NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2177253387|ref|XP_045705767|]
View 

alpha-2,8-sialyltransferase 8E isoform X2 [Phyllostomus hastatus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 134-406 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467718  Cd Length: 273  Bit Score: 585.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 134 SEANQFKSTLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYNRSQFKKCAVVGNGGILKNSR 213
Cdd:cd23990     1 TEANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 214 CGREINSADFVFRCNLPPISEKYTVDVGVKTDVVTVNPSIITDRFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDV 293
Cdd:cd23990    81 CGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 294 SIRVKYVLDDFQSPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILATAALELCEEVHLFGFWAFPMNPSGLYITHHY 373
Cdd:cd23990   161 SIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHY 240

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2177253387 374 YDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHT 406
Cdd:cd23990   241 YDNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
 
Name Accession Description Interval E-value
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 134-406 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 585.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 134 SEANQFKSTLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYNRSQFKKCAVVGNGGILKNSR 213
Cdd:cd23990     1 TEANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 214 CGREINSADFVFRCNLPPISEKYTVDVGVKTDVVTVNPSIITDRFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDV 293
Cdd:cd23990    81 CGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 294 SIRVKYVLDDFQSPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILATAALELCEEVHLFGFWAFPMNPSGLYITHHY 373
Cdd:cd23990   161 SIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHY 240

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2177253387 374 YDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHT 406
Cdd:cd23990   241 YDNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 154-401 9.24e-92

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 277.18  E-value: 9.24e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 154 FTTQKNTPLGTKLKYEvDTSGIYHINQEIFRMFPKDMPYNRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIs 233
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 234 EKYTVDVGVKTDVVTVNP-SIITDRFHKL--EKWRRPFYRVLQVYE--NASVLLPAFYNTRNTDVSIRVKYVLDDFQSPQ 308
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLgfSHPRDPFVEFVLVPFkgRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 309 A---VYYFHPQYLVNVSRYWL-SLGVRAKRISTGLILATAALELCEEVHLFGFWAFPMNPsglYITHHYYDNVKPRP--- 381
Cdd:pfam00777 159 DpdkVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSR---GNSHHYYDNVLMKKggf 235

                         250       260
                  ....*....|....*....|.
gi 2177253387 382 -GFHAMPSEIFNFLHLHSRGI 401
Cdd:pfam00777 236 yGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 134-406 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 585.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 134 SEANQFKSTLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYNRSQFKKCAVVGNGGILKNSR 213
Cdd:cd23990     1 TEANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 214 CGREINSADFVFRCNLPPISEKYTVDVGVKTDVVTVNPSIITDRFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDV 293
Cdd:cd23990    81 CGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 294 SIRVKYVLDDFQSPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILATAALELCEEVHLFGFWAFPMNPSGLYITHHY 373
Cdd:cd23990   161 SIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHY 240

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2177253387 374 YDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHT 406
Cdd:cd23990   241 YDNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 134-406 2.49e-170

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 477.13  E-value: 2.49e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 134 SEANQFKSTLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYNRSQFKKCAVVGNGGILKNSR 213
Cdd:cd23971     1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 214 CGREINSADFVFRCNLPPISekYTVDVGVKTDVVTVNPSIITDRFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDV 293
Cdd:cd23971    81 CGREIDSADFVIRCNLPPLN--DSKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 294 SIRVKYVLDDFQSPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILATAALELCEEVHLFGFWAFPMNPSGLYITHHY 373
Cdd:cd23971   159 SLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHY 238

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2177253387 374 YDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHT 406
Cdd:cd23971   239 YDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 135-404 2.37e-125

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 363.30  E-value: 2.37e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 135 EANQFKSTLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYNRSQFKKCAVVGNGGILKNSRC 214
Cdd:cd23991     2 EHENFRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSSC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 215 GREINSADFVFRCNLPPISEKYTVDVGVKTDVVTVNPSIITDRFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVS 294
Cdd:cd23991    82 GAEIDQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTALS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 295 IRVKYVLDDFQSPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILATAALELCEEVHLFGFWAFPMNPSGLYITHHYY 374
Cdd:cd23991   162 FKVYYTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHYY 241

