BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2); This subfamily of KCTD proteins, also called the BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein (BACURD) subfamily, includes KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2). KCTD10 is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. KCTD13 is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. TNFAIP1, also called protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair, cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD10 and KCTD13 BTB domains form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484  17 VKLNIGGCLHYTTIGTLCKQDTMLRAMFSGRLEVLTDSEGWILIDRCGTHFGTILNFLRDGSVALPETTKGIAELLAESK 96
Cdd:cd18369    1 VKLNVGGSLHYTTIGTLTKQDTMLRAMFSGRMEVLTDSEGWILIDRCGKHFGTILNYLRDGSVPLPESRRELAELLAEAK 80

                         90
                 ....*....|.
gi 158295484  97 YYCIEELIEAC 107
Cdd:cd18369   81 YYLVQGLVEQC 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2); This subfamily of KCTD proteins, also called the BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein (BACURD) subfamily, includes KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2). KCTD10 is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. KCTD13 is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. TNFAIP1, also called protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair, cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD10 and KCTD13 BTB domains form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484  17 VKLNIGGCLHYTTIGTLCKQDTMLRAMFSGRLEVLTDSEGWILIDRCGTHFGTILNFLRDGSVALPETTKGIAELLAESK 96
Cdd:cd18369    1 VKLNVGGSLHYTTIGTLTKQDTMLRAMFSGRMEVLTDSEGWILIDRCGKHFGTILNYLRDGSVPLPESRRELAELLAEAK 80

                         90
                 ....*....|.
gi 158295484  97 YYCIEELIEAC 107
Cdd:cd18369   81 YYLVQGLVEQC 91

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484    16 YVKLNIGGCLHYTTIGTLCKQDTMLRAMFSGRLEVLTDSEgWILIDRCGTHFGTILNFLRDGSVALPETTkgIAELLAES 95
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSE-IYLDDVSPEDFRALLNFLYTGKLDLPEEN--VEELLELA 77

                           90       100
                   ....*....|....*....|
gi 158295484    96 KYYCIEELIEACEKVLAKKE 115
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2); This subfamily of KCTD proteins, also called the BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein (BACURD) subfamily, includes KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2). KCTD10 is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. KCTD13 is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. TNFAIP1, also called protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair, cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD10 and KCTD13 BTB domains form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484  17 VKLNIGGCLHYTTIGTLCKQDTMLRAMFSGRLEVLTDSEGWILIDRCGTHFGTILNFLRDGSVALPETTKGIAELLAESK 96
Cdd:cd18369    1 VKLNVGGSLHYTTIGTLTKQDTMLRAMFSGRMEVLTDSEGWILIDRCGKHFGTILNYLRDGSVPLPESRRELAELLAEAK 80

                         90
                 ....*....|.
gi 158295484  97 YYCIEELIEAC 107
Cdd:cd18369   81 YYLVQGLVEQC 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in tumor necrosis factor, alpha-induced protein 1, endothelial (TNFAIP1); TNFAIP1, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (BACURD2), or protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair and cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The BTB domains of other BACURD subfamily members, KCTD10 and KCTD13, form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484  14 SQYVKLNIGGCLHYTTIGTLCKQDTMLRAMFSGRLEVLTDSEGWILIDRCGTHFGTILNFLRDGSVALPETTKGIAELLA 93
Cdd:cd18401    2 NKYVRLNVGGSLYYTTVQVLTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVALPKSRQEIKELMA 81

                         90       100
                 ....*....|....*....|..
gi 158295484  94 ESKYYCIEELIEACEKVLAKKE 115
Cdd:cd18401   82 EAKYYLIQGLVDMCQAALQDKK 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana FH protein interacting protein FIP2 and similar proteins; FIP2 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484  17 VKLNIGGCLHYTTIGTLCK-QDTMLRAMFSGRLEVLTDSEGWILIDRCGTHFGTILNFLRDGSVALPETT-KGIAELLAE 94
Cdd:cd18376    1 VKLNVGGQKFTTTLDTLTKdPDSMLAAMFSGRHSLKKDEDGSYFIDRDGTHFRHILNYLRDGEVKIPTEDrSVLKELLEE 80

