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Conserved domains on  [gi|2129501655|ref|XP_044849817|]
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A-kinase anchor protein 10, mitochondrial isoform X5 [Mauremys mutica]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
161-544 1.91e-104

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 319.55  E-value: 1.91e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 161 RAVTRCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQI 240
Cdd:COG2319    65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 241 FLWDPDTGNQIgRVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-L 319
Cdd:COG2319   145 RLWDLATGKLL-RTLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkL 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 320 LFSSSQDRTIKVWRGQDGILCRTLQGHGHWVNTMALSTDyvlrtgafepaeasvnpqdmsgtlaelkekaqhrydqvrGQ 399
Cdd:COG2319   219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD---------------------------------------GR 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 400 gpeRLVSGSDDFTLFLWApAEDKKALERMTGHQALINQVLFSPDTRIIASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQ 479
Cdd:COG2319   260 ---LLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2129501655 480 IAWSADSRLLVSGSSDSTLKVWDAKTRKLAIDLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWR 544
Cdd:COG2319   336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 77-137 2.15e-13

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


:

Pssm-ID: 462380  Cd Length: 66  Bit Score: 64.85  E-value: 2.15e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2129501655  77 LLILFKDEAGE--ILGSPFDVPVDITPEKLQLVCNVLLQKEE---PLPLAFYVHDAEIITSLEKTL 137
Cdd:pfam08154   1 VQVRFVTKEGElaVPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
AKAP10_AKB super family cl17159
PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of ...
 1-28 1.18e-07

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.


The actual alignment was detected with superfamily member cd12804:

Pssm-ID: 214003  Cd Length: 45  Bit Score: 48.20  E-value: 1.18e-07
                          10        20
                  ....*....|....*....|....*...
gi 2129501655   1 MAWRIAKMIVNDVMQQAQNDQPLEKVTK 28
Cdd:cd12804    17 MAWKIAKMIVNDVEDQAQEEMAWQVAEM 44
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
161-544 1.91e-104

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 319.55  E-value: 1.91e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 161 RAVTRCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQI 240
Cdd:COG2319    65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 241 FLWDPDTGNQIgRVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-L 319
Cdd:COG2319   145 RLWDLATGKLL-RTLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkL 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 320 LFSSSQDRTIKVWRGQDGILCRTLQGHGHWVNTMALSTDyvlrtgafepaeasvnpqdmsgtlaelkekaqhrydqvrGQ 399
Cdd:COG2319   219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD---------------------------------------GR 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 400 gpeRLVSGSDDFTLFLWApAEDKKALERMTGHQALINQVLFSPDTRIIASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQ 479
Cdd:COG2319   260 ---LLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2129501655 480 IAWSADSRLLVSGSSDSTLKVWDAKTRKLAIDLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWR 544
Cdd:COG2319   336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 166-544 3.87e-88

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 273.44  E-value: 3.87e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 166 CTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLWDP 245
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 246 DTGNQIgRVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-LLFSSS 324
Cdd:cd00200    81 ETGECV-RTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSS 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 325 QDRTIKVWRGQDGILCRTLQGHGHWVNTMAlstdyvlrtgafepaeasvnpqdmsgtlaelkekaqhrydqvrgqgperl 404
Cdd:cd00200   155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVA-------------------------------------------------- 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 405 vsgsddftlflwapaedkkalermtghqalinqvlFSPDTRIIASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQIAWSA 484
Cdd:cd00200   185 -----------------------------------FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 485 DSRLLVSGSSDSTLKVWDAKTRKLAIDLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWR 544
Cdd:cd00200   230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 77-137 2.15e-13

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 64.85  E-value: 2.15e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2129501655  77 LLILFKDEAGE--ILGSPFDVPVDITPEKLQLVCNVLLQKEE---PLPLAFYVHDAEIITSLEKTL 137
Cdd:pfam08154   1 VQVRFVTKEGElaVPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 165-202 4.07e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.01  E-value: 4.07e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2129501655  165 RCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWD 202
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
165-202 1.02e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.89  E-value: 1.02e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2129501655 165 RCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWD 202
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 401-516 7.17e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 54.90  E-value: 7.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 401 PERLVSGSDDFTLFLWA-PAEDKKA-----LERMTGHQALINQVLFSPDTR-IIASASFDKSIKLWDGRTGKYLTSLRGH 473
Cdd:PTZ00421   88 PQKLFTASEDGTIMGWGiPEEGLTQnisdpIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCH 167

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2129501655 474 VSAVYQIAWSADSRLLVSGSSDSTLKVWDAKTRKLAIDLPGHA 516
Cdd:PTZ00421  168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
AKAP10_AKB cd12804
PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of ...
 1-28 1.18e-07

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.