                         250       260       270
                  ....*....|....*....|....*....|
gi 2177253387 375 DNVKPRPGFHAMPSEIFNFLHLHSRGILRV 404
Cdd:cd23991   242 DNQLPKPGFHSMPKEFYQLLQLHSKGILKL 271
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 139-405 1.77e-103

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 307.53  E-value: 1.77e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 139 FKSTLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYNRsQFKKCAVVGNGGILKNSRCGREI 218
Cdd:cd23989     6 FRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQL-PLKKCSVVGNGGILKNSGCGQQI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 219 NSADFVFRCNLPPISEKYTVDVGVKTDVVTVNPSIITDRFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVK 298
Cdd:cd23989    85 DRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVY 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 299 YVLDDFQSPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILATAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVK 378
Cdd:cd23989   165 YTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVL 244

                         250       260
                  ....*....|....*....|....*..
gi 2177253387 379 PRPGFHAMPSEIFNFLHLHSRGILRVH 405
Cdd:cd23989   245 PDSGFHAMPEEFLQLWHLHKSGVLRMQ 271
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 136-406 3.60e-95

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 286.46  E-value: 3.60e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 136 ANQFKSTLSRCCNaPSFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYNRSQFKKCAVVGNGGILKNSRCG 215
Cdd:cd23963     3 LDKFRKELERLLN-TRKLFLTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 216 REINSADFVFRCNLPPIsEKYTVDVGVKTDVVTVNPSIITDRFHKL--EKWRRPFYRVLQVYENASVLLPAFYNTRNTDV 293
Cdd:cd23963    82 KEIDSHDFVIRCNLPPI-KGFEKDVGRKTNLTTLNPSILKRRYNSLkkNRDRDKFLNRLKEYNGSILWYPKFSFKSSTNL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 294 SIRVKYVLDDFQSPQAVYYFHPQYLVNVSRYWLSLGVRaKRISTGLILATAALELCEEVHLFGFWAFPMNPSGLYITHHY 373
Cdd:cd23963   161 LLKAARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGLE-KRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPYHY 239

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2177253387 374 YDNVKPRP--GFHAMPSEiFNFLH-LHSRGILRVHT 406
Cdd:cd23963   240 YDDLSPSTknKVHNMPEE-FKLLReLHKKGVLKLHT 274
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 154-401 9.24e-92

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 277.18  E-value: 9.24e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 154 FTTQKNTPLGTKLKYEvDTSGIYHINQEIFRMFPKDMPYNRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIs 233
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 234 EKYTVDVGVKTDVVTVNP-SIITDRFHKL--EKWRRPFYRVLQVYE--NASVLLPAFYNTRNTDVSIRVKYVLDDFQSPQ 308
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLgfSHPRDPFVEFVLVPFkgRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 309 A---VYYFHPQYLVNVSRYWL-SLGVRAKRISTGLILATAALELCEEVHLFGFWAFPMNPsglYITHHYYDNVKPRP--- 381
Cdd:pfam00777 159 DpdkVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSR---GNSHHYYDNVLMKKggf 235

                         250       260
                  ....*....|....*....|.
gi 2177253387 382 -GFHAMPSEIFNFLHLHSRGI 401
Cdd:pfam00777 236 yGVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 163-406 2.34e-61

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 199.56  E-value: 2.34e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 163 GTKLKYEVDTSGIYHINQEIFRMFPKDMPYNRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTVDVGV 242
Cdd:cd23969    30 GDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPV-EGYEKDVGT 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 243 KTDVVTVNPSIITDRFHKL--EKWRRPFYRVLQVYENASVLLPAFYNTRNTDvsiRVKYVLD---DFQSPQAVYYFHPQY 317
Cdd:cd23969   109 KSNLTTMNPSVIPHAYGDLvnATDKEKFVERLRQLGDSILWIPAFVSKGGEE---HVQWTNEiilKHKLNVKTAYPPLRL 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 318 LVNVSRYWLSLGVRAKRISTGLILATAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPR--PGFHAMPSEIFNFLH 395
Cdd:cd23969   186 NHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYHYYDNRKYLttARPHKMPEEFRALRS 265

