNFLLGL 173


                ....*...
gi 50294418 255 LLLPETLR 262
Cdd:cd17388 174 FVLPESLP 181
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 120-258 3.76e-08

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 55.28  E-value: 3.76e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 120 TVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPkKIGSLIFLRIIQAFASSSVISLGAGTVADLTP 199
Cdd:cd17317  30 VQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSP-SYELFLVLRFLVGVTSAGIFTVGFVLGMEIVG 108

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 50294418 200 PKDRGKAMAYFMLGPNLGPILAPIIAGLIlldnNNWRWLfgfLCIVSGLGLIMVILLLP 258
Cdd:cd17317 109 PKYRSFVGILFGLFWALGYMLLALLAYLI----RDWRWL---QLAISLPGLLFLLLLWW 160
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 74-257 9.34e-08

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 54.12  E-value: 9.34e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  74 TSFQVSLIFLIVIYnGFLGPLAGNVFIPALP-LLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISI 152
Cdd:cd17473 192 AALPWKRVLPIYFL-AFLAMLLFYVIPIQLPfLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGF 270

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 153 SLMVIINILLASVPKkIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLDN 232
Cdd:cd17473 271 ALMALGFLLLALASG-LWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLT 349

                       170       180
                ....*....|....*....|....*
gi 50294418 233 NNWRWLFGFLCIVSGLGLIMVILLL 257
Cdd:cd17473 350 GGLSGAFLILGVLALVLAIVLLLLR 374
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 106-268 1.14e-07

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 53.81  E-value: 1.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 106 LQKEFNVSETTINATVSVFMAtfsisplfwGALADKGGRKILYIISISLMVIINILLASVPKKIgSLIFLRIIQAFAsss 185
Cdd:cd17360  35 GWQELIVSSTVAGAAVGAAIG---------GWLNDRFGRRPCILLADALFTIGAIVMAAAPNKE-VLIVGRVLVGLG--- 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 186 vISLGAGTV----ADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLDNNNWRWLFGFLCIVSGLGLIMvILLLPETL 261
Cdd:cd17360 102 -VGIASMTVplyiAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPGGWRWMLGLAAVPAVLQFIG-LLFLPESP 179

                       170
                ....*....|....
gi 50294418 262 R-------CIVGNG 268
Cdd:cd17360 180 RwpstrraLIVGCG 193
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 101-262 1.22e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 53.70  E-value: 1.22e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 101 PALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADK-GGRKILYIISISLMVIINILLASVpKKIGSLIFLRIIQ 179
Cdd:cd17370  20 SILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRtGKRKPLVILGYGLSALAKPLLALA-GSWQLVLLLRILE 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 180 AFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLIL-LDNNNWRWLFGFLCIVSGLGLIMVILLLP 258
Cdd:cd17370  99 RLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLyLLGGNYRTIFLLAAIPALLALLILLFVVK 178


                ....
gi 50294418 259 ETLR 262
Cdd:cd17370 179 EYPR 182
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 102-270 1.23e-07

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 54.11  E-value: 1.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 102 ALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKiLYIISISLMVIINILLASVPKKIGSLIFLRIIQAF 181
Cdd:cd17359  23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRR-KTLLISAVLFFISALGSAFSPNFTIFIIARIIGGL 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 182 ASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPII-------AGLILLDNNNWRWLFGfLCIVSGLGLIMVI 254
Cdd:cd17359 102 AVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVnylianaGGADWLGAEGWRWMLG-LEAIPAILFLLGM 180

                       170
                ....*....|....*.
gi 50294418 255 LLLPETLRCIVGNGDR 270
Cdd:cd17359 181 LFIPESPRWLVSKGKP 196
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
76-257 1.25e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 54.09  E-value: 1.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  76 FQVSLIFLIVIYNGFlgplAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLM 155
Cdd:COG0738   8 RALIAIYLLFFLWGF----ATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 156 VIINILLASVPkKIGSLIFLRIIQAFASSSVISLGAGTVADLTpPKDRGKAMAYFMLGPNLGPILAPIIAGLILLDNNNW 235
Cdd:COG0738  84 ALGLLLFALAP-SYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSL 161

                       170       180
                ....*....|....*....|..
gi 50294418 236 RWLFGFLcIVSGLGLIMVILLL 257
Cdd:COG0738 162 SWHLPYL-ILAVLLLLLALLFL 182
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
 113-265 2.11e-07

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 53.35  E-value: 2.11e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 113 SETTINATVSVFMATFSISPLFWGALADK--GGRKILyIISISLMVIINILLASVPKKIGSLiflriiqaFASSSVISLG 190
Cdd:cd17346  38 SEADAASIYGAYTALVYLTPIIGGWLADKvlGARRTV-FIGGILMALGYLLLALSPFSVSML--------YLGLALIIVG 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 191 AG--------TVADLTPPKD--RGKAMAYFMLGPNLGPILAPIIAGLiLLDNNNWRWLFGFLCIVSGLGLIMVIL---LL 257
Cdd:cd17346 109 NGlfkpnissLVGKLYDENDprRDSGFSIFYMGINLGAFLAPLLCGT-LGDNYGYHYGFGLAAVGMLLGLLIFLLgrkKL 187


                ....*...
gi 50294418 258 PETLRCIV 265
Cdd:cd17346 188 LERKKMLA 195
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 99-256 2.35e-07

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 53.05  E-value: 2.35e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  99 FIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKKIGSLIFLRII 178
Cdd:cd17312  22 FSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLN 101

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50294418 179 QAFASSSVISLGAGTVADLTpPKDRGKAMAYFMLGPNLGPILAPIIAGlILLDNNNWRWLFgflcIVSG-LGLIMVILL 256
Cdd:cd17312 102 GLFQSMGWPPCVKLLGNWFS-KKERGTVYGIWSTSHNFGGILAPILAA-SLASYYGWRAAF----LVPGiVGLVVAIIL 174
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
82-261 3.76e-07

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 52.33  E-value: 3.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   82 FLIVIYngflgPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILyIISISLMVIINIL 161
Cdd:PRK10473  10 ALVLLY-----PAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPV-AIPGAALFIIASL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  162 LASVPKKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLdNNNWRWLFGF 241
Cdd:PRK10473  84 LCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIML-KFPWQSLFYT 162

                        170       180
                 ....*....|....*....|
gi 50294418  242 LCIVSGLGLIMVILLLPETL 261
Cdd:PRK10473 163 MAAMGILVLLLSLFILKETR 182
MFS_ProP cd17366
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ...
 89-265 3.83e-07

Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340924 [Multi-domain]  Cd Length: 377  Bit Score: 52.36  E-value: 3.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  89 GFLGPLAGNVFIPALPllqkefnvSETTINATVSVFMATFSISPL---FWGALADKGGRKILYIISISLMVIINILLASV 165
Cdd:cd17366  19 GYLAVTIGKVFFPGGD--------PTAQLLATFATFAVAFLVRPLgglVFGPLGDKYGRQKVLAITIILMAASTFCIGLL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 166 P--KKIGS-----LIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILL-----DNN 233
Cdd:cd17366  91 PtyATIGVwapilLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLTLllteaQML 170

                       170       180       190
                ....*....|....*....|....*....|..
gi 50294418 234 NWRWLFGFLcIVSGLGLIMVILLLPeTLRCIV 265
Cdd:cd17366 171 DWGWRIPFL-IAAPLGLVGLYLRRP-LLICIG 200
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 90-266 4.15e-07

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 52.26  E-value: 4.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  90 FLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKKI 169
Cdd:cd17476   8 LLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFI 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 170 gSLIFLRIIQAFASSSVISLGAGTVADLTPP-KDRGKAMAYFMLGPNLGPILAPIIAGLIlLDNNNWRWLFGFLCIVSGL 248
Cdd:cd17476  88 -FFIICRALQGLGPAFLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALGGVFGGLF-AQLAWWPWIFWFLAILAAI 165

                       170
                ....*....|....*...
gi 50294418 249 GLIMVILLLPETLRCIVG 266
Cdd:cd17476 166 VAVAAIFWTSPSFIAVLL 183
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 103-257 5.37e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.83  E-value: 5.37e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 103 LPLLQKEFNVSETTInaTVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKKIGSLIFLRIIQAFA 182
Cdd:cd17489 217 LPLYAAERGISNAGL--FFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGF 294

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50294418 183 SSSVISLGAGTVaDLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLIlLDNNNWRWLFGFLCIVSGLGLIMVILLL 257
Cdd:cd17489 295 GLLFPALQALAV-DLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLV-AELFGYRAMFLLAAVVVLLALVLYIFLL 367
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 128-261 6.55e-07

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 51.51  E-value: 6.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 128 FSISPLfWGALADKGGRKILYIISIsLMVIINILLASVPKKIGSLIFLRIIQAFASSSViSLGAGTVADLTPPKDRGKAM 207
Cdd:cd17389  78 FLSSPI-TGAASDVYGRKPVLLLTM-IGLAISYALWAVSRSFTIFLLSRIVGGISKGNV-SLSTAIVADVTSPKKRSKGM 154

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50294418 208 AY----FMLGPNLGPILAPIIAGLILLDNNNW----RWLFGFLCIVSglgLIMVILLLPETL 261
Cdd:cd17389 155 ALigvaFSLGFIIGPMIGAYFASFTRSLGEVFfsmpALFALVLALAD---LLFIFFFLPETL 213
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 100-473 7.46e-07

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 51.47  E-value: 7.46e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 100 IPAL-PLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKKIGSLIFLRII 178
Cdd:cd17475  15 IPALaPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 179 QAFASSsviSLGAGTVADLT--PPKDRGKAMAYFMLGPNLGPILA----PIIAGlilldNNNWRWLFGFLCIVSGLGLIM 252
Cdd:cd17475  95 GAGYGS---VQPGGGRAIMRwfPPRERGLAMGIRQTGVPLGGALAaallPPLAL-----HYGWRAAFVVAGLVSILAAVL 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 253 VILLLPEtlrcivgngdrqwenwsqnendmstqPVDFSSPISRwsfvsdigflnpitQDSIFKGLyphppkfsvwtyLRI 332
Cdd:cd17475 167 FWLFYRE--------------------------PPAASAATES--------------ASTLLRSL------------KEV 194

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 333 MTFPPVILTSIANALLFCTYYSISVTLSHFLATEYSYSNLKIGACYVCPGVCMLLGSQIGGHLSDSMRKSwkkenyntey 412
Cdd:cd17475 195 LRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGG---------- 264

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50294418 413 pleFRLILTVCGVLLAIGGSIGYGWCIQFHYHISAVLVFAGLMAFGLTWcNNTIMTYLSEL 473
Cdd:cd17475 265 ---RRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGW-NGLYLTLVAES 321
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 81-253 9.29e-07

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 51.01  E-value: 9.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  81 IFLIVIYNGFLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVI-IN 159
Cdd:cd17352 184 TFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILgLS 263

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 160 ILLASVPKKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLDNNNWRWLF 239
Cdd:cd17352 264 LLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAF 343

                       170
                ....*....|....*..
gi 50294418 240 ---GFLCIVSGLGLIMV 253
Cdd:cd17352 344 yfcGACLLLSGVLLFLL 360
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
130-259 1.16e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 51.06  E-value: 1.16e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 130 ISPLFWGALAD----KGGRKILYI-ISISLMVIINILLASVPKK---------IGSLIFLRIIQAFASSSVISLGAgtva 195
Cdd:COG2211  61 ITDPLIGALSDrtrtRWGRRRPWIlIGAIPLALSFVLLFTAPDLsptgkliyaLVTYLLLGLAYTLVNIPYSALGA---- 136

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 196 DLTP-PKDRGKAMAYFMLGPNLGPILAPIIAGLILL-----DNNNWRWLFGFLCIVSGLGLIMVILLLPE 259
Cdd:COG2211 137 ELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAafggdAALGYRLTALIFAVLGLLAFLLTFFGTKE 206
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 89-260 1.37e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 50.65  E-value: 1.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  89 GFLGPLAGNVFIPALPLLQKEF-NVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVI---INILLAS 164
Cdd:cd17473   8 STLTVMAGAAIAPALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIggvAGLFLDS 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 165 VPkkigSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGliLLDNNNWRWLFgFLCI 244
Cdd:cd17473  88 LY----ALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGG--ALAEIGWRAPF-LVYL 160

                       170
                ....*....|....*.
gi 50294418 245 VSGLGLIMVILLLPET 260
Cdd:cd17473 161 LALPVLILVLLFLPEP 176
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 90-257 2.54e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 49.92  E-value: 2.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  90 FLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPK-- 167
Cdd:cd06173   9 LLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALlg 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 168 --KIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLdnnnWRWLFGFLCIV 245
Cdd:cd06173  89 slSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVA----LLGPGGAFAIN 164

                       170
                ....*....|..
gi 50294418 246 SGLGLIMVILLL 257
Cdd:cd06173 165 ALSFLLSALLLL 176
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 90-259 3.41e-06