Pssm-ID: 214003  Cd Length: 45  Bit Score: 48.20  E-value: 1.18e-07
                          10        20
                  ....*....|....*....|....*...
gi 2129501655   1 MAWRIAKMIVNDVMQQAQNDQPLEKVTK 28
Cdd:cd12804    17 MAWKIAKMIVNDVEDQAQEEMAWQVAEM 44
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
161-544 1.91e-104

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 319.55  E-value: 1.91e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 161 RAVTRCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQI 240
Cdd:COG2319    65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 241 FLWDPDTGNQIgRVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-L 319
Cdd:COG2319   145 RLWDLATGKLL-RTLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkL 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 320 LFSSSQDRTIKVWRGQDGILCRTLQGHGHWVNTMALSTDyvlrtgafepaeasvnpqdmsgtlaelkekaqhrydqvrGQ 399
Cdd:COG2319   219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD---------------------------------------GR 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 400 gpeRLVSGSDDFTLFLWApAEDKKALERMTGHQALINQVLFSPDTRIIASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQ 479
Cdd:COG2319   260 ---LLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2129501655 480 IAWSADSRLLVSGSSDSTLKVWDAKTRKLAIDLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWR 544
Cdd:COG2319   336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
164-505 2.63e-91

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 285.65  E-value: 2.63e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 164 TRCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLW 243
Cdd:COG2319   110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 244 DPDTGNQIgRVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-LLFS 322
Cdd:COG2319   190 DLATGKLL-RTLTGHTGAVRSVAF-----SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLAS 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 323 SSQDRTIKVWRGQDGILCRTLQGHGHWVNTMALSTDyvlrtgafepaeasvnpqdmsgtlaelkekaqhrydqvrGQgpe 402
Cdd:COG2319   264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD---------------------------------------GK--- 301

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 403 RLVSGSDDFTLFLWApAEDKKALERMTGHQALINQVLFSPDTRIIASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQIAW 482
Cdd:COG2319   302 LLASGSDDGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380

                         330       340
                  ....*....|....*....|...
gi 2129501655 483 SADSRLLVSGSSDSTLKVWDAKT 505
Cdd:COG2319   381 SPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
161-545 3.56e-89

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 280.26  E-value: 3.56e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 161 RAVTRCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQI 240
Cdd:COG2319    23 AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 241 FLWDPDTGnQIGRVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-L 319
Cdd:COG2319   103 RLWDLATG-LLLRTLTGHTGAVRSVAF-----SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGkL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 320 LFSSSQDRTIKVWRGQDGILCRTLQGHGHWVNTMALSTDyvlrtgafepaeasvnpqdmsgtlaelkekaqhrydqvrGQ 399
Cdd:COG2319   177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD---------------------------------------GK 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 400 gpeRLVSGSDDFTLFLWaPAEDKKALERMTGHQALINQVLFSPDTRIIASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQ 479
Cdd:COG2319   218 ---LLASGSADGTVRLW-DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNS 293

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2129501655 480 IAWSADSRLLVSGSSDSTLKVWDAKTRKLAIDLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWRR 545
Cdd:COG2319   294 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 166-544 3.87e-88

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 273.44  E-value: 3.87e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 166 CTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLWDP 245
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 246 DTGNQIgRVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-LLFSSS 324
Cdd:cd00200    81 ETGECV-RTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSS 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 325 QDRTIKVWRGQDGILCRTLQGHGHWVNTMAlstdyvlrtgafepaeasvnpqdmsgtlaelkekaqhrydqvrgqgperl 404
Cdd:cd00200   155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVA-------------------------------------------------- 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 405 vsgsddftlflwapaedkkalermtghqalinqvlFSPDTRIIASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQIAWSA 484
Cdd:cd00200   185 -----------------------------------FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 485 DSRLLVSGSSDSTLKVWDAKTRKLAIDLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWR 544
Cdd:cd00200   230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
181-543 9.70e-74