                         250
                  ....*....|.
gi 2177253387 396 LHSRGILRVHT 406
Cdd:cd23969   266 LHQRGALRLHT 276
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 132-406 6.77e-61

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 198.77  E-value: 6.77e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 132 NISEANQFKSTLSRCCNAPSFLFTTQKNTPLGTKLKYevDTSG---IYHINQEIFRMFPKDMPYNRSQFKKCAVVGNGGI 208
Cdd:cd23970     2 NKTALLHQRKEIRQYFDVIKNISLTKKDVRIGQLMHF--DYSShkyVFSISPNLRSLLPEVSPFQNKHYNTCAVVGNSGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 209 LKNSRCGREINSADFVFRCNLPPIsEKYTVDVGVKTDVVTVNPSIITDRFHKL--EKWRRPFYRVLQVYENASVLLPAF- 285
Cdd:cd23970    80 LTNSQCGNEIDKSDFVFRCNFAPT-EGFEKDVGRKTNLTTFNPSILEKYYNNLltIQDRNNFFLSLKKLDGAILWIPAFf 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 286 YNTRNTDVSIRVKYVLDDFQSPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILATAALELCEEVHLFGFWAFPMNPS 365
Cdd:cd23970   159 FHTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPT 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2177253387 366 GLYITHHYYD------NVKPRPgFHAMPSEIFNFLHLHSRGILRVHT 406
Cdd:cd23970   239 GTPLPYHYYDkkgtkfTTKWQE-SHQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 163-406 3.73e-56

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 186.30  E-value: 3.73e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 163 GTKLKYEVDTSGIYHINQEIFRMFPKDMPYNRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEkYTVDVGV 242
Cdd:cd23987    30 GDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEE-YAKDVGT 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 243 KTDVVTVNPSIITDRFHKL--EKWRRPFYRVLQVYENASVLLPAFYNTRNTDvsiRVKYVLD-DFQSPQAVYYFHP--QY 317
Cdd:cd23987   109 KTDLVTMNPSVVQRAFEDLvnETWKEKFLQRLQSLNGSILWIPAFMAKGGEE---RVEWVNDlILKHHINVRTAYPslRL 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 318 LVNVSRYWLSLGVRAKRISTGLILATAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVK----PRPGFHAMPSEIFNF 393
Cdd:cd23987   186 LHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYHYYDSLKygytSQASPHTMPLEFKAL 265

                         250
                  ....*....|...
gi 2177253387 394 LHLHSRGILRVHT 406
Cdd:cd23987   266 KNLHQQGALKLTV 278
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 163-406 1.76e-51

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 173.99  E-value: 1.76e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 163 GTKLKYEVDTSGIYHINQEIFRMFPKDMPYNRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEkYTVDVGV 242
Cdd:cd23988    30 GDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVE-FAADVGT 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 243 KTDVVTVNPSIITDRFHKL--EKWRRPFYRVLQVYENASVLLPAFY-NTRNTDVSIRVKYVLDDFQSPQAVYyfhPQY-L 318
Cdd:cd23988   109 KSDFITMNPSVVQRAFGGFrnESDREKFVHRLSMLNDSVLWIPAFMvKGGEKHVEWVNALILKNKLKVRTAY---PSLrL 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 319 VNVSR-YWLSLGVRAKRISTGLILATAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPR----PGFHAMPSEIFNF 393
Cdd:cd23988   186 IHAVRgYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYHYYDDLKYRyfsnAGPHRMPLEFKTL 265

                         250
                  ....*....|...
gi 2177253387 394 LHLHSRGILRVHT 406
Cdd:cd23988   266 NVLHNRGALKLTT 278
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 200-382 1.21e-28