                 ....*....
gi 158295484  95 SKYYCIEEL 103
Cdd:cd18376   81 AEYYQLRGL 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 7 (KCTD7); KCTD7 is a BTB/POZ domain-containing protein that has an impact on K+ fluxes, neurotransmitter synthesis, and neuronal function. It functions as a regulator of potassium conductance in neurons, and is involved in the control of excitability of cortical neurons. Mutations in KCTD7 may cause progressive myoclonus epilepsy (PME). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484  17 VKLNIGGcLHYTT-IGTLCK-QDTMLRAMFSGRLEVLTDSEGWILIDRCGTHFGTILNFLRDGSvaLPETTKGIAeLLAE 94
Cdd:cd18366    6 VPLNVGG-MHFTTrLSTLRKyEDSMLAAMFSGRHHIPKDSEGRYFIDRDGSYFGYILNFLRDGD--LPPRERARA-VYKE 81

                         90
                 ....*....|.
gi 158295484  95 SKYYCIEELIE 105
Cdd:cd18366   82 AQYYGIGPLIE 92

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484   17 VKLNIGGCLHYTTIGTLCKQ-DTMLRAMFSGRLEVLTDSEGWILIDRCGTHFGTILNFLRDGsVALPETT-KGIAELLAE 94
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFpDTRLGRLLELECDDYDDDTNEYFFDRSPKHFETILNFYRTG-GKLHRPEeVCLDEFLEE 79

                          90
                  ....*....|....
gi 158295484   95 SKYYCIEEL-IEAC 107
Cdd:pfam02214  80 AEFYGLDELaLELC 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6); KCTD6, also called KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3 (KCASH3), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5) as well as suppressing histone deacetylase and Hedgehog activity in medulloblastoma. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484  17 VKLNIGGCLHYTTIGTLCK-QDTMLRAMFSGRLEVLTDSEGWILIDRCGTHFGTILNFLRDGSVALPETTKGIAELLAES 95
Cdd:cd18394    5 VTLNVGGHLYTTSLSTLTRyPDSMLGAMFRGDFPTARDSQGNYFIDRDGPLFRYILNFLRTSELTLPVDFKEFDLLRKEA 84

                         90
                 ....*....|
gi 158295484  96 KYYCIEELIE 105
Cdd:cd18394   85 DFYQIEPLIQ 94

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484    16 YVKLNIGGCLHYTTIGTLCKQDTMLRAMFSGRLEVLTDSEgWILIDRCGTHFGTILNFLRDGSVALPETTkgIAELLAES 95
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSE-IYLDDVSPEDFRALLNFLYTGKLDLPEEN--VEELLELA 77

                           90       100
                   ....*....|....*....|
gi 158295484    96 KYYCIEELIEACEKVLAKKE 115
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484  17 VKLNIGGCLHYTTIGTLCKQ-DTMLRAMFSG--RLEVLTDSEGWILIDRCGTHFGTILNFLRDGSVALPETTKGIAELLA 93
Cdd:cd18367    5 VELNVGGQVYTTSLSTLIKDpDSLLGRMFSGknRQELARDSKGRYFLDRDGVLFRYILDYLRNQKLVLPENFPERERLKR 84

                         90
                 ....*....|...
gi 158295484  94 ESKYYCIEELIEA 106
Cdd:cd18367   85 EAEYFQLPELVKA 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4); KCTD4 is a BTB/POZ domain-containing protein with an unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484  17 VKLNIGGCLHYTTIGTLCKQ-DTMLRAMFSGRLEVLTDSEGWILIDRCGTHFGTILNFLRDGSVALPETTKGIAELLAES 95
Cdd:cd18364    2 VTLNVGGYLYITQRQTLTKYpDSFLEGMVNGKIQCTVDADGNYFIDRDGLLFRHVLNFLRNGELLLPEGFQENQLLALEA 81

                 ...
gi 158295484  96 KYY 98
Cdd:cd18364   82 DFY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484  17 VKLNIGGCLHYTTIGTLCKQ-DTMLRAMFSGRLEVLTDS-EGWILIDRCGTHFGTILNFLRDGSVALPETTKGIAELLAE 94
Cdd:cd18361    1 VHIDVGGHIYTSSLETLTKYpESRLGKLFNGSIPIVLDSlKQHYFIDRDGKMFRHILNFLRTSKLLLPDDFTEFDLLYEE 80