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 239.81  E-value: 9.70e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 181 AFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLWDPDTGnQIGRVLAGHSK 260
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-ALLATLLGHTA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 261 WITwlcwePLHINPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-LLFSSSQDRTIKVWRGQDGIL 339
Cdd:COG2319    80 AVL-----SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGkTLASGSADGTVRLWDLATGKL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 340 CRTLQGHGHWVNTMALSTDyvlrtgafepaeasvnpqdmsgtlaelkekaqhrydqvrGQgpeRLVSGSDDFTLFLWApA 419
Cdd:COG2319   155 LRTLTGHSGAVTSVAFSPD---------------------------------------GK---LLASGSDDGTVRLWD-L 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 420 EDKKALERMTGHQALINQVLFSPDTRIIASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQIAWSADSRLLVSGSSDSTLK 499
Cdd:COG2319   192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 2129501655 500 VWDAKTRKLAIDLPGHADEVFAVDWSPDGQRVASGGKDKCLRIW 543
Cdd:COG2319   272 LWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 165-359 6.91e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 189.47  E-value: 6.91e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 165 RCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLWD 244
Cdd:cd00200    84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 245 PDTGnQIGRVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-LLFSS 323
Cdd:cd00200   164 LRTG-KCVATLTGHTGEVNSVAF-----SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGyLLASG 237

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2129501655 324 SQDRTIKVWRGQDGILCRTLQGHGHWVNTMALSTDY 359
Cdd:cd00200   238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDG 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 165-333 8.67e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 180.99  E-value: 8.67e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 165 RCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLWD 244
Cdd:cd00200   126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 245 PDTGNQIGrVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-LLFSS 323
Cdd:cd00200   206 LSTGKCLG-TLRGHENGVNSVAF-----SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASG 279

                         170
                  ....*....|
gi 2129501655 324 SQDRTIKVWR 333
Cdd:cd00200   280 SADGTIRIWD 289
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 77-137 2.15e-13

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 64.85  E-value: 2.15e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2129501655  77 LLILFKDEAGE--ILGSPFDVPVDITPEKLQLVCNVLLQKEE---PLPLAFYVHDAEIITSLEKTL 137
Cdd:pfam08154   1 VQVRFVTKEGElaVPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
WD40 COG2319
WD40 repeat [General function prediction only];
439-544 1.52e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.01  E-value: 1.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 439 LFSPDTRIIASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQIAWSADSRLLVSGSSDSTLKVWDAKTRKLAIDLPGHADE 518
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100
                  ....*....|....*....|....*.
gi 2129501655 519 VFAVDWSPDGQRVASGGKDKCLRIWR 544
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWD 106
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 165-202 4.07e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.01  E-value: 4.07e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2129501655  165 RCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWD 202
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 463-502 8.31e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.24  E-value: 8.31e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2129501655  463 TGKYLTSLRGHVSAVYQIAWSADSRLLVSGSSDSTLKVWD 502
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
165-202 1.02e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.89  E-value: 1.02e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2129501655 165 RCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWD 202
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
464-502 8.40e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.19  E-value: 8.40e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2129501655 464 GKYLTSLRGHVSAVYQIAWSADSRLLVSGSSDSTLKVWD 502
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 205-244 2.27e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 2.27e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2129501655  205 TETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLWD 244
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 505-543 6.54e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 6.54e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2129501655  505 TRKLAIDLPGHADEVFAVDWSPDGQRVASGGKDKCLRIW 543
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 401-516 7.17e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 54.90  E-value: 7.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 401 PERLVSGSDDFTLFLWA-PAEDKKA-----LERMTGHQALINQVLFSPDTR-IIASASFDKSIKLWDGRTGKYLTSLRGH 473
Cdd:PTZ00421   88 PQKLFTASEDGTIMGWGiPEEGLTQnisdpIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCH 167

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2129501655 474 VSAVYQIAWSADSRLLVSGSSDSTLKVWDAKTRKLAIDLPGHA 516
Cdd:PTZ00421  168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
AKAP10_AKB cd12804
PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of ...
 1-28 1.18e-07

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.