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 110.92  E-value: 1.21e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 200 CAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTVDVGVKTDVVTVNPSIitdrFHKLEKWRRPFYRVLQVYENAS 279
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPT-KGFEKDVGSKTTFRVLNSKW----AGFYLRGPRCGCHPLPLEEEVV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 280 VLLPAFYNTRNTDVSIRVKYvlddfqSPQAVYYFH---PQYLVNVSRYWLSLGVRAKRI----STGLILATAALELCEEV 352
Cdd:cd19952    76 LILSRAAAADFKRLKRRKKR------HDNAVLLLTdpaPDLLSYVRKRLEKLGLKSFFGgnapSSGLLAVLLALQLCDSV 149

                         170       180       190
                  ....*....|....*....|....*....|
gi 2177253387 353 HLFGFWAFPMNPSGLYitHHYYDNVKPRPG 382
Cdd:cd19952   150 DLYGFGVDSGHAPKVP--YHYYDLVEAEEG 177
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 148-406 1.43e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 91.16  E-value: 1.43e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 148 NAPSFLFTTQKNTPLGTKlkyEVDTSGIYHINQEIFRMFPKDMPYNRSQFKK---CAVVGNGGILKNSRCGREINSADFV 224
Cdd:cd23964    33 NPEEYNRLSHYKLPFGWG---GLNREVVERLLRNLNLTSSRYMFVLRGGRPRcirCAVVGNGGILNGSGKGKEIDAHDYV 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 225 FRCNLPPISEKYtVDVGVKTD--VVTVNPSIITDRFHklekwrrpfyrVLQVYENASVLLP-----------AFYNTRNT 291
Cdd:cd23964   110 FRVNHALTKGFE-KDVGTKTSfyTFFPESLHNSLLKH-----------VPQDKDTKYLFIPfkirdydyldaVLSGKPVP 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 292 DVSIRVKYVLDDFQS---PQAVYYFHPQYLVNVSRYWLslgvRAKRI---STGLILATAALELCEEVHLFGF---WAFPM 362
Cdd:cd23964   178 DGCDKGKRPPPLFGPklnATNVRLLHPDFIRYLFNRWL----NSSTSyrpTTGALMLLTALHTCDQVSVYGFgydPRFSL 253

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2177253387 363 npsglyithHYYDN----VKPRPGFHAMPSEIFNFLHLHSRGILRVHT 406
Cdd:cd23964   254 ---------HYYDKtfvkFTVFYANHDFTNERKLWRKLHEEGIINLYR 292
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 184-406 1.55e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 88.27  E-value: 1.55e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 184 RMFPKDM-PYNRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNlPPISEKYTVDVGVKTDVVTVNPSIItdrFHKLE 262
Cdd:cd23974    70 QMFDWWDrPNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVN-GAITKGFEKDVGRRTSFYTFSTNTL---MNSLR 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 263 KWRRPFYRVL-QVYENASVLLP-----------AFYNT---RNTDVSIR-VKYVLDDFqSPQAVYYFHP---QYLVNvsR 323
Cdd:cd23974   146 AYAGVGFNGPpQSKETRYIFLPdhdrdyllvkaALTHTpidRGRDKSKRpSKYFGKDV-TAEKFKIYHPdfiRYLRN--R 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 324 YWLS--LGVRAKRI---STGLILATAALELCEEVHLFGFwafpMNPSGLYITHHYYDNVKPRPGF---HAMPSEIFNFLH 395
Cdd:cd23974   223 FLWSpiLNTKQRDIyrpSTGAVMLLAALHTCDQVSAYGF----MTPDYGKYSDHYYDKTYHKVVFyanHDLRLEMQLWQK 298

                         250
                  ....*....|.
gi 2177253387 396 LHSRGILRVHT 406
Cdd:cd23974   299 LHKAGLIKLYM 309
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 180-405 6.61e-19