                         90
                 ....*....|....
gi 158295484  95 SKYYCIEELIEACE 108
Cdd:cd18361   81 ARYYELQPMVKQLE 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD8; KCTD8, a BTB/POZ domain-containing protein, is an auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. It interacts as a tetramer with GABRB1 and GABRB2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484  17 VKLNIGGCLHYTTIGTLCK-QDTMLRAMFSGRL--EVLTDSEGWILIDRCGTHFGTILNFLRDGSVALPETTKGIAELLA 93
Cdd:cd18396    6 VELNVGGQVYVTKHSTLLSvPDSTLASMFSRRAarELPRDNRGRFFIDRDGFLFRYVLDYLRDKQLALPDHFPEKERLLR 85

                         90
                 ....*....|.
gi 158295484  94 ESKYYCIEELI 104
Cdd:cd18396   86 EAEYFQLGDLV 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16); KCTD16 is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484  17 VKLNIGGCLHYTTIGTLCK-QDTMLRAMFSGRLEVLTD----SEGWILIDRCGTHFGTILNFLRDGSVALPETTKGIAEL 91
Cdd:cd18398    5 VELNVGGQVYFTRHATLVSiPHSLLWKMFSPKRDTANDlakdSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPEKGRL 84

                         90
                 ....*....|....
gi 158295484  92 LAESKYYCIEELIE 105
Cdd:cd18398   85 KREAEYFQLPDLVK 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15); KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains, closely related to KCTD15, form pentamers.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484  17 VKLNIGGCLHYTTIGTLCK-QDTMLRAMFSGRLEVLTDS-EGWILIDRCGTHFGTILNFLRDGSVALPETTKGIAELLAE 94
Cdd:cd18388    4 VHIDVGGHMYTSSLATLTKyPDSRISRLFNGTEPIVLDSlKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFNLLYEE 83

                         90
                 ....*....|....*
gi 158295484  95 SKYYCIEELIEACEK 109
Cdd:cd18388   84 AKYYQLQPMVKELER 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484  15 QYVKLNIGGCLHYTTIGTLCKQDTMlramFSGRL-----EVLTDSE--GWILIDRCGTHFGTILNFLRDGSVALpetTKG 87
Cdd:cd18389    1 KWVRLNVGGTYFVSTKQTLCRDPKS----FLYRLcqedpDLDSDKDetGAYLIDRDPTYFGPILNYLRHGKLII---NKE 73

                         90       100       110
                 ....*....|....*....|....*....|....
gi 158295484  88 IAE--LLAESKYYCIEELIeaceKVLAKKERESE 119
Cdd:cd18389   74 LAEegVLEEAEFYNIASLV----RLVKERIRDNE 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484  17 VKLNIGGCLHYTTIGTLC-KQDTMLRAMFSGRLEVLTDSEGWILIDRCGTHFGTILNFLRDGSVAlPETTKGiAELLAES 95
Cdd:cd18393    4 IHLNVGGKRFSTSRQTLTwIPDSFFSSLLSGRISTLKDETGAIFIDRDPTVFAPILNFLRTKELD-PRGIHV-SLLLHEA 81

                         90
                 ....*....|....*...
gi 158295484  96 KYYCIEELI---EACEKV 110
Cdd:cd18393   82 QFYGITPLVrrlQLCEEL 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3); KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484  17 VKLNIGGCLHYTTIGTLC-KQDTMLRAMFSGRLEVLTDSEGWILIDRCGTHFGTILNFLRDGSVALpettKG--IAELLA 93
Cdd:cd18392    4 IQLNVGGTRFSTSRQTLMwIPDSFFSSLLSGRISSLKDETGAIFIDRDPTAFVPILNFLRTKELDL----RGvnINVLRH 79

                 ....*..
gi 158295484  94 ESKYYCI 100
Cdd:cd18392   80 EAEFYGI 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158295484  17 VKLNIGGCLHYTTIGTLCK-QDTMLRAMFSGRLEVLTDSEGWILIDRCGTHFGTILNFLRDGSVALPETTKGIAELLAES 95
Cdd:cd18375    3 VTLNVGGKKFTTRPSTLRRfPDSRLARMLDGKDQDFKVVNGQFFVDRDGSLFSYILDYLRTGQLTLPTEFSDYNRLAREA 82

                 ...
gi 158295484  96 KYY 98
Cdd:cd18375   83 EFY 85