Pssm-ID: 214003  Cd Length: 45  Bit Score: 48.20  E-value: 1.18e-07
                          10        20
                  ....*....|....*....|....*...
gi 2129501655   1 MAWRIAKMIVNDVMQQAQNDQPLEKVTK 28
Cdd:cd12804    17 MAWKIAKMIVNDVEDQAQEEMAWQVAEM 44
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 295-332 1.53e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.53e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2129501655  295 TGRCDKILTGHTQSVTCVKWGGDG-LLFSSSQDRTIKVW 332
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 156-332 4.83e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.20  E-value: 4.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 156 AVFKVRAVTRCTSS---LEGHTEAVISVAFSP-TGKYLASGSGDTTVRFWDLSTE-------TPHFTAKGHRHWVLSIAW 224
Cdd:PTZ00421   54 AVLKHTDYGKLASNppiLLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEgltqnisDPIVHLQGHTKKVGIVSF 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 225 SPNGRK-LASGCKNSQIFLWDPDTGnQIGRVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILT 303
Cdd:PTZ00421  134 HPSAMNvLASAGADMVVNVWDVERG-KAVEVIKCHSDQITSLEW-----NLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE 207

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2129501655 304 GH--TQSVTCVkWGGDGLL-----FSSSQDRTIKVW 332
Cdd:PTZ00421  208 AHasAKSQRCL-WAKRKDLiitlgCSKSQQRQIMLW 242
WD40 pfam00400
WD domain, G-beta repeat;
512-543 5.40e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 5.40e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2129501655 512 LPGHADEVFAVDWSPDGQRVASGGKDKCLRIW 543
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 421-460 5.99e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 5.99e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2129501655  421 DKKALERMTGHQALINQVLFSPDTRIIASASFDKSIKLWD 460
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 382-502 6.56e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.40  E-value: 6.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 382 LAELKEKAQHRYD-QVRGQGPERLVSGSDDFTLFLWAPAEDKKALERMTghQALINQVLFSPDT-RIIASASFDKSIKLW 459
Cdd:PLN00181  568 VTEMKEHEKRVWSiDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT--KANICCVQFPSESgRSLAFGSADHKVYYY 645

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2129501655 460 DGRTGKY-LTSLRGHVSAVYQIAWsADSRLLVSGSSDSTLKVWD 502
Cdd:PLN00181  646 DLRNPKLpLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWD 688
WD40 pfam00400
WD domain, G-beta repeat;
296-332 6.83e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 6.83e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2129501655 296 GRCDKILTGHTQSVTCVKWGGDG-LLFSSSQDRTIKVW 332
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 253-292 8.86e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 8.86e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2129501655  253 RVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWD 292
Cdd:smart00320   6 KTLKGHTGPVTSVAF-----SPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
422-460 1.37e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.37e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2129501655 422 KKALERMTGHQALINQVLFSPDTRIIASASFDKSIKLWD 460
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 189-365 1.50e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 1.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 189 LASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSP-NGRKLASGCKNSQIFLWDPDTGNQIGRVlaghsKWITWLCW 267
Cdd:PLN00181  548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTI-----KTKANICC 622

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 268 EPLHiNPECRYLASASKDCSIRIWDTvtgRCDKI----LTGHTQSVTCVKWGGDGLLFSSSQDRTIKVW------RGQDG 337
Cdd:PLN00181  623 VQFP-SESGRSLAFGSADHKVYYYDL---RNPKLplctMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsiSGINE 698

                         170       180
                  ....*....|....*....|....*....
gi 2129501655 338 ILCRTLQGHGHWVNTMALS-TDYVLRTGA 365
Cdd:PLN00181  699 TPLHSFMGHTNVKNFVGLSvSDGYIATGS 727
PTZ00421 PTZ00421
coronin; Provisional
 219-346 1.97e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 50.28  E-value: 1.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 219 VLSIAWSP-NGRKLASGCKNSQIFLWD-PDTGNQIGRV-----LAGHSKWITWLCWEPLHINpecrYLASASKDCSIRIW 291
Cdd:PTZ00421   78 IIDVAFNPfDPQKLFTASEDGTIMGWGiPEEGLTQNISdpivhLQGHTKKVGIVSFHPSAMN----VLASAGADMVVNVW 153

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2129501655 292 DTVTGRCDKILTGHTQSVTCVKWGGDGLLF-SSSQDRTIKVWRGQDGILCRTLQGH 346
Cdd:PTZ00421  154 DVERGKAVEVIKCHSDQITSLEWNLDGSLLcTTSKDKKLNIIDPRDGTIVSSVEAH 209
PTZ00421 PTZ00421
coronin; Provisional
 430-542 2.14e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 50.28  E-value: 2.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 430 GHQALINQVLFSP-DTRIIASASFDKSIKLWD-------GRTGKYLTSLRGHVSAVYQIAWSADSR-LLVSGSSDSTLKV 500
Cdd:PTZ00421   73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNV 152