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 86.18  E-value: 6.61e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 180 QEIFRMFPKDMPY---NRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTVDVGVKTdvvtvnpsiiTD 256
Cdd:cd23966    57 EKLFQVVPGENPYrtrDPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPT-KGFEKDVGSKT----------TH 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 257 RFhklekwrrpfyrvlqVY-ENAS--------VLLP-----------AFYNTRNTDVSIRVKYVLDdfQSPQAVYYFHPQ 316
Cdd:cd23966   126 HF---------------MYpESAVdldpgvhlVLVPfkvldlqwlisALTTGEITRTYTPVKRFIK--ADKDKVLVINPA 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 317 YLVNVSRYWLSLgvRAKRISTGLILATAALELCEEVHLFGFWAfpmNPSGLYitHHYYDNVKPRPGFHAMPSEIFNFLH- 395
Cdd:cd23966   189 FIKYVHDNWTEH--HGRYPSTGFLALIFALHICDEVSVFGFGA---DSKGNW--HHYWEKNRSAGAFRKTGVHDADFESd 261

                         250
                  ....*....|....
gi 2177253387 396 ----LHSRGILRVH 405
Cdd:cd23966   262 iikkLAKEGKIRVY 275
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 198-395 1.11e-16

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 78.10  E-value: 1.11e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 198 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTVDVGVKTdvvtvnpsiiTDRFhklekwrrpfyrvlqVYEN 277
Cdd:cd23967     3 RRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPV-KGYEKDVGSKT----------TFRM---------------FYPE 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 278 ASVLLPAFYNtRNTDVSIrVKYVLDDFQSPQAVYY---------------------------FHPQYLVNVSRYWLSL-- 328
Cdd:cd23967    57 SAFRDPEEYD-SDWLLVL-VPFKSMDLLWLQAVIKgkkpngkggfwkkiatsvpkppkkiriLNPYILQEAAFDLIGLpm 134

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2177253387 329 --GVRAKRISTGLILATAALELCEEVHLFGFWAFPMNPSglyITHHYYDNVKprpgfhaMPSEIFNFLH 395
Cdd:cd23967   135 ngKQGKNVPTTGIIAIVMALHYCDEVDIAGFGYDPSDPN---APLHYYDSLT-------MKAIKRSWTH 193
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 197-378 2.98e-15

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 75.38  E-value: 2.98e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 197 FKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPiSEKYTVDVGVKTDVVTVNPSIITDRFHKLekWRRPFYRvlqvye 276
Cdd:cd23968    45 YNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAP-TKGFEKDVGSKTTLRLINSQILSKPEFNF--LTDPLYR------ 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 277 NASVLL--PAFYNTRNTDVSIRVKYvlDDF--------QSP-QAVYYFHPQYLVNVsryWLSLGVRAKRI------STGL 339
Cdd:cd23968   116 NVTLLVwdPSSYNVNLEKWYKKPDF--DFFpnyikyrrRHPeEPFYLIDPRFLWRL---WDILQEYTPEKikpnppSSGF 190

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2177253387 340 ILATAALELCEEVHLFGFWafpmnPSgLYITH--HYYDNVK 378
Cdd:cd23968   191 IGIVLMLHLCDWVDVYEYV-----PS-VRQTDrcHYYDVEK 225
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 165-376 6.94e-15

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 74.53  E-value: 6.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 165 KLKYEVDTSGIYHINQEIFRMFPKD---MPYNRS-QFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPiSEKYTVDV 240
Cdd:cd23980    45 RLQREKKPKNLNDTIRELFQVVPGNvdpLLEKRLvSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAP-TEGFEADV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 241 GVKTDVVTVNPSIITDRFHKLEKWRRPFyRVLQVYENASVLLPAFYNTRNTDVSIRVKYvlddfqSPQAVYYFHPQYLVN 320
Cdd:cd23980   124 GSKTTHHFVYPESFRELAQNVSMILVPF-KTLDLEWVISATTTGTISHTYVPVPRKIKV------KKEKILIYHPAFIKY 196

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2177253387 321 VSRYWLSLGVRAKriSTGLILATAALELCEEVHLFGFWAfpmNPSGLYitHHYYDN 376
Cdd:cd23980   197 VFDRWLQGHGRYP--STGILSVIFSLHVCDEVDLYGFGA---DSKGNW--HHYWEN 245
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 199-405 8.30e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 74.47  E-value: 8.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 199 KCAVVGNGGILKNSRCGREINSADFVFRCNlPPISEKYTVDVGVKTDV--VTVNpsiiTDRFHKLEKWRRPFYRVLQVYE 276
Cdd:cd23972    84 RCAVVGNGGILNGSRQGRAIDAHDYVFRLN-GAVIKGFEEDVGTKTSFygFTVN----TMKNSLISYWNLGFTRTPQGQD 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 277 NASVLLPA----FYNTRNTDVSIRVKYVLDDFQSPQAvyYF------------HPQYLvnvsRYWLSLGVRAKRI----- 335
Cdd:cd23972   159 LQYIFIPSdirdYVMLRSAILGVPVPEGLDKGDRPHK--YFgpeasakkfkllHPDFI----SYLTDRFLKSKLLnthyg 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 336 -----STGLILATAALELCEEVHLFGF-----WAFpmnpsglyiTHHYYDNVKPRPGF---HAMPSEIFNFLHLHSRGIL 402
Cdd:cd23972   233 hlympSTGALMLLTALHTCDQVSAYGFitsnyWKF---------SDHYYERKKKPLVFyanHDMLLEAALWRRLHKAGIL 303


                  ...
gi 2177253387 403 RVH 405
Cdd:cd23972   304 QLY 306
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 190-407 1.02e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 74.40  E-value: 1.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 190 MPYNRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTVDVGVKTDVVTVNPSIITDRFHKLEKwrRPFY 269
Cdd:cd23973    76 SPPGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVI-KGYEEDVGTRTSFYVHTAHSITSSLMILQK--RGFK 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 270 RVLQVYENASVLLPAF---YN-----TRNTDVSIRV-------KYVLDDFqSPQAVYYFHPQYLvnvsRYWLSLGVRAK- 333
Cdd:cd23973   153 NIPQDKDIKYILFPEGprdYQwlealLKNKTIPSGAyygrrprSYFSGDF-TEDKYLVLHPDFL----RYVKNRFLRSKt 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 334 ---------RISTGLILATAALELCEEVHLFGFwafpMNPSGLYITHHYYDNVKPRPGF---HAMPSEIFNFLHLHSRGI 401
Cdd:cd23973   228 lkgkywaiyRPTTGAFLLLTALHLCDTVSAYGF----ITEDYRKYPDHYYDKKKTKLVFyinHDFRLEKKLWKRLHDEKI 303


                  ....*.
gi 2177253387 402 LRVHTG 407
Cdd:cd23973   304 IKLYQR 309
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 198-377 3.48e-13

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 68.23  E-value: 3.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 198 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISeKYTVDVGVKTDVVTVNP-SIITDRFHklekwrrpfyrvlqVYE 276
Cdd:cd23984     3 KKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVI-GYENDVGKRTTFRLCYPeSIFSDPSH--------------YDP 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 277 NASVLLPAFyntRNTDvsirVKYVLDDFQ-------------------SPQAVYYFHPQYLVNVSRYWLSLGVR------ 331
Cdd:cd23984    68 NTTVVLIPF---KPHD----LRWLLDLLMgkkvsakgfwkkpalnliyKPNQIRILNPFILRIAAYELLHFPKRfpkekk 140

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2177253387 332 AKRISTGLILATAALELCEEVHLFGfwaFPMNPSGLYITHHYYDNV 377
Cdd:cd23984   141 PKHPTTGIIAITLALHICNEVHIAG---FKYDFSNLNSTLHYYGNE 183
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 196-357 5.26e-12

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 65.88  E-value: 5.26e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 196 QFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISeKYTVDVGVKTDVVTVNPSIITDRFHKLEKwrRPFYR--VLQ 273
Cdd:cd23985    44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTA-GFQQDVGTKTTIRLINSQLVTTEKHKFLK--DSLYNegILI 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 274 VYEnasvllPAFYNT------RNTDVSIRVKYVLDDFQSP-QAVYYFHPQY---LVNVSRYWLSLGVRAKRISTGLILAT 343
Cdd:cd23985   121 VWD------PAPYHSdipewyKNPDYNFFENYKTYRRLNPnQPFYILHPQMqweLWDIIQENSPEEIQPNPPSSGMLGII 194

                         170
                  ....*....|....
gi 2177253387 344 AALELCEEVHLFGF 357
Cdd:cd23985   195 LMMTLCDQVDVYEF 208
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 198-395 1.41e-11

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 63.53  E-value: 1.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 198 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEkYTVDVGVKTDVvtvnpsiitdrfhklekwrRPFYRvlqvyEN 277
Cdd:cd23982     3 RRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRG-FEKDVGSKTTI-------------------RLFYP-----ES 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 278 ASVlLPAFYNTRNT--------DVSIR-VKYVLDD--------FQSPQAVYYF--------HPQYLVNVSRYWLSLGVRA 332
Cdd:cd23982    58 AQF-DPGIENDPDTllvlvpfkPLDFYwLYEILSNekrvrkgfWKQPPRIWDAnpkqirilNPYYTYVAATKLLQVPGQR 136

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2177253387 333 KRI---STGLILATAALELCEEVHLFGFwAFPMNPSGlYITHHYYDNVKPRpgfhAMPSEIFNFLH 395
Cdd:cd23982   137 KKKqkpTTGLLAITLALHLCDEVHIAGF-GYPDNGNS-NQPIHYYNQITLK----SMANSGHNLNA 196
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 184-357 1.61e-11

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 64.47  E-value: 1.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 184 RMFPKdMPYNRSQ---FKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPiSEKYTVDVGVKTDVVTVNPSIITDRFHK 260
Cdd:cd23986    34 KYVPK-IPLSKLHlrgFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAP-TRGYEKDVGNKTTIRIINSQILTNPNHH 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 261 LEkwRRPFYR--VLQVYENA--SVLLPAFYNtrNTDVSIRVKYVLDDFQSP-QAVYYFHPQY---LVNVSRYWLSLGVRA 332
Cdd:cd23986   112 FI--DSSLYKdvILVAWDPApySANLHKWYK--KPDYNLFTPYVQYRKRNPnQPFYILHPKFiwqLWDIIQENTQEKIQP 187

                         170       180
                  ....*....|....*....|....*
gi 2177253387 333 KRISTGLILATAALELCEEVHLFGF 357
Cdd:cd23986   188 NPPSSGFIGILIMMSMCREVHVYEY 212
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 198-375 1.47e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 60.72  E-value: 1.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 198 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTVDVGVKTDV-----VTVnPSIITDRFHKLEKWRRPFYRVL 272
Cdd:cd23965     2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPT-RGYEKDVGRRTTIrvvshSSL-PRLLRNAILLLAGTRAPTVVVF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 273 QVYEnasvllpafyNTRNTDVSIRVKYVLD-DFQSPQAVYYFHPQYLVN-----------VSRY----WLslgvrakriS 336
Cdd:cd23965    80 WGPE----------TKMNKDGAGKYNLLRSlSKKYPDVEFYSLTPEKMDyadelfeketgKSRIksgtWL---------S 140

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2177253387 337 TGLILATAALELCEEVHLFG-----FWAFPMNPSGLYithHYYD 375
Cdd:cd23965   141 TGWFTMLLALDVCDEIKVYGmvpenYCREHPNSKVPY---HYYE 181
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 166-376 5.84e-10

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 59.89  E-value: 5.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 166 LKYEVDTSGIYHINQEIFRMFPKDMPYN---RSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPiSEKYTVDVGV 242
Cdd:cd23979    46 LQPQFKPHNTKEVLSKLFQIIPGENPYRswdPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAP-TVGFEADVGS 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 243 KTDVVTVNPSIITDRFHKLEKWRRPFyRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFQ--SPQAVYYFHPQYLVN 320
Cdd:cd23979   125 RTTHHFMYPESAKNLPANVSFVLVPF-KTLDLLWITSALSTGQIRFTYAPVKQFLRVDKDKVQiyNPAFFKYIHDRWTEH 203

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2177253387 321 VSRYwlslgvrakrISTGLILATAALELCEEVHLFGFWAfpmNPSGLYitHHYYDN 376
Cdd:cd23979   204 HGRY----------PSTGMLVLFFALHVCDEVNVYGFGA---DSRGNW--HHYWEN 244
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 198-378 3.17e-09

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 56.47  E-value: 3.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 198 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTVDVGVKTDVVTVNPSIITDRFHKLE----------KWRRP 267
Cdd:cd23981     3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPV-KGFEKDVGSKTTLRITYPEGAIQKPEQYEkdslfvlagfKWQDF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 268 FYRVLQVYENASVLLPAFYNTrntdVSIRVKyvlddfQSPQAVYYFHPQYLVNVSRYWLSLGV------RAKRISTGLIL 341
Cdd:cd23981    82 KWLKYIVYKEKVSASDGFWKS----VATRVP------REPHEIRILNPYFIQEAAFSFIGLPFnnglmgRGNIPTLGSVA 151

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2177253387 342 ATAALELCEEVHLFGFwAFPMNPSglYITHHYYDNVK 378
Cdd:cd23981   152 ITMALHNCDEVAVAGF-GYDMNTP--NAPLHYYETIK 185
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 198-377 6.56e-07

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 49.74  E-value: 6.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 198 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTVDVGVKTDVVTVNPS------IITDR-------------F 258
Cdd:cd23983     3 RRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPV-QGYSQDVGNKTTIRMTYPEgapkseQEYDPtslfvavlfksvdF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 259 HKLEK---------WRRPFYrvLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFQSPQAVYYFHPQylvNVSrywlSLG 329
Cdd:cd23983    82 AWLKAmvkkeplsfWSRLFF--WKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDK---NVP----TLG 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2177253387 330 VrakrisTGLILATaalELCEEVHLFGFwAFPMNPSGLYIthHYYDNV 377
Cdd:cd23983   153 V------TAVVLAT---HLCDEVSLAGF-GYDLSQPHAPL--HYYDSV 188
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 198-375 2.46e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 45.24  E-value: 2.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 198 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPiSEKYTVDVGVKTDVVTVN----PSIITDRFHKLEKWRRPFYRVLQ 273
Cdd:cd23977     2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAP-TAGYEADVGNRSSLRVVShtsvPLLLRNQGYFFQQSRDTKYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 274 VYENASVLLPAfyNTRNTDVSIRVKYvlddfqsPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILATA------ALE 347
Cdd:cd23977    81 PERNMDRDGGG--KTYRALLTLAKMY-------PHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGwftmilALE 151

                         170       180       190
                  ....*....|....*....|....*....|
gi 2177253387 348 LCEEVHLFGFW--AFPMNPSGLYITHHYYD 375
Cdd:cd23977   152 LCEEILVYGMVsdSYCRNKNHSSVPYHYYE 181
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 200-375 1.11e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 43.38  E-value: 1.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 200 CAVVGNGGILKNSRCGREINSADFVFRCNLPPiSEKYTVDVGVKTDVVTVN----PSIITDrfhklekwrrPFYRVLQVY 275
Cdd:cd23975     4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAP-TKGYEEDVGKRTTIRVVShtsvPLLLKN----------PDYFFKETN 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177253387 276 ENASVLLPAFYNTRNTDVSI---RVKYVLDDFqsPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILATA------AL 346
Cdd:cd23975    73 ETIYVIWGPFRNMRKDGKGIvynMLKKAVESY--PQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGwftlilAM 150

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2177253387 347 ELCEEVHLFGFWAFPMNPSGLY--ITHHYYD 375
Cdd:cd23975   151 DACYGIHVYGMINDTYCKTEGYrkVPYHYYE 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH