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Conserved domains on  [gi|2130871458|ref|XP_044936705|]
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ataxin-7-like protein 3 isoform X2 [Mustela putorius furo]

Protein Classification

Sgf11 and SCA7 domain-containing protein( domain architecture ID 10548534)

Sgf11 and SCA7 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sgf11 pfam08209
Sgf11 (transcriptional regulation protein); The Sgf11 family is a SAGA complex subunit in ...
 80-112 3.34e-16

Sgf11 (transcriptional regulation protein); The Sgf11 family is a SAGA complex subunit in Saccharomyces cerevisiae. The SAGA complex is a multisubunit protein complex involved in transcriptional regulation. SAGA combines proteins involved in interactions with DNA-bound activators and TATA-binding protein (TBP), as well as enzymes for histone acetylation and deubiquitylation.


:

Pssm-ID: 369754  Cd Length: 33  Bit Score: 71.44  E-value: 3.34e-16
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2130871458  80 KSKECVCPNCSRSIAASRFAPHLEKCLGMGRNS 112
Cdd:pfam08209   1 KSPYFTCPNCGRQIAASRFAPHLEKCLGRGRRR 33
SCA7 super family cl07068
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ...
 227-256 9.36e-04

SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.


The actual alignment was detected with superfamily member pfam08313:

Pssm-ID: 462422  Cd Length: 61  Bit Score: 37.20  E-value: 9.36e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 2130871458 227 QCGVISEhTKKMCTRSVRCPQHTDEQRRAV 256
Cdd:pfam08313  14 QCGVILP-NGGPCTRSLTCKTHSMGAKRAV 42
 
Name Accession Description Interval E-value
Sgf11 pfam08209
Sgf11 (transcriptional regulation protein); The Sgf11 family is a SAGA complex subunit in ...
 80-112 3.34e-16

Sgf11 (transcriptional regulation protein); The Sgf11 family is a SAGA complex subunit in Saccharomyces cerevisiae. The SAGA complex is a multisubunit protein complex involved in transcriptional regulation. SAGA combines proteins involved in interactions with DNA-bound activators and TATA-binding protein (TBP), as well as enzymes for histone acetylation and deubiquitylation.


Pssm-ID: 369754  Cd Length: 33  Bit Score: 71.44  E-value: 3.34e-16
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2130871458  80 KSKECVCPNCSRSIAASRFAPHLEKCLGMGRNS 112
Cdd:pfam08209   1 KSPYFTCPNCGRQIAASRFAPHLEKCLGRGRRR 33
SCA7 pfam08313
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ...
 227-256 9.36e-04

SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.


Pssm-ID: 462422  Cd Length: 61  Bit Score: 37.20  E-value: 9.36e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 2130871458 227 QCGVISEhTKKMCTRSVRCPQHTDEQRRAV 256
Cdd:pfam08313  14 QCGVILP-NGGPCTRSLTCKTHSMGAKRAV 42
 
Name Accession Description Interval E-value
Sgf11 pfam08209
Sgf11 (transcriptional regulation protein); The Sgf11 family is a SAGA complex subunit in ...
 80-112 3.34e-16

Sgf11 (transcriptional regulation protein); The Sgf11 family is a SAGA complex subunit in Saccharomyces cerevisiae. The SAGA complex is a multisubunit protein complex involved in transcriptional regulation. SAGA combines proteins involved in interactions with DNA-bound activators and TATA-binding protein (TBP), as well as enzymes for histone acetylation and deubiquitylation.


Pssm-ID: 369754  Cd Length: 33  Bit Score: 71.44  E-value: 3.34e-16
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2130871458  80 KSKECVCPNCSRSIAASRFAPHLEKCLGMGRNS 112
Cdd:pfam08209   1 KSPYFTCPNCGRQIAASRFAPHLEKCLGRGRRR 33
SCA7 pfam08313
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ...
 227-256 9.36e-04

SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.


Pssm-ID: 462422  Cd Length: 61  Bit Score: 37.20  E-value: 9.36e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 2130871458 227 QCGVISEhTKKMCTRSVRCPQHTDEQRRAV 256
Cdd:pfam08313  14 QCGVILP-NGGPCTRSLTCKTHSMGAKRAV 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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