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2129501655 501 WDAKTRKLAIDLPGHADEVFAVDWSPDGQRVASGGKDKCLRI 542
Cdd:PTZ00421  153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 pfam00400
WD domain, G-beta repeat;
207-244 2.57e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 2.57e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2129501655 207 TPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLWD 244
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
253-292 6.85e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 6.85e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2129501655 253 RVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWD 292
Cdd:pfam00400   5 KTLEGHTGSVTSLAF-----SPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 170-244 9.10e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.41  E-value: 9.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 170 LEGHTEAVISVAFSPT-GKYLASGSGDTTVRFWDLSTE--------TPHFTAKGHRHWVLSIAWSP-NGRKLASGCKNSQ 239
Cdd:PTZ00420   70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNdesvkeikDPQCILKGHKKKISIIDWNPmNYYIMCSSGFDSF 149


                  ....*
gi 2129501655 240 IFLWD 244
Cdd:PTZ00420  150 VNIWD 154
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 447-501 1.52e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 1.52e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2129501655 447 IASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQIAW-SADSRLLVSGSSDSTLKVW 501
Cdd:PLN00181  548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLW 603
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 438-532 3.21e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 46.96  E-value: 3.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655  438 VLFSPDTRIIASASfDKS--IKLW-----DGRTGKYLTSlrGHVSAVYQIAWSADSRLLVSGSSDSTLKVWDAKTRKLA- 509
Cdd:COG4946    348 PAWSPDGKSIAYFS-DASgeYELYiapadGSGEPKQLTL--GDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLASGKVRk 424

                           90       100
                   ....*....|....*....|...
gi 2129501655  510 IDLPGHADEVFAVDWSPDGQRVA 532
Cdd:COG4946    425 VDTDGYGDGISDLAWSPDSKWLA 447
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 434-543 7.83e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 7.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 434 LINQVLFSPDTRIIASASFDKSIKLW-------DGRTGKYLTSLRGHVSAVYQIAWSADSRLLVSGSS-DSTLKVWDAKT 505
Cdd:PLN00181  485 LVCAIGFDRDGEFFATAGVNKKIKIFecesiikDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNfEGVVQVWDVAR 564

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2129501655 506 RKLAIDLPGHADEVFAVDW-SPDGQRVASGGKDKCLRIW 543
Cdd:PLN00181  565 SQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLW 603
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
398-535 1.30e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.53  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 398 GQGPERLVSGSDDFTLFLWAPAEDKKALERMTGHQALINQVLFSPD-TRIIASASFDKSIKLWDGRTGKYLTSLRGHVSA 476
Cdd:COG3391    33 GGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADgRRLYVANSGSGRVSVIDLATGKVVATIPVGGGP 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2129501655 477 vYQIAWSAD-SRLLVSGSSDSTLKVWDAKTRKLAIDLPGhADEVFAVDWSPDGQR--VASGG 535
Cdd:COG3391   113 -RGLAVDPDgGRLYVADSGNGRVSVIDTATGKVVATIPV-GAGPHGIAVDPDGKRlyVANSG 172
PTZ00421 PTZ00421
coronin; Provisional
 170-293 1.34e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 170 LEGHTEAVISVAFSPTGK-YLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLWDPDTG 248
Cdd:PTZ00421  121 LQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2129501655 249 NQIGRVLA---GHSKWITWLCWEPLHINPECrylaSASKDCSIRIWDT 293
Cdd:PTZ00421  201 TIVSSVEAhasAKSQRCLWAKRKDLIITLGC----SKSQQRQIMLWDT 244
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 421-532 4.09e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 41.20  E-value: 4.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 421 DKKALERMTGHQALINQVLFSPD-TRIIASASFDKSIKLW----DGRTGKYLTSLRGHVSAvyqIAWSADSRLLV-SGSS 494
Cdd:COG0823    19 DGGEPRRLTNSPGIDTSPAWSPDgRRIAFTSDRGGGPQIYvvdaDGGEPRRLTFGGGYNAS---PSWSPDGKRLAfVSRS 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2129501655 495 DSTLKVW--DAKTRKLAIdlpgHADEVFAVDWSPDGQRVA 532
Cdd:COG0823    96 DGRFDIYvlDLDGGAPRR----LTDGPGSPSWSPDGRRIV 131
PTZ00420 PTZ00420
coronin; Provisional
 118-245 1.00e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 118 LPLAFYVHDAEIITSLEKTLvgqvveTERVLDIIYQPQAVFKVRAvTRCTssLEGHTEAVISVAFSPTGKYLASGSG-DT 196
Cdd:PTZ00420   78 LDLQFNPCFSEILASGSEDL------TIRVWEIPHNDESVKEIKD-PQCI--LKGHKKKISIIDWNPMNYYIMCSSGfDS 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2129501655 197 TVRFWDLSTETPHFTAKGHRHwVLSIAWSPNGRKLASGCKNSQIFLWDP 245
Cdd:PTZ00420  149 FVNIWDIENEKRAFQINMPKK-LSSLKWNIKGNLLSGTCVGKHMHIIDP 196
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 188-333 1.02e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 40.04  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 188 YLASGSGDTTVRFWDLSTETPH-FTAkgHRHWVLSIAWSPNGRKLA-----SGckNSQIFLWDPDTGNQIgRVLAGHSKw 261
Cdd:COG0823     3 FTLSRDGNSDIYVVDLDGGEPRrLTN--SPGIDTSPAWSPDGRRIAftsdrGG--GPQIYVVDADGGEPR-RLTFGGGY- 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2129501655 262 itwlCWEPlHINPECRYLASASKD---CSIRIWDTVTGRcDKILTGHTQSVTcvkWGGDG--LLFSSSQDRTIKVWR 333
Cdd:COG0823    77 ----NASP-SWSPDGKRLAFVSRSdgrFDIYVLDLDGGA-PRRLTDGPGSPS---WSPDGrrIVFSSDRGGRPDLYV 144
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 176-326 2.73e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 40.79  E-value: 2.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655  176 AVISVAFSPTGKYLA-----SGSgdttvrfWDL------STETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLWD 244
Cdd:COG4946    344 RERLPAWSPDGKSIAyfsdaSGE-------YELyiapadGSGEPKQLTLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVD 416

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655  245 PDTGN--QIGRVLAGH----------SKWITWLCWEPLHINpecrylasaskdcSIRIWDTVTGrcdKI--LTGHTQSVT 310
Cdd:COG4946    417 LASGKvrKVDTDGYGDgisdlawspdSKWLAYSKPGPNQLS-------------QIFLYDVETG---KTvqLTDGRYDDG 480

                          170
                   ....*....|....*...
gi 2129501655  311 CVKWGGDG--LLFSSSQD 326
Cdd:COG4946    481 SPAFSPDGkyLYFLSSRD 498
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 167-227 3.17e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 3.17e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2129501655 167 TSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPN 227
Cdd:pfam12894  31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 438-525 3.67e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 3.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 438 VLFSPDTRIIASASFDKSI--------KLWDGrtgkyltSLRGHVSAVYQIAWSADSRLLVSGSSDSTLKVWDAKTRKLA 509
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELllhrlnwqRVWTL-------SPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73

                          90
                  ....*....|....*.
gi 2129501655 510 IDLPGHADEVFAVDWS 525
Cdd:pfam12894  74 HHFSAGSDLITCLGWG 89
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 219-267 4.29e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.49  E-value: 4.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2129501655 219 VLSIAWSPNGRKLASGCKNSQIFLWDPDTGNQIgRVLAGHSKWITWLCW 267
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV-HHFSAGSDLITCLGW 88
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 451-537 7.23e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.90  E-value: 7.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501655 451 SFdKSIKLWDGRTgkyLTSLRGHVSAVYQIAWSADSRLLVSGSSDSTLKVWDA--------KTRKLAIDLP--------- 513
Cdd:pfam20426 105 SF-QVISLNDGRM---VQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVlrgrssekRSRNTQTEFPrkdhviaet 180

                          90       100       110
                  ....*....|....*....|....*....|
gi 2129501655 514 ------GHADEVFAVDWSPDGQRVASGGKD 537
Cdd:pfam20426 181 pfhilcGHDDIITCLYVSVELDIVISGSKD 210
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 181-249 8.70e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 37.34  E-value: 8.70e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2129501655 181 AFSPTGKYLA---SGSGDTTVRFWDLSTETPH-FTAKGHRHWvlSIAWSPNGRKLA-----SGckNSQIFLWDPDTGN 249
Cdd:COG0823    37 AWSPDGRRIAftsDRGGGPQIYVVDADGGEPRrLTFGGGYNA--SPSWSPDGKRLAfvsrsDG--RFDIYVLDLDGGA 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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