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 49.19  E-value: 3.41e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  90 FLGPLAGNVFIPALPLLQKEFNVSETTINATVS--VFMATFSISPLF---WGALADKGGRKILYIISISLMVIINILLAS 164
Cdd:cd17391   6 FFTGIGFSLIAPFLPLYIEQLGVTSGGLVELWSglAFSSTFLVSAIFspiWGRLADRYGRKPMLLRASLGMAIVIGLMAF 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 165 VPkKIGSLIFLRIIQAFASSSvISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLI--LLDNNNWRWLFGFL 242
Cdd:cd17391  86 VT-NVWQLLILRLLQGVFSGY-VPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLadLFGIRNVFFITGGL 163

                       170
                ....*....|....*..
gi 50294418 243 CIVSGLgliMVILLLPE 259
Cdd:cd17391 164 LFLAFL---LTLFFVKE 177
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 104-260 3.95e-06

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 49.07  E-value: 3.95e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 104 PLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKKIGsLIFLRIIQAFAS 183
Cdd:cd17372  23 PAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMW-LIILRCLVGLGL 101

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50294418 184 SSViSLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLIlLDNNNWRWLFGFlCIVSGLGLIMVILLLPET 260
Cdd:cd17372 102 GGG-PQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLV-MPRLGWRWLLAF-SSVPSSLLLVFYRWTPKT 175
PRK10504 PRK10504
putative transporter; Provisional
 84-258 4.61e-06

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 49.34  E-value: 4.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   84 IVIYNGFLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIiNILLA 163
Cdd:PRK10504  14 IVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTL-GSLFC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  164 SVPKKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGlILLDNNNWRWLFGFLC 243
Cdd:PRK10504  93 ALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGG-LLVEYASWHWIFLINI 171

                        170
                 ....*....|....*
gi 50294418  244 IVSGLGLIMVILLLP 258
Cdd:PRK10504 172 PVGIIGAIATLMLMP 186
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
83-259 9.80e-06

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 47.99  E-value: 9.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   83 LIVIYNG-FLGPLAGNVFIPALPLLQKEFNVS-ETTINA-TVSVFMATF---SISPLFWGALADKGGRKILYIISISLMV 156
Cdd:PRK09874  16 LTVAWLGcFLTGAAFSLVMPFLPLYVEQLGVTgHSALNMwSGLVFSITFlfsAIASPFWGGLADRKGRKIMLLRSALGMG 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  157 IINILLAsVPKKIGSLIFLRIIQAFASSSVISLGAgTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLiLLDNNNWR 236
Cdd:PRK09874  96 IVMVLMG-LAQNIWQFLILRALLGLLGGFVPNANA-LIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGL-LADSYGLR 172

                        170       180
                 ....*....|....*....|...
gi 50294418  237 WLFGFLCIVSGLGLIMVILLLPE 259
Cdd:PRK09874 173 PVFFITASVLFLCFLVTLFCIRE 195
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 130-256 1.11e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 47.57  E-value: 1.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 130 ISPLFWGALADK---GGRKILYIISISLMVIINILLASVPKKIGSLIFLrIIQAFASSSVISLGAGTVADLTPPKDRGKA 206
Cdd:cd17319 230 IGMILGGRLSDRllrGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILL-SLAGFGIGAASPVFWSLPADLLPGEAAATA 308

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 50294418 207 MAYFMLGPNLGPILAPIIAGLILLDNNNWRWLFGFLCIVSGLGLIMVILL 256
Cdd:cd17319 309 GGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
79-261 1.29e-05

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 47.63  E-value: 1.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   79 SLIF--LIVIYNgFLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMV 156
Cdd:PRK15402  11 ALLFplCLVLFE-FATYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFI 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  157 IINILLASVPKkIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYF----MLGPNLGPIlapiiAGLILLDN 232
Cdd:PRK15402  90 LTCLAILLAQS-IEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALManvaLLAPLLGPL-----VGAALIHV 163

                        170       180
                 ....*....|....*....|....*....
gi 50294418  233 NNWRWLFGFLCIVSGLGLIMVILLLPETL 261
Cdd:PRK15402 164 LPWRGMFVLFAALAALSFFGLWRAMPETA 192
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
101-260 1.44e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 47.56  E-value: 1.44e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 101 PALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISIsLMVIINILLASVpkkIGSLIFLriiqa 180
Cdd:COG2807  39 PLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLAL-LLLAAGLLLRSL---APSVALL----- 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 181 FASSSVISLGAGTVADLTP-------PKDRGKAMAYFMLGPNLGPILAPIIAGLiLLDNNNWRWLFGFLCIVSGLGLIMV 253
Cdd:COG2807 110 LAGTALIGAGIAVGNVLLPglikrwfPDRVGLMTGLYTAAMGLGAALAAGLTVP-LAAALGWRGALAVWALLALLALLLW 188


                ....*..
gi 50294418 254 ILLLPET 260
Cdd:COG2807 189 LPLLRRR 195
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 104-261 1.50e-05

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 47.29  E-value: 1.50e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 104 PLLQKEFNVSETTINATVS---VFMATFSISPL---FWGALADKGGRKILYIISISLMVIINILLASVPKK--IGS---- 171
Cdd:cd17367  23 LYFAPQFFPSGDPTVALLStaaVFAVGFLMRPIggwLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYatIGIwapi 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 172 -LIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILL-----DNNNWRWLFGFLciV 245
Cdd:cd17367 103 iLLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHtlgedQMAAWGWRIPFL--L 180

                       170
                ....*....|....*....
gi 50294418 246 SGLGLIMVILL---LPETL 261
Cdd:cd17367 181 GGVLAVVVLWLrrgLEETE 199
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 102-253 2.47e-05

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 46.46  E-value: 2.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 102 ALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADK--GGRKILYIISISLMVIINILLASVPKKIGSLIFLRIIQ 179
Cdd:cd17475 221 LLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRvfGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLL 300

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50294418 180 AFASSSVI---SLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLDNNNWRWLFGFLCIVSGLGLIMV 253
Cdd:cd17475 301 ILLGLFAIgwnGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 106-255 3.06e-05

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 46.37  E-value: 3.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 106 LQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINI---LLASVPKKIGSLIFLRIIQAFA 182
Cdd:cd17369 255 ATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFpffWLLDTGSTWLIVLAAVVVLGVL 334

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50294418 183 SSSVISLGAGTVADLTPPKDRGKAMAyfmLGPNLGPIL----APIIAGLILLDNNNWRWLFGFLCIVSGLGLIMVIL 255
Cdd:cd17369 335 HGMMYGPQAAFLAELFPTRVRYTGAS---LGYQLGAILgggfAPLIATALVAATGSWWPVALYLAALAVISLVAALF 408
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 103-272 3.42e-05

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 46.51  E-value: 3.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   103 LPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIInILLASVPKKIGSLIFLRIIQAFA 182
Cdd:TIGR01299 190 LPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFF-AFFSSFVQGYGFFLFCRLLSGFG 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   183 SSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLIL------------LDNNNWRwLFGFLCIVSGLGL 250
Cdd:TIGR01299 269 IGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIphygwsfqmgsaYQFHSWR-VFVIVCAFPCVFA 347

                         170       180
                  ....*....|....*....|....
gi 50294418   251 IMVILLLPETLRCIVGNG--DRQW 272
Cdd:TIGR01299 348 IGALTFMPESPRFFLENGkhDEAW 371
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 120-262 3.45e-05

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 46.55  E-value: 3.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   120 TVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPkKIGSLIFLRIIQAFASSSVISLGAGTVADLTP 199
Cdd:TIGR00898 132 TQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSP-NYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLP 210

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 50294418   200 PKDRGKAMAYFMLGPNLGPILAPIIAGLILldnnNWRWLFGFLCIVSGLGLIMViLLLPETLR 262
Cdd:TIGR00898 211 KKQRAIVGTLIQVFFSLGLVLLPLVAYFIP----DWRWLQLAVSLPTFLFFLLS-WFVPESPR 268
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 98-259 3.55e-05

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 46.04  E-value: 3.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  98 VFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADK-GGRKILYIISISLMVIINILLASVPKKIGSLIFLR 176
Cdd:cd17335  15 SLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRfGKRKALLLLSLLAAVLFFLSLFFVAQIFWLLLLLV 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 177 IIQAFASSSVISLG-AGTVADLTppKDRGKAMAYFMLGpNLGPILAPIIAGLIL---LDNNNWRWLFGFLCIVSGLGLIM 252
Cdd:cd17335  95 ILGAFFSAPVVPLVdSITLQYLG--EERERYGKQRLWG-SIGFGIAALLVGILIdrsSTYKNYTIAFYVFAVLMLLALLL 171


                ....*..
gi 50294418 253 VILLLPE 259
Cdd:cd17335 172 ALKFPFR 178
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 89-259 3.70e-05

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 46.07  E-value: 3.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  89 GFLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKk 168
Cdd:cd17390   5 GFLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTS- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 169 IGSLIFLRIIQAFASSSvISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLDNNNWRWLFGFLCIVSGL 248
Cdd:cd17390  84 LALLFLSRIPLGIFKHT-QSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIFIL 162

                       170
                ....*....|.
gi 50294418 249 GLIMVILLLPE 259
Cdd:cd17390 163 NAGLVWFLLSK 173
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 104-254 4.10e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 46.00  E-value: 4.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 104 PLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKKIGSLIFLrIIQAFAS 183
Cdd:cd17324 223 PFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGL-VLWGLGF 301

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50294418 184 SSVISLGAGTVADLtPPKDRGKAMAYFMLGPNLGPILAPIIAGLiLLDNNNWRWLFGFLCIVSGLGLIMVI 254
Cdd:cd17324 302 FAAHSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALGGL-VLDHGGWAGVGWVGAALLLLALLLAL 370
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
80-229 4.41e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.05  E-value: 4.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  80 LIFLIVIYngFLGPLAGNVFIPALPL-LQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVII 158
Cdd:COG2211 230 FLLLLLAY--LLFFLALALVAALLLYyFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50294418 159 NILLASV-PKKIGSLIFLRIIQAFASSSVISLGAGTVADLTPP-------KDRGKAMAYFMLGPNLGPILAPIIAGLIL 229
Cdd:COG2211 308 LLLLFFLgPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYdewktgrRREGLYFGIFTFAIKLGQALAGALAGLLL 386
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
73-262 4.83e-05

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 45.97  E-value: 4.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   73 YTSFQVSLIF--LIVIYNgFLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILyII 150
Cdd:PRK15403   8 FARHAATLFFpmALILYD-FAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPV-LI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  151 SISLMVIINILLASVPKKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIiAGLILL 230
Cdd:PRK15403  86 TGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPL-SGAALM 164

                        170       180       190
                 ....*....|....*....|....*....|..
gi 50294418  231 DNNNWRWLFGFLCIVSGLGLIMVILLLPETLR 262
Cdd:PRK15403 165 HFVHWKVLFAIIAVMGLIAFVGLLLAMPETVK 196
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 119-253 5.70e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 45.63  E-value: 5.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 119 ATVSVFMATFS----ISPLFWGALADKGGRKILYIISISLMVIINILLASVPKKIGSLIFLRIIQAFASSSVISLGAGTV 194
Cdd:cd17477 223 AQAALLLAAFVlgglLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALA 302

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 50294418 195 ADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLiLLDNNNWRWLFGFLCIVSGLGLIMV 253
Cdd:cd17477 303 GDRLPGDELVAANAALLLLYGLGSVIGPLLAGA-LMDAFGPHGLFLFLAAVALLFLLFL 360
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 100-272 6.31e-05

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 45.30  E-value: 6.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 100 IPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILL-ASVPKKIGSLIFLRII 178
Cdd:cd17318  41 KDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTpLAARGGYGALIVLRIL 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 179 QAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLIlLDNNNWRWLFGFLCIVSGLGLIMVILLLP 258
Cdd:cd17318 121 QGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFL-CESLGWPSIFYIFGGLGLLWCLLWFFLVL 199

                       170
                ....*....|....
gi 50294418 259 ETLRCIVGNGDRQW 272
Cdd:cd17318 200 PVWAIVVAHFGHNW 213
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 90-259 8.32e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.86  E-value: 8.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  90 FLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPkKI 169
Cdd:cd17477   6 ALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD-SP 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 170 GSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLIllDNNNWRWlFGFLCIVSGLG 249
Cdd:cd17477  85 WVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALV--GTAGALP-FLIAAVLLLLA 161

                       170
                ....*....|
gi 50294418 250 LIMVILLLPE 259
Cdd:cd17477 162 LVPLLLTRRA 171
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 80-257 1.20e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 44.57  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   80 LIFLIVIYNGFLGPLAGnvfiPALPLLQKEFNVSETTINATVSVfmATFSISP--LFWGALADKGGRKILYIISISLMVI 157
Cdd:PRK11551  19 LCFLVALLEGLDLQSAG----VAAPRMAQEFGLDVAQMGWAFSA--GILGLLPgaLLGGRLADRIGRKRILIVSVALFGL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  158 INILLASVpKKIGSLIFLRIIQAF----ASSSVISLGAGTVadltPPKDRGKAMAYFMLGPNLGPILAPIIaGLILLDNN 233
Cdd:PRK11551  93 FSLATAQA-WDFPSLLVARLLTGVglggALPNLIALTSEAV----GPRLRGTAVSLMYCGVPFGGALASVI-GVLAAGDA 166

                        170       180
                 ....*....|....*....|....
gi 50294418  234 NWRWLFgflcIVSGLGLIMVILLL 257
Cdd:PRK11551 167 AWRHIF----YVGGVGPLLLVPLL 186
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 75-257 1.36e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 44.48  E-value: 1.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  75 SFQVSLIFLIVIYNGFLgplagnVFIPALplLQKEFNVSETTINATVSVFMATFSISPLFWGA-LADKGGRKILYIISIS 153
Cdd:cd17474 202 TFLVSAFLYFFLYFAFL------TYLPFL--LELLYGISPIIIGLLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLL 273

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 154 LMVIINILLASVPKkIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGlILLDNN 233
Cdd:cd17474 274 LYALSLLLLGFVPS-LALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFG-LLLEIF 351

                       170       180
                ....*....|....*....|....
gi 50294418 234 NWRWLFgFLCIVSGLGLIMVILLL 257
Cdd:cd17474 352 GLSAPF-LVGAAIALAAAVLLALL 374
MFS_MFSD1 cd17340
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ...
 14-257 1.41e-04

Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340898 [Multi-domain]  Cd Length: 394  Bit Score: 44.19  E-value: 1.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  14 FSITDSIVVQATDDNADKILqevdlsdpNIDKNDTFELRQQVSIKESPLyylrdipysaytsfQVSLIFLI-VIYNGFLG 92
Cdd:cd17340 177 FSLICAIILGLLDKRAERIL--------KKESNKTGEVIKLSDVKDFPL--------------SFWLICIIcVFYYVAVF 234

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  93 PLAGNvfipALPLLQKEFNVSETTINATVS-VFMATFSISPLFwGALADKGGRKILY-IISISLMVIINILLASVpkKIG 170
Cdd:cd17340 235 PFIGL----GTVFFEEKYGFSPSEAAAVNSiVYIISAAASPVF-GFLVDKVGRNILWvLIALVITLLGHLLLAFT--FVN 307

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 171 SLIFLrIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLIlLDNNNWRWLFGFLCIVSGLGL 250
Cdd:cd17340 308 PLIAM-VIMGIGYSMLACALWPMVPLVVPEHQLGTAYGFMQSIQNLGLAVFPIIAGSI-LDKKGYLLLEVFFIACLCVSL 385


                ....*..
gi 50294418 251 IMVILLL 257
Cdd:cd17340 386 IALIILY 392
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 103-230 1.86e-04

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 43.81  E-value: 1.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 103 LPLLQKEFNVSETTINATVS--VFMATF---SISPLFWGALADKGGRKILYIISISLMVIINILLASVPK-----KIGSL 172
Cdd:cd17364  22 TKILGRLYYGGKGSLPSGVSglVNAAALvgtIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGstplgVMGWL 101

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 50294418 173 IFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAgLILL 230
Cdd:cd17364 102 IFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVT-LILS 158
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 102-250 2.59e-04

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 43.53  E-value: 2.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  102 ALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKKIGSLIFlRIIQAF 181
Cdd:PRK03893  42 VLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIA-RLVIGM 120

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50294418  182 ASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLdNNNWRWLF--GFLCIVSGLGL 250
Cdd:PRK03893 121 GMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVP-VWGWRALFfiGILPIIFALWL 190
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 119-257 2.64e-04

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 43.43  E-value: 2.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 119 ATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPkKIGSLIFLRIIQAFASSSVISLGAGTVADLT 198
Cdd:cd17374  39 VAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAP-TFPVYCVLRFLAGFAVSGISINTLILGTEWT 117

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50294418 199 PPKDRGKAMAYFMLGPNLGPILAPIIAGLIlldnNNWRWLF------GFLCIVSGLGLIMVILLL 257
Cdd:cd17374 118 TPRHRALAITLTSCFFSIGQMLLAGLAYAI----RDWRLLQlvvsvpFFLFFLYSWWLPKRTLIL 178
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 71-254 2.66e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 43.31  E-value: 2.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  71 SAYTSFQVSLIFLIVIynGFLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYII 150
Cdd:cd17478 188 STLKGVWRALLLLLII--VFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIA 265

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 151 SISLMVIINILLASVPkKIGSLIFLRIIQAFASSSvISLGAGTVADLTPpkdRGKAMA---YFMLGPNLGPILAPIIAGL 227
Cdd:cd17478 266 SLLLAAPFLLLFLLTP-GIWSYILLVLAGFLLFAS-FPVTVVLAQELLP---GNVGLAsglMMGLSFGLGGIGAPVLGAL 340

                       170       180
                ....*....|....*....|....*..
gi 50294418 228 IllDNNNWRWLFGFLCIVSGLGLIMVI 254
Cdd:cd17478 341 A--DAFGLESVLLILALLPLLGALLAF 365
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 118-260 3.17e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 43.40  E-value: 3.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 118 NATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVI--INILLASVPKKIGSLIFLRIIQAFASSSVISLGAGTVA 195
Cdd:cd17357  52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVssLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQ 131

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50294418 196 DLTPPKDRGKAMAYFMLGPNLGPILAPIIA-GLILLDNNNWRWLFGFLCIVSGLGLIMvILLLPET 260
Cdd:cd17357 132 EISPSELRGALGSLTQIGVTLGILLGQVFGlPSVLGTETLWPYLLFFPGIPALLQLAA-LPFFPES 196
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
103-256 3.24e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 43.32  E-value: 3.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 103 LPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKKIGSLIFLrIIQAFA 182
Cdd:COG2807 238 LPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWA-VLLGLG 316

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50294418 183 SSSVISLGAGTVADLTP-PKDRGKAMAYFMLGPNLGPILAPIIAGLILLDNNNWRWLFGFLCIVSGLGLIMVILL 256
Cdd:COG2807 317 QGGLFPLALTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 101-268 3.43e-04

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 43.33  E-value: 3.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 101 PALPLLQKEFNVSETTINATVSVFMATFSISPLFW----GALADKGGRKiLYIISISLMVIINILLASVPKKIGSLIFLR 176
Cdd:cd17358  23 PALPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGallsGKLADRIGRK-RTLLISAIPCILGWLLIAFAKDVWMLYLGR 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 177 IIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLIlldnnNWRWLFGFLCIVSGLgLIMVILL 256
Cdd:cd17358 102 FLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFL-----PWRTLALIGAIPPVV-FLILLFF 175

                       170
                ....*....|..
gi 50294418 257 LPETLRCIVGNG 268
Cdd:cd17358 176 IPESPRWLAKKG 187
Sugar_tr pfam00083
Sugar (and other) transporter;
123-260 3.67e-04

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 43.03  E-value: 3.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   123 VFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASV---------PKKIGSLIFLRIIQAFASSSVISLGAGT 193
Cdd:pfam00083 295 IVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFVILGIVallgvsksdWAGIVAIVFIALFIAFFAMGWGPVPWVI 374

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50294418   194 VADLTPPKDRGKAMAYFMLGPNLGPILAPIIAgLILLDNNNWRWLFGFLCIVSGLGLIMVILLLPET 260
Cdd:pfam00083 375 VSELFPLSVRSKAMALATAANWLANFLIGFLF-PIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPET 440
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 80-256 3.74e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 42.98  E-value: 3.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  80 LIFLIViyngFLGPLAGNVFIPALPLLQKEFNVSETTINAT-VSVFMATFSISPLFWGALADKGGRKILYIISISLMVII 158
Cdd:cd17353 217 LLWLMF----FLNATAGLMLIGQAKPIGQEFAGLDAGIAALaVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVA 292

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 159 NILLASVPKKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLdNNNWRWL 238
Cdd:cd17353 293 MFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLY-TGGYNAA 371

                       170
                ....*....|....*...
gi 50294418 239 FGFLCIVSGLGLIMVILL 256
Cdd:cd17353 372 FIIAAALSLVALALALLL 389
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 94-258 4.04e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 42.69  E-value: 4.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  94 LAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLAsVPKKIGSLI 173
Cdd:cd17333  10 LTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIF-ATPSIYLFV 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 174 FLRIIQAFASSSVISLGAGTVADLTpPKDRGKAMAYFMLGPNLGPILAPIIAGLILLDNNNWRWLFgflCIVSGLGLIMV 253
Cdd:cd17333  89 VLMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAY---LIIGLIYLLLA 164


                ....*
gi 50294418 254 ILLLP 258
Cdd:cd17333 165 ILILL 169
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 97-260 4.82e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 42.67  E-value: 4.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  97 NVFIPALplLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKKIGSLIFLR 176
Cdd:cd17371 229 TTWLPSY--LTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILG 306

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 177 IIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLiLLDNNNWRWLFGFLCIVSGLGLIMVILL 256
Cdd:cd17371 307 FPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGF-LATSGSLGTAIAVFAAVYYIAGLVLALL 385


                ....
gi 50294418 257 LPET 260
Cdd:cd17371 386 LPET 389
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 133-256 5.82e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 42.19  E-value: 5.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 133 LFWGALADKGGRKILYIISISLMVIINILLASVPKKIGSL-IFLRIIQAFASSSVISLGAgTVADLTPPKDRGKAMAyFM 211
Cdd:cd17365 224 LLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLyVLVFLAGACVNGAQVGLYA-LAARFYPTEVRATGVG-WA 301

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 50294418 212 LG-PNLGPILAPIIAGLILLDNNNWRWLFGFLCIVSGLGLIMVILL 256
Cdd:cd17365 302 LGvGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLL 347
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 133-262 6.58e-04

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 42.24  E-value: 6.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 133 LFWGALADKGGRKILYIISISLMVIINILLASVPKKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFML 212
Cdd:cd17356  63 LISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQL 142

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 50294418 213 GPNLGPILAPIIA-GLILLDNN-NWRWLFGfLCIVSGLGLIMVILLLPETLR 262
Cdd:cd17356 143 AITIGILVAYCINyGTHKLDGSaQWRIPLG-LQIVWGLLLLIGMFFLPESPR 193
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 107-256 6.66e-04

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 42.06  E-value: 6.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 107 QKEFNVSETTInaTVSVFMATFS--ISPLFWGALADKGGRKILYIISISLMVIINILLASVPKKIGSLIFLRIIqAFASS 184
Cdd:COG2270 266 AGVLGFSTTEL--IVFGLLVQIVaaLGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLI-GLVMG 342

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50294418 185 SVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLDNNNWRWLFGFLCIVSGLGLIMVILL 256
Cdd:COG2270 343 GIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSLIVFFVIGLVLLLRV 414
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 102-272 8.64e-04

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 41.83  E-value: 8.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 102 ALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIInILLASVPKKIGSLIFLRIIQAF 181
Cdd:cd17438  21 VLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASF-AFLSSFVQGYGAFLFCRLISGF 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 182 ASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLIL------------LDNNNWRwLFGFLCIVSGLG 249
Cdd:cd17438 100 GIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIphygwgfsmgtnYHFHSWR-VFVIICALPCIA 178

                       170       180
                ....*....|....*....|....*
gi 50294418 250 LIMVILLLPETLRCI--VGNGDRQW 272
Cdd:cd17438 179 SIIALKFMPESPRFLleMGKHDEAW 203
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 78-257 1.06e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 41.45  E-value: 1.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  78 VSLIFLIVIYNGFLGPLagNVFIPalPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVI 157
Cdd:cd06173 211 RLLLLALALFALLGGAL--TVLLP--LLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 158 INILLASVPKKIGSLIFLRIIQAFASSSVISLGAgTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLiLLDNNNWRW 237
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT-LLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGL-LADALGLSA 364

                       170       180
                ....*....|....*....|
gi 50294418 238 LFgflcIVSGLGLIMVILLL 257
Cdd:cd06173 365 VF----LLAGALLLLAALLL 380
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 100-259 1.57e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 41.05  E-value: 1.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 100 IPALPLLQKEFNVSettiNATVSVFMATFSI-----SPLFwGALADK-GGRKILYI--ISISLMVIINILLASVPkkigs 171
Cdd:cd17331  20 QPVLPYLTKKLGVD----SVVFGYLQTTFSVlqlvgGPLF-GRFGDLfGPRAALVLsfLSSALSYLLLAFASSVP----- 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 172 LIFLRIIQAFASSSVisLGAGT-VADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLiLLDNNNWRWLFGFLCIVSGLGL 250
Cdd:cd17331  90 MLFLSRLPSVFMHAM--QAAQMvVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGL-LTKKFGEQAAALVAAVGSLLSI 166


                ....*....
gi 50294418 251 IMVILLLPE 259
Cdd:cd17331 167 VLVILLIPS 175
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 84-224 1.87e-03

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 40.66  E-value: 1.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  84 IVIYNGFLGPLAGNVFIP-ALPLLQKefnvseTTINATVSVF---MATFSI-----SPLFwGALADKGG-RKILYIISIS 153
Cdd:cd17326   3 VMYLTMFLSSLQFSIVLTsIWPYLQK------IDPTATASFFgwvVAAYSLgqlvfSPVF-GYWSNKTSsVKEPLIVSIL 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50294418 154 LMVIINILLASVPK-KIGSLIFL---RIIQAFASSSVISLGAgTVADLTPPKDRGKAMAYFMLGPNLGPILAPII 224
Cdd:cd17326  76 IAIVGNILYALAEYfPSNRKYVMlvaRFLIGVGAGNVAVLRA-YVAAASTLKDRTRAMAVISAAQALGFIVGPAL 149
MFS_BCD_PucC-like cd06176
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ...
 112-255 2.19e-03

Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 349950 [Multi-domain]  Cd Length: 409  Bit Score: 40.56  E-value: 2.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 112 VSETTINATVSVFMAT----FSISPLFWGALADKGGRKIL----YII--------SISLMVIINILLASVPKKIGslifl 175
Cdd:cd06176  28 IVELGLPATLVGLLIAlhylVAPLRVWIGHRSDTHPLRGYrrtpYIWlgmlllalGLALAPFAALLLAGAAFWLG----- 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 176 rIIQAFASSSVISLG---AGT-----VADLTPPKDRGKAMA--YFMLgpNLGPILAPIIAGlILLDNNNWRWLFGFLCIV 245
Cdd:cd06176 103 -LALAVLAFLLYGIGvgaAGTaflalLADLTPEERRPRAVTvvWTML--ILGIIVTAIVFG-RLLDPYSPERLIQVFQIV 178

                       170
                ....*....|
gi 50294418 246 SGLGLIMVIL 255
Cdd:cd06176 179 ALVALLLALL 188
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 104-262 2.29e-03

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 40.57  E-value: 2.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 104 PLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPkKIGSLIFLRIIQAFAS 183
Cdd:cd17441  23 PQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAP-IYSWILVLRGLVGFGI 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 184 SSVISlGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAgLILLDNNNWRWLFgflcIVSGLGLIMVILL---LPET 260
Cdd:cd17441 102 GGVPQ-SVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLA-VFVMPTLGWRWLL----ILSALPLLIFAVLcfwLPES 175


                ..
gi 50294418 261 LR 262
Cdd:cd17441 176 AR 177
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 103-272 2.45e-03

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 40.40  E-value: 2.45e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 103 LPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIInILLASVPKKIGSLIFLRIIQAFA 182
Cdd:cd17439  22 LPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVF-AFFSSFVQGYGTFLFCRLLSGVG 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 183 SSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLIL------------LDNNNWRwLFGFLCIVSGLGL 250
Cdd:cd17439 101 IGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIphygwsfqmgsaYQFHSWR-VFVLVCAFPSVFA 179

                       170       180
                ....*....|....*....|....
gi 50294418 251 IMVILLLPETLRCIVGNG--DRQW 272
Cdd:cd17439 180 IGALTTMPESPRFFLENGkhDEAW 203
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 73-253 2.45e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 40.25  E-value: 2.45e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  73 YTSFQVSLIFLIVIYnGFLGPLAGNVFIPALPLLQK---EFNVSETTIN-ATVSVFMATFSIspLFWGALADKGGRKILY 148
Cdd:cd17330 168 LVLFFLPPLRRLLLV-YFLIALAFAGLESVFSLFLKdrfGFSPSQIGLLlALVGIAGILAQL--LLIPRLAKRLGERKLL 244

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 149 IISISLMVIINILLASVPKkIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLI 228
Cdd:cd17330 245 RLGLLLAIIGLLLLPFASS-VPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPL 323

                       170       180
                ....*....|....*....|....*.
gi 50294418 229 L-LDNNNWRWLFGFLCIVSGLGLIMV 253
Cdd:cd17330 324 YsFLGPGVPFLLAAGLLLIALFLLSL 349
PRK10642 PRK10642
proline/glycine betaine transporter ProP;
89-251 2.72e-03

proline/glycine betaine transporter ProP;


Pssm-ID: 182611 [Multi-domain]  Cd Length: 490  Bit Score: 40.46  E-value: 2.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   89 GFLGPLAGNVFIP-ALPLLQkefnvsettINATVSVFMATFSISPL---FWGALADKGGRKILYIISISLMVIINILLAS 164
Cdd:PRK10642  36 GFVAYALGKVFFPgADPSVQ---------MIAALATFSVPFLIRPLgglFFGMLGDKYGRQKILAITIVIMSISTFCIGL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  165 VP--KKIGS-----LIFLRIIQAFASSSVISLGAGTVADLTPPKDRG--------KAMAYFMLGPNLGPILAPIIAGLIL 229
Cdd:PRK10642 107 IPsyATIGIwapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGfmgswldfGSIAGFVLGAGVVVLISTIVGEANF 186

                        170       180
                 ....*....|....*....|..
gi 50294418  230 LDnnnWRWLFGFLcIVSGLGLI 251
Cdd:PRK10642 187 LD---WGWRIPFF-IALPLGII 204
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 106-267 2.72e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 40.23  E-value: 2.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 106 LQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISiSLMVIINILLASVPKKIGSLIFLRIIQAFASSS 185
Cdd:cd17352  29 LLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAG-GLLAALGLLLSSFATSLWQLYLTYGVLGGLGLG 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 186 VISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGlILLDNNNWRW---LFGFLCIVSGL-GLIMVILLLPETL 261
Cdd:cd17352 108 LIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLR-YLLDNYGWRGallILGGLCLNLCVcGLLLRLLKDPTFV 186


                ....*.
gi 50294418 262 RCIVGN 267
Cdd:cd17352 187 LLALGV 192
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 82-253 3.06e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 39.95  E-value: 3.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  82 FLIVIYNGFLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINIL 161
Cdd:cd17355 212 FWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLAL 291

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 162 LASVPKKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLDNNNWRWLF-- 239
Cdd:cd17355 292 LLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWal 371

                       170
                ....*....|....*
gi 50294418 240 -GFLCIVSGLGLIMV 253
Cdd:cd17355 372 aVALGLIAALLVLPI 386
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 130-272 3.28e-03

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 40.28  E-value: 3.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 130 ISPLFWGALADKGGRKILYIISISLMVIInILLASVPKKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAY 209
Cdd:cd17440  49 VGAFFWGGLADKVGRRQSLLICMSVNGFF-AFLSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSW 127

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50294418 210 FMLGPNLGPILAPIIAGLIL------------LDNNNWRwLFGFLCIVSGLGLIMVILLLPETLRCI--VGNGDRQW 272
Cdd:cd17440 128 LCMFWMIGGIYASAMAWAIIphygwsfsmgsaYQFHSWR-VFVIVCALPCVSSVVALTFMPESPRFLleVGKHDEAW 203
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
 133-230 3.45e-03

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 40.10  E-value: 3.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418   133 LFWGALADKGGRKILYIISISLMVIINILLASVPK-----KIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAM 207
Cdd:TIGR00887  74 LFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGsspksVMATLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMM 153

                          90       100
                  ....*....|....*....|...
gi 50294418   208 AYFMLGPNLGpILAPIIAGLILL 230
Cdd:TIGR00887 154 AAVFAMQGFG-ILAGAIVALIVL 175
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 98-260 3.72e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 39.90  E-value: 3.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  98 VFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADK-GGRKILYIISISLMVIINILLASVPKKIGSLIFlR 176
Cdd:cd17490  14 VYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRiGKRKLFIIIGLLFTVLASLIMILFPSPWGLLIA-R 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 177 IIQAFASSSVISLgagTV--ADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLIlLDNNNWRWLFGFLCIVSGLGLIMVI 254
Cdd:cd17490  93 FLSGIAAATWVSF---TVlyASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLI-AEHFGMRAPFLLAALAGVLGFILSL 168


                ....*.
gi 50294418 255 LLLPET 260
Cdd:cd17490 169 FIKEER 174
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 119-221 4.22e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 39.82  E-value: 4.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 119 ATVSVFmATFSIS----PL---FWGALADKGGRKILYIISISLMVIINILLASVP--KKIGS-----LIFLRIIQAFASS 184
Cdd:cd17369  42 GTLAAF-ATFGVGflarPLggvVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPtyAQIGIlapilLVLLRLLQGLALG 120

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 50294418 185 SVISlGAGTVA-DLTPPKDRGKAMAYFMLGPNLGPILA 221
Cdd:cd17369 121 GEWG-GAVLMAvEHAPPKRRGFYGSFPQLGAPVGLLLA 157
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 128-238 4.32e-03

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 39.64  E-value: 4.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 128 FSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKKIGSLIFlRIIQAFASSSVISLGAGTVADLTPPKDRGKAM 207
Cdd:cd17379  46 FLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIF-RFLQGLFGKGGWMTGYVLVTEFVGSKYRRTVG 124

                        90       100       110
                ....*....|....*....|....*....|.
gi 50294418 208 AYFMLGPNLGPILAPIIAGLIlldnNNWRWL 238
Cdd:cd17379 125 IVYQMFFTLGLLILPGIAYFI----PHWRWL 151
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
105-256 4.36e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.45  E-value: 4.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 105 LLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKKIGSLIFLRIIQAFAS- 183
Cdd:COG0738 236 YLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSl 315

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50294418 184 --SSVISLGAgtvadLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLIlLDNNNWRWLFGFLCIVSGLGLIMVILL 256
Cdd:COG0738 316 mfPTIFSLAL-----DGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFL-ADAFGLRAAFLVPLVCYLLILLLALAL 384
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 111-258 5.19e-03

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 39.60  E-value: 5.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 111 NVSETTINATVSVFMATFSisplfwgalaDKGGRKILYIISISLMVIINILLASVpKKIGSLIFLRIIQAFASSSVISLG 190
Cdd:cd17322  43 NVVNNIVSAVSQPPYAKLS----------DVFGRLELFLVSLLLYVVGTIIMAAS-TNVQTYAAGSVFYNAGYTGLNLLL 111

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50294418 191 AGTVADLTPPKDRGKAMAYFMLgpnlgPILAPI-IAGLI---LLDNNNWRWLFGFLCIVsgLGLIMVILLLP 258
Cdd:cd17322 112 TLILADFSSLKNRGFASAIPSL-----PYIITTwIGGNIaqaALPNSNWRWGYGMWAII--LPLSSLPLVLC 176
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 104-257 5.51e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 39.13  E-value: 5.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 104 PLLQKEFNVSETTINATVSVFMATFSISPLFWGALA-DKGGRKILYIISISLMVIINILLASVPKkIGSLIFLRIIQAFA 182
Cdd:cd17490 219 PLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFAPN-LTLLYLLQALNGFG 297

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50294418 183 SSSVISLGAGTVADLTPPKDRGKAMAYFM----LGPNLGPILAPIIAGLILLDnnnwrwlFGFLCIVSgLGLIMVILLL 257
Cdd:cd17490 298 TGILFPLLMSLSIEGVPAEQRSTAMGFFQaiyaLGMFLGPVLVGIISEAFGLQ-------TGFFVIGV-IALLAAILSL 368
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
 89-260 6.21e-03

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 39.28  E-value: 6.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418  89 GFLGPLAGNVFIPAlpllQKEFNvsetTINATVSVFMATFSISPL---FWGALADKGGRKILYIISISLMVIINILLASV 165
Cdd:cd17368  19 GFFAVYIGRLFFPS----GSEFA----SLLLTFATFGVGFFMRPIgaiVLGAYADRIGRKPAMTLTLAIMALGTLLIALA 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 166 P--KKIG-----SLIFLRIIQAFASSsvISLGAGTV--ADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLI-------L 229
Cdd:cd17368  91 PtyATIGiaaplLVLLARLLQGFAAG--GEVGGVTAylVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLsltltaeA 168

                       170       180       190
                ....*....|....*....|....*....|.
gi 50294418 230 LDNNNWRWLFGFLCIVSGLGLIMViLLLPET 260
Cdd:cd17368 169 LAEWGWRIPFFIGLLIIPLGLWLR-RSLEET 198
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 107-255 6.46e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 39.15  E-value: 6.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 107 QKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKKIGSLIFLRIIQAFaSSSV 186
Cdd:cd17313 273 SSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIG-WATI 351

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50294418 187 ISLGAGTVADLTPPKDR--GKAMAYFMLGPNLGPILAPIIAGlILLDNNNWRWLFGFLCIVSGLGLIMVIL 255
Cdd:cd17313 352 NINPYPLVSDYHSESGRgqGTDTGLLNLAISLAQILVSLLAG-PIIDVKGYGTVFPVAAVASFLSLVGALF 421
MFS_AmpG_like cd17486
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ...
 103-259 7.83e-03

AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341039 [Multi-domain]  Cd Length: 387  Bit Score: 38.73  E-value: 7.83e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 103 LPLLQKEFNVSETTINATvSVFMATFSISPLfWGALADK-----GGRKILYIISISLMVIINILLASVP---KKIGSLIF 174
Cdd:cd17486  19 LQAWLKEAGVDLDTIGLF-SLVGLPYSLKFL-WAPLVDRystpfLGRRRGWILLTQILLMAALIALAFLdpfTNLVLSAL 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50294418 175 LRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAgLILLDNNNWRWLFGFLCIVSGLGLIMVI 254
Cdd:cd17486  97 LFLLVAFFSATQDIAIDAYRIEALEDKEQGAGAGVRVNGYRIGMLVAGAGA-LYLADSLSWSAVYLIMAALMGPGILATL 175


                ....*
gi 50294418 255 LLLPE 259
Cdd:cd17486 176 FAPEP